RETRACTED: Centella asiatica extract in carboxymethyl cellulose at its optimal concentration improved wound healing in mice models

Tanga, Bereket Molla; Bang, Seonggyu; Fang, Xun; Seo, Chaerim; Zoysa, Mahanama De; Saadeldin, Islam M.; Lee, Sanghoon; Park, Sang Un; Chung, Sun–Ok; Lee, Geung–Joo; Cho, Jongki

doi:10.1016/j.heliyon.2022.e12031

Cited by 5 publications

(4 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[5] Some medicinal plants have been used for wound healing for a long history in humans and wild animals, which have good prospects in terms of availability and relatively low side effects. [16] Nowadays, there have been studies on alginate and gelatin carrying a pure component of a plant. [17] However, there are many difficulties in purification, including complex extraction steps, high cost, low purification efficiency, single active ingredient, etc.…”

Section: Introductionmentioning

confidence: 99%

“…[ 19 ] However, the extraction of various pure active ingredients from CA is complex and costly, which reduces the bioavailability of CA. [ 16 ] The extract derived from CA is known to contain a diverse array of natural bioactive compounds. [ 20 ] The use of extract from plants instead of pure components not only simplifies the acquisition method and reduces the cost remarkably, but also makes the various active agents work together.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Wang,

Zhang,

Song

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

How to promote wound healing is still a major challenge in the healthcare while macrophages are a critical component of the healing process. Compared to various bioactive drugs, many plants have been reported to facilitate the wound healing process by regulating the immune response of wounds. In this work, a 3D printed hydrogel scaffold loaded with natural Centella asiatica extract (CA extract) is developed for wound healing. This CA@3D scaffold uses gelatin and sodium alginate with CA extract as bio‐ink for 3D printing. The CA extract contains a variety of bioactive compounds that make the various active ingredients in Centella asiatica work in concert. The printed CA@3D scaffold can fit the shape of wound, orchestrate the macrophages and immune responses within the wound, and promote wound healing compared to commercial wound dressings. The underlying mechanism of promoting wound healing was also illuminated by applying multi‐omic analyses. Moreover, the CA extract loaded 3D scaffold also showed great ability to promote wound healing in diabetic chronic wounds. Due to its ease of preparation, low‐cost, biosafety, and therapeutic outcomes, this work proposes an effective strategy for promoting chronic wound healing.This article is protected by copyright. All rights reserved

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Wang,

Zhang,

Song

et al. 2024

Adv Healthcare Materials

View full text Add to dashboard Cite

show abstract

“…Pennywort ( Centella asiatica L.) is a herb that is commonly consumed in South China, Southeast Asia and South Asia. For centuries, this herb is used to treat a range of ailments ( Brinkhaus et al, 2000 ), including chronic venous insufficiency, striae gravidarum, wound healing and skin diseases ( Gohil et al, 2010 , Tanga et al, 2022 ). More than 130 secondary metabolites have been isolated from pennywort, including at least 18 flavonoids and 13 phenolic compounds ( Kunjumon et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

Morphological, phytochemical and genetic characterization of Centella asiatica accessions collected throughout Vietnam and Laos

Truong,

Ho,

et al. 2024

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

“…This plant can be consumed raw as a salad, and also used for treating various diseases, including brain tonic, Alzheimer, memory improvement, healthy aging, stomachache, cough, inflammation, muscle soreness, asthma, leprosy, fever, and blood booster (Gray et al, 2017;Sabaragamuwa et al, 2018;Thakurdesai, 2021;Verma et al, 2021;Seong et al, 2023;ShanmugaPriya et al, 2023). Additionally, C. asiatica has several biological activities such as wound healing, anti-inflammatory, anticancer, antioxidant, antimicrobial, antidiabetic, anti-amnesic, and anticholinergic activities (Arora et al, 2018;Wong and Ramli, 2021;Tripathy et al, 2022;Tanga et al, 2022;Arribas-López et al, 2022;Yi et al, 2023). These biological activities are due to the presence of bioactive metabolites such as triterpenoid, saponin, alkaloid, phenolic, flavonoid, tannin, steroid, and glycoside (Belwal et al, 2019;Ren et al, 2021;Mohapatra et al, 2021;Kunjumon et al, 2022;Masi et al, 2022;Zheng et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and metabolite changes in Centella asiatica with different drying methods using FTIR- and quantitative HPLC-based metabolomics

Nomi,

Handayani,

Khuluk

et al. 2024

IFRJ

View full text Add to dashboard Cite

Centella asiatica, known as Indian or Asiatic pennywort, is consumed raw as salad or used as a brain tonic, treatment of Alzheimer’s disease, and memory improvement. Differences in the drying method will lead to different levels of phytochemical profile and biological activity. Therefore, the present work aimed to investigate the Fourier transforms infrared (FTIR) spectra fingerprint profiles, HPLC analysis of four bioactive compounds, and antioxidant activity of C. asiatica samples exposed to various drying methods, including air-, oven-, and sun-drying. Results showed that all samples had identical FTIR spectra patterns, but there were differences in the absorbance intensities at 1692 and 1634 cm-1, showing the effect of drying methods on the content of extracts’ bioactive compounds. These differences were analysed by chemometrics namely principal components analysis (PCA), and groupings were shown for the three samples. Based on the IC50 values, oven-drying (OD) had the highest antioxidant activity, followed by sun-drying (SD) and air-drying (AD), with IC50 values of 52.25, 94.18, and 99.29 μg/mL, respectively. HPLC analysis showed that OD had a higher percentage for madecassoside and asiaticoside with values of 0.86 and 0.96%, respectively, compared to SD and AD. Meanwhile, AD had the highest content of madecassic and asiatic acids, with values of 0.50 and 0.48%. The absorbance and antioxidant activity data for the three C. asiatica extracts were analysed for the correlation using an orthogonal partial least square. Results showed that at 1006 - 989 cm-1, it positively correlated with antioxidant activity, and could be identified as the C–O functional group of alcohol and phenol.

show abstract

RETRACTED: Centella asiatica extract in carboxymethyl cellulose at its optimal concentration improved wound healing in mice models

Cited by 5 publications

References 60 publications

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

A Printable Hydrogel Loaded with Medicinal Plant Extract for Promoting Wound Healing

Morphological, phytochemical and genetic characterization of Centella asiatica accessions collected throughout Vietnam and Laos

Antioxidant activity and metabolite changes in Centella asiatica with different drying methods using FTIR- and quantitative HPLC-based metabolomics

Contact Info

Product

Resources

About