RETRACTED: Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish

Boopathi, Seenivasan; Haridevamuthu, B.; Mendonca, Edrea; Gandhi, Akash; Priya, P. Snega; Alkahtani, Saad; AL–Johani, Norah S.; Arokiyaraj, Selvaraj; Guru, Ajay; Arockiaraj, Jesu; Malafaia, Guilherme

doi:10.1016/j.scitotenv.2023.165988

Cited by 27 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, multiple models have demonstrated that the liver can be insulted by MPs through ROS generation, directly or indirectly resulting in MAFLD. In zebrafish models, combined exposure to a high-fat diet and MPs increased oxidative stress and upregulated lipogenic and inflammatory gene expression, which led to steatotic liver and altered behaviors[ 14 ]. Co-exposure of MPs with antibiotic pollutants in zebrafish exhibited significantly higher levels of lipid accumulation and inflammation in conjunction with oxidative stress production in their livers[ 15 ].…”

Section: Oxidative Stressmentioning

confidence: 99%

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang,

Yeh,

Shiu

et al. 2024

World J Gastroenterol

View full text Add to dashboard Cite

With continuous population and economic growth in the 21st century, plastic pollution is a major global issue. However, the health concern of microplastics/ nanoplastics (MPs/NPs) decomposed from plastic wastes has drawn public attention only in the recent decade. This article summarizes recent works dedicated to understanding the impact of MPs/NPs on the liver-the largest digestive organ, which is one of the primary routes that MPs/NPs enter human bodies. The interrelated mechanisms including oxidative stress, hepatocyte energy re-distribution, cell death and autophagy, as well as immune responses and inflammation, were also featured. In addition, the disturbance of microbiome and gut-liver axis, and the association with clinical diseases such as metabolic dysfunction-associated fatty liver disease, steatohepatitis, liver fibrosis, and cirrhosis were briefly discussed. Finally, we discussed potential directions in regard to this trending topic, highlighted current challenges in research, and proposed possible solutions.

show abstract

Section: Oxidative Stressmentioning

confidence: 99%

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Chiang,

Yeh,

Shiu

et al. 2024

World J Gastroenterol

View full text Add to dashboard Cite

show abstract

“…Fish were acclimatized for a period of approximately 21 days under laboratory conditions as previously described (Boopathi et al, 2023).…”

Section: Animal Housingmentioning

confidence: 99%

Daidzein ameliorates nonmotor symptoms of manganese‐induced Parkinsonism in zebrafish model: Behavioural and biochemical approach

Haridevamuthu,

Sudhakaran,

Pachaiappan

et al. 2024

British J Pharmacology

Self Cite

View full text Add to dashboard Cite

Background and PurposeParkinson's disease (PD) is a prevalent neurodegenerative movement disorder characterized by motor dysfunction. Environmental factors, especially manganese (Mn), contribute significantly to PD. Existing therapies are focused on motor coordination, whereas nonmotor features such as neuropsychiatric symptoms are often neglected. Daidzein (DZ), a phytoestrogen, has piqued interest due to its antioxidant, anti‐inflammatory, and anxiolytic properties. Therefore, we anticipate that DZ might be an effective drug to alleviate the nonmotor symptoms of Mn‐induced Parkinsonism.Experimental ApproachNaïve zebrafish were exposed to 2 mM of Mn for 21 days and intervened with DZ. Nonmotor symptoms such as anxiety, social behaviour, and olfactory function were assessed. Acetylcholinesterase (AChE) activity and antioxidant enzyme status were measured from brain tissue through biochemical assays. Dopamine levels and histology were performed to elucidate neuroprotective mechanism of DZ.Key ResultsDZ exhibited anxiolytic effects in a novel environment and also improved intra and inter fish social behaviour. DZ improved the olfactory function and response to amino acid stimuli in Mn‐induced Parkinsonism. DZ reduced brain oxidative stress and AChE activity and prevented neuronal damage. DZ increased DA level in the brain, collectively contributing to neuroprotection.Conclusion and ImplicationsDZ demonstrated a promising effect on alleviating nonmotor symptoms such as anxiety and olfactory dysfunction, through the mitigation of cellular damage. These findings underscore the therapeutic potential of DZ in addressing nonmotor neurotoxicity induced by heavy metals, particularly in the context of Mn‐induced Parkinsonism.

show abstract

Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats

Yi,

Mai,

Fang

et al. 2024

J Biochem & Molecular Tox

View full text Add to dashboard Cite

With the gradual emergence of xylazine as a street drug, incidents of xylazine poisoning are now occurring worldwide. However, it remains unknown whether long‐term exposure to xylazine causes nonalcoholic fatty liver disease (NAFLD). In the present study, the rats were injected with xylazine intraperitoneally for 28 consecutive days, and then serum and liver tissues were collected for analysis. Weight loss was observed in the 40 mg/kg group and elevated levels of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were observed. Histopathologic examination showed hepatic steatosis, necrosis, and fibrosis. By mRNA sequencing, 192 upregulated genes and 277 downregulated genes were found in the 40 mg/kg group, and the PPAR signaling pathway was ranked first in the KEGG pathway analysis. Four genes in the PPAR signaling pathway, Fabp5, Acox2, and Cpt2, were also verified in the 40 mg/kg group by RT‐qPCR analysis and western blot. Our results demonstrated that long‐term injection of xylazine causes NAFLD and the PPAR signaling pathway plays a core role in the process of xylazine‐associated liver injury.

show abstract

RETRACTED: Combined effects of a high-fat diet and polyethylene microplastic exposure induce impaired lipid metabolism and locomotor behavior in larvae and adult zebrafish

Cited by 27 publications

References 50 publications

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Impact of microplastics and nanoplastics on liver health: Current understanding and future research directions

Daidzein ameliorates nonmotor symptoms of manganese‐induced Parkinsonism in zebrafish model: Behavioural and biochemical approach

Repeated Injection of Xylazine Causes Liver Injury Through the PPAR Signaling Pathway in Rats

Contact Info

Product

Resources

About