RETRACTED: Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats

He, Hui; Shi, Mengqiong; Zeng, Xiaowei; Yang, Jun Mo; Li, Yikui; Wu, Lidong; Lian-da, LI

doi:10.1016/j.jep.2008.03.006

Cited by 26 publications

(18 citation statements)

References 38 publications

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“…It has a molecular formula of C 36 H 30 O 16 and a molecular weight of 718 (Watzke et al, 2006). Sal B has multiple pharmacological activities such as antioxidative (Soung et al, 2003;Tian et al, 2008), antifibrogenic (Lin et al, 2006), myocardial salvage, and cardioprotective effects (Chen et al, 2000;Cao et al, 2003;He et al, 2008). Extensive pharmacological studies have predicted that Sal B will reverse liver fibrosis (Hase et al, 1997;Liu et al, 2002a).…”

Section: Introductionmentioning

confidence: 99%

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Pan¹,

Xie

Chen

et al. 2011

Arch. Pharm. Res.

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Salvianolic acid B (Sal B) is the most abundant bioactive molecule from Radix Salviae Miltiorrhizae, and has recently been used for treating renal fibrosis in traditional Chinese medicine. Here we investigated the ability reversal of Sal B to reverse the transdifferentiation of human kidney proximal tubular epithelial cells that was induced by transforming growth factor-beta 1 (TGF-β1). The effects of Sal B on HK-2 cell morphology were observed by phase contrast microscopy, while alpha smooth muscle actin and E-cadherin were studied by immunocytochemistry and real-time reverse transcription polymerase chain reaction, respectively. Exposure of HK-2 cells to TGF-β1 for 72 h induced a complete conversion of the epithelial cells to myofibroblasts. When HK-2 cells were co-incubated with Sal B and TGF-β1 for a further 72 h, the morphology of myofibroblasts returned to that of proximal tubular epithelial cells, whereas the myofibroblast phenotype was maintained after exposure of cells to TGF-β1 for 144 h. Sal B reduced alpha smooth muscle actin levels and increased E-cadherin levels compared with their epithelial-to-mesenchymal transition controls. The reversal effect of Sal B was dose-dependent. That Sal B reverses the epithelial-to-mesenchymal transition in vitro suggests that it could possibly facilitate the repair of tubular epithelial structures and the regression of renal fibrosis in injured kidneys.

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Section: Introductionmentioning

confidence: 99%

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Pan¹,

Xie

Chen

et al. 2011

Arch. Pharm. Res.

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“…Moreover, future research will be include more profound molecular analysis not only on calcium transient but also on the cardiac redox state [54] in hearts of animals feed pequi oil. It also would be necessary to evaluate if cardioprotective effects of pequi oil happens to be in other situations, such as, in different doses of pequi oil that mimic human servings and, or, in pathological conditions (non-alcoholic fatty liver disease, obesity, insulin resistance), or at minimal cardiometabolic disturbances, since food bioactive compounds may not show clear effects in healthy conditions.…”

Section: Discussionmentioning

confidence: 99%

Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats

Oliveira¹,

Moreno

Melo

et al. 2017

Lipids Health Dis

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Background Caryocar brasiliense (pequi) oil is high in monounsaturated fat acids (MUFA), especially oleic, and in carotenoids, which have been associated with protection against cardiovascular disease. However, this food is poorly studied in this context, especially in the cardiac function. Therefore, we investigated the effects of a long-term intake of pequi oil in systemic cardiovascular risk factors and in the ex vivo cardiac function of rats.MethodsPreviously, we determined fatty acids and carotenoids in pequi oil. Next, male rats were divided in C – control group feed a standard diet, and PO – pequi oil group fed the same diet added pequi oil (+2.25 g.100 g−1). After 15 weeks, plasma lipids, glucose, insulin, blood pressure, heart rate, hepatic lipids were accessed and visceral fat pads were harvested. Hearts were used for the ex vivo cardiac function, histologic assays, SERCA2a and phospholanban (PLB) determinations.ResultsIn agreement with scientific data, pequi oil had expressive amounts MUFA, especially oleic acid, and carotenoids. Hepatic triglycerides (TG) were reduced by pequi oil intake (p < 0.05). All others cardiovascular risk factors were not changed. The intrinsic heart rate was lower in PO group (p < 0.05). SERCA2a content was higher in this group (p < 0.05), without affecting PLB. Also, SERCA2a/PLB ratio increased in PO group (p < 0.05).Conclusion Pequi oil intake improved cardiac function ex vivo, despite no significant changes in systemic cardiovascular risk factors. The higher lipid offer in pequi oil diet, its composition in oleic acid and carotenoids could be related to those effects.

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“…Sal B is the most abundant and bioactive component from Radix Salviae miltiorrhizae, which has been considered to have multiple pharmacological activities in vivo and vitro (Cao et al, 2003;He et al, 2008;Lin et al, 2006;Tian et al, 2008). But there is insufficient information on its protective properties in cellular model of DPN.…”

Section: Discussionmentioning

confidence: 99%

Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

Sun

Xue

et al. 2012

Life Sciences

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RETRACTED: Cardioprotective effect of salvianolic acid B on large myocardial infarction mediated by reversing upregulation of leptin, endothelin pathways, and abnormal expression of SERCA2a, phospholamban in rats

Cited by 26 publications

References 38 publications

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Salvianolic acid B reverses the epithelial-to-mesenchymal transition of HK-2 cells that is induced by transforming growth factor-β

Caryocar brasiliense oil improves cardiac function by increasing Serca2a/PLB ratio despite no significant changes in cardiovascular risk factors in rats

Inhibitory effects of Salvianolic acid B on apoptosis of Schwann cells and its mechanism induced by intermittent high glucose

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