RETRACTED: Cardiorespiratory responses to hypertonic saline solution in cardiac operations

Boldt, Joachim; Zickmann, B.; Ballesteros, M.; Herold, C.; Dapper, F.; Hempelmann, G.

doi:10.1016/0003-4975(91)90320-p

Cited by 53 publications

(35 citation statements)

References 18 publications

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“…HTS has been previously studied in the setting of cardiac surgery 18,19 and has been demonstrated to improve cardiac index without a concomitant rise in pulmonary capillary wedge pressure when administered early postoperatively. 19 HTS infusion before prolonged ischemia and reperfusion protects against myocardial stunning.…”

Section: Enhanced Allograft Functional Recoverymentioning

confidence: 99%

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Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

et al. 2009

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Background-Hypertonic saline (HTS) has been previously demonstrated to have immune modulatory and vascular protective effects. We assessed the effect of donor pretreatment with HTS on allograft preservation in a porcine model of orthotopic heart transplantation. Methods and Results-Orthotopic transplants were performed after 6 hours of cold static allograft storage. Donor pigs were randomly assigned to pretreatment with (nϭ7) or without (nϭ6) HTS (4.5 mL/kg of 7.5% NaCl) administered 1 hour before donor heart arrest. Administration of HTS increased serum sodium level from 138Ϯ2 mmol/L to 154Ϯ4 mmol/L, which normalized to 144Ϯ3 mmol/L 1 hour after infusion. Successful weaning from cardiopulmonary bypass was significantly greater in HTS-treated hearts (6/7 vs 1/6; Pϭ0.029).

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Section: Enhanced Allograft Functional Recoverymentioning

confidence: 99%

“…18,19 Currently, there is some concern particularly about the presence of hypernatremia in liver organ donors as previous studies have associated organ donor hypernatremia with poor liver graft outcomes. 26,27 Our pilot study was not designed to assess the outcomes after transplantation of other organs.…”

Section: Limitationsmentioning

confidence: 99%

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

et al. 2009

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“…[92][93][94][95] There is however one study in patients with myo-cardial dysfunction undergoing coronary artery bypass in which pre-operative volume expansion with 250 mL of HSS caused hypotension and transient left ventricular failure. 103 This study showed that 7.5% NaCl solutions can be deleterious if rapidly infused in patients with ventricular dysfunction.…”

Section: Safety and Controversiesmentioning

confidence: 99%

Small Volume Hypertonic Resuscitation of Circulatory Shock

Rocha-e-Silva

Figueiredo

2005

Clinics

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Small volume hypertonic resuscitation is a relatively new conceptual approach to shock therapy. It was originally based on the idea that a relatively large blood volume expansion could be obtained by administering a relatively small volume of fluid, taking advantage of osmosis. It was soon realized that the physiological vasodilator property of hypertonicity was a useful byproduct of small volume resuscitation in that it induced reperfusion of previously ischemic territories, even though such an effect encroached upon the malefic effects of the ischemia-reperfusion process. Subsequent research disclosed a number of previously unsuspected properties of hypertonic resuscitation, amongst them the correction of endothelial and red cell edema with significant consequences in terms of capillary blood flow. A whole set of actions of hypertonicity upon the immune system are being gradually uncovered, but the full implication of these observations with regard to the clinical scenario are still under study. Small volume resuscitation for shock is in current clinical use in some parts of the world, in spite of objections raised concerning its safety under conditions of uncontrolled bleeding. These objections stem mainly from experimental studies, but there are few signs that they may be of real clinical significance. This review attempts to cover the earlier and the more recent developments in this field.

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“…2 Studies have shown that hypertonic solutions whether combined with colloids such as dextran or 6% hydroxyethyl starch or not promote a negative water balance, improved cardiac output, decreased systemic vascular resistance and reduce the need for blood products. [3][4][5][6][7][8][9] These benefits have also been shown for volume replacement with hypertonic solutions during the postoperative period following off-pump coronary artery bypass grafting. 10 Off-pump coronary artery bypass grafting reduces blood losses, myocardial infarction, acute renal failure, mediastinitis, stroke and prolonged orotracheal intubation particularly in subgroups of higher-risk patients.…”

Section: ' Introductionmentioning

confidence: 93%

Safety and efficacy of hypertonic saline versus isotonic saline solution in off-pump coronary artery bypass grafting

et al. 2014

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OBJECTIVES: Off-pump coronary artery bypass grafting occurrence increases constantly. However transient low cardiac output events occur during this procedure requiring aggressive volume replacement, which may lead to hypervolemia and its complications. METHOD: This study evaluates the safety and efficacy of a hypertonic-hyperoncotic NaCl solution (6% hydroxyethylamide + 7.5% sodium chloride) versus isotonic saline during the creation of anastomosis in the lateral wall of the left ventricle. In each case, 250 ml of solution was administered from coded bags at the start of the grafting procedure. All staff directly connected with the surgical procedure and post-operative management of patients was blinded to the coding. The primary objective was the determination of post-surgery complications. Secondary objectives were the determination of mean arterial blood pressure and central venous pressure during anastomotic grafting. RESULTS: Primary objectives showed no difference between hypertonic versus isotonic saline in post-operatory surgery complication. Significant increases of mean arterial pressure and central venous pressure in the Hypertonic Saline group versus normal saline patients during grafting were observed. CONCLUSION: The use of hypertonic saline during off-pump coronary artery bypass grafting on the lateral posterior wall of the left ventricle led to no complications and improved arterial and central venous pressure, favoring the creation of anastomosis in this wall.

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RETRACTED: Cardiorespiratory responses to hypertonic saline solution in cardiac operations

Cited by 53 publications

References 18 publications

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

Donor Pretreatment With Hypertonic Saline Attenuates Primary Allograft Dysfunction

Small Volume Hypertonic Resuscitation of Circulatory Shock

Safety and efficacy of hypertonic saline versus isotonic saline solution in off-pump coronary artery bypass grafting

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