RETRACTED: Assessment of anticancer activity: A comparison of dose–response effect of ethyl acetate and methanolic extracts of Pergularia daemia (Forsk)

Abstract

a b s t r a c tBackground: Oral cancer is the sixth most common malignancy worldwide and is thus an important cause of death and morbidity. Although several drugs have been developed for the treatment of oral cancer, naturally occurring phytochemicals have been recommended by nutritionists and health experts to treat various types of cancer. Pergularia daemia is a well-known herb distributed across India, finding many uses in medicine. Aim: The present study was mainly designed to determine the dose-response effect of the whole plant extract of P. daemia on experimental oral carcinogenesis. Materials and methods: Male golden Syrian hamsters were painted with 0.5% of 7,12dimethylbenz[a]anthracene (DMBA) in liquid paraffin on the left buccal pouch to induce oral cancer, thrice a week for 14 weeks. The anticancer effect of the ethyl acetate and methanolic extracts of P. daemia was observed to be dose dependent (100, 200, and 300 mg/kg body weight (bwt)) by assessing the bwt, tumor incidence, changes in oxidant/antioxidant levels, and histological alterations of control and experimental animals. Results: Our results showed that of the three doses used, the high dose (300 mg/kg bwt) exhibited excellent antioxidant activity in comparison to the other two doses. Moreover, our findings suggest that the methanolic extract significantly inhibited cancer development to a greater extent than the ethyl acetate extract. Conclusion: Thus, it could be concluded that the whole plant of P. daemia presents an easily accessible source of natural antioxidants, and regular consumption can reduce the incidence of oral cancer.

Novel Strategy for Gallium-Substituted Hydroxyapatite/Pergularia daemia Fiber Extract/Poly(N-vinylcarbazole) Biocomposite Coating on Titanium for Biomedical Applications

“…The illustrative broad and intense peaks (Figure 2d) are observed at 2θ values of 25.66, 31.7, 38.94, 46.26, 49.22, and 53.4°, which strongly designates the formation of nGa-HAp/PDFE composite. 34,35 In the XRD patterns for the nGa-HAp/PDFE/PVK composite sample (Figure 2e), a broad peak and amorphous nature of nGa-HAp/PDFE/PVK composite exist along with the diffraction peaks for PVK, which clearly shows that the nGa-HAp/PDFE/PVK composite had a more ordered arrangement than the single compound due to the presence of Ga-HAp. Moreover, strong diffraction peaks were located at a 2θ value of 21.76°, which revealed face-to-face ordered structure of PVK present in the nGa-HAp/PDFE/PVK composite.…”

“…Hence, different plants have been studied using recent scientific approaches to classify various biological compounds of these medicinal plants. 34,35 Pergularia daemia (forsk, family Asclepiadaceae) is native to Asia, and it grows in plains of hotter regions of India, which is commonly known as "Veliparuthi" in Tamil Nadu. The excellent antidiabetic, hepatoprotective, anti-inflammatory, and cardiovascular effects of this natural medicinal plant have been reported in Ayurvedic and folk medicine.…”

“…Generally, plants and plant extracts have long been used in medical applications mainly due to the presence of bioactive polyphenolic compounds, which may be stored in plant parts such as leaves, roots, fruits, and seeds. Hence, different plants have been studied using recent scientific approaches to classify various biological compounds of these medicinal plants. , Pergularia daemia (forsk, family Asclepiadaceae ) is native to Asia, and it grows in plains of hotter regions of India, which is commonly known as “Veliparuthi” in Tamil Nadu. The excellent antidiabetic, hepatoprotective, anti-inflammatory, and cardiovascular effects of this natural medicinal plant have been reported in Ayurvedic and folk medicine. , Since there is no individual bioactive material available to fulfill all of the essential requirements for biomedical applications, fabrication of composite as an attractive for human bone issues has become mandatory.…”

Synthesis, In vitro, and In silico Studies of Methyl Eugenol Derivatives for Plasmodium falciparum Inhibitor

“…34 The suggested mechanism is the modulation of lipid peroxidation and enhancement of antioxidant status. The water extract (5PL), showed higher cytotoxic activity on both the HEPG2 and HCT-116 cancer cell lines represented by the lower IC50 values; 2.14 µg/ml and 2.61µg/mL, respectively, followed by the butanol extract (3PL) on both the HEPG2 and HCT-116 cancer cell lines represented by lower IC50 values; 2.52µg/mL and 3.98 µg/mL, respectively 35 . Ibrahim et al (2018), 29 proved that vitexins are lignan compounds that induce apoptosis and suppress tumor growth.…”

The Anticancer Activity of Cetraria Islandica (L.) Ach in Breast Cancer Cells Through Crosstalk of Ampk-α1 and Erk1/2 Signalling

“…Although emerging treatment strategies are promising, many of the current methods are not efficient and developing novel therapeutic approaches are a high priority. So far, an enormous number of studies were conducted to identify novel, useful phototherapeutic agents including compounds derived from plants (Bontempo et al, 2015;Shweta, et al, 2013;Unnati Shah, 2013;Vaithiyanathan and Mirunalini, 2016), fungi (Shweta et al, 2013) and lichens (Kosanic, et al, 2013). It has suggested that lichens and their secondary metabolites can be used as an alternative method for the treatment of cancers (Kosanic et al, 2013(Kosanic et al, , 2014 due to its immune stimulation effect (Colak, et al, 2013).…”