RETRACTED: Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial

Badawy, Ahmed; Nashar, Abu Baker El; Totongy, Mohamed

doi:10.1016/j.fertnstert.2006.02.097

Cited by 37 publications

(28 citation statements)

References 27 publications

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“…Adjuvants to CC that are used to improve its performance, such as N-acetyl cysteine, have been used successfully in patients with PCOS (5) but not in the setting of unexplained infertility (6). Alternatives to CC, such as insulin-sensitizing drugs, for example, anastrozole (2.2 0 [5-(1H-1,2,4-triazol-1-ylmethyl]-1,3-phenlene]bis(2-methylpropiononitrile), have been used for ovulation induction in case of CC failure.…”

mentioning

confidence: 99%

RETRACTED: Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovary syndrome? A prospective controlled trial

Badawy

Aal

Abulatta

2009

Fertility and Sterility

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confidence: 99%

RETRACTED: Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovary syndrome? A prospective controlled trial

Badawy

Aal

Abulatta

2009

Fertility and Sterility

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“…Clomiphene citrate may have a negative effect on the cervical mucus and endometrium and is associated with a discrepancy between ovulation and conception rates (3,4). Adjuvants to CC such as N-acetyl cysteine (NAC) were used successfully in patients with PCOS (5), but not in the setting of unexplained infertility (6).…”

mentioning

confidence: 99%

RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial

Badawy¹,

Mosbah²,

Shady³

2008

Fertility and Sterility

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“…The significant pregnancy outcome relative to control in the current study is similar to the one obtained by Howard et al even though theirs was on unexplained infertility but differ from other randomised control trials which did not show significant difference in pregnancy rates. 28,[29][30][31] Most of the earlier studies used either minerals or vitamins as their supplement but in the current study a combination of minerals, vitamins and other antioxidants were used which may be responsible for the difference in outcome even though the index study was on PCOS patients. The antioxidant vitamins such as vitamins A, C, E and minerals such as zinc and copper are important in restoring and maintaining the oxidant and antioxidant balance in blood and tissue.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

Panti

Shehu

Saidu

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: PCOS is a condition with significant decrease in antioxidant with an increased risk of oxidative stress. Antioxidant supplementation has been shown to improve insulin sensitivity in PCOS and may improve outcome of management of PCOS. Objectives of this study were to determine the oxidative stress level of PCOS patients, to assess the effect of antioxidant supplementation on the outcome of management of PCOS and to compare with a control group.Methods: The study was a single blind randomised control trial involving 200 patients with PCOS. The study was conducted at Usmanu Danfodiyo University Teaching Hospital Sokoto. They were randomly divided into intervention and control groups and base line serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals were determined. Antioxidant supplementation and placebo were given to the intervention and control groups respectively. All the patients had ovulation induction with clomiphene citrate and were followed up for 6 months. Outcome measures were clinical pregnancy or menstrual regularisation. Level of significance was <0.05.Results: There was statistical significance in the serum levels of oxidative stress marker, antioxidant enzymes, vitamins and minerals between the two groups (post intervention). Glutathione peroxidase (p = 0.001), superoxide dismutase (p = 0.0001), catalase (p= 0.0369), melondialdehyde (p= 0.007), Vitamin A, Vitamin C, Vitamin E (p = 0.0001), zinc and copper (p = 0.0001). The clinical pregnancy outcomes were 22 (22%) versus 2 (2%); live births 18 (18%) versus 2 (2%) and menstrual regularisation 48 (48%) versus 46 (46%) in the intervention and control groups respectively.Conclusions: Antioxidant supplementation in this study significantly affected pregnancy rate in patients with PCOS. Larger studies are suggested to revisit the conclusion of the Cochrane review that antioxidants supplementation had no significant role in female infertility.

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RETRACTED: Clomiphene citrate plus N-acetyl cysteine versus clomiphene citrate for augmenting ovulation in the management of unexplained infertility: a randomized double-blind controlled trial

Cited by 37 publications

References 27 publications

RETRACTED: Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovary syndrome? A prospective controlled trial

RETRACTED: Clomiphene citrate or anastrozole for ovulation induction in women with polycystic ovary syndrome? A prospective controlled trial

RETRACTED: Anastrozole or letrozole for ovulation induction in clomiphene-resistant women with polycystic ovarian syndrome: a prospective randomized trial

Oxidative stress and outcome of antioxidant supplementation in patients with polycystic ovarian syndrome (PCOS)

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