[Retracted] Correlation Analysis of Cytochrome P450 SNPs in Hepatitis B‐Caused Cirrhosis Patients

Abstract

Aim. The aim of the present research was to find the correlation of single nucleotide polymorphisms (SNPs) of cytochrome P450 (CYP450) and hepatitis B-caused cirrhosis. Methods. Collection of specimens was done from 297 volunteers with confirmed hepatitis B-caused cirrhosis as well as 120 healthy volunteers in China. Individuals were categorized into three classes, i.e., A, B, and C, on the basis of the Child-Pugh-Turcotte (CPT) value of diseased people, while the Child-Pugh-Turcotte score was determined by rating the below mentioned 5 parameters, i.e., serum volume of bilirubin as well as albumin, prothrombin time, ascites, and encephalopathy. Twenty-four SNPs in the CYP450 superfamily including CYP1A2, CYP2A6, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CY3A4 were detected using the SNaPshot assay. Results. CYP1A2-G2964A, CYP1A2-C733A, and CYP1A2-T5347C in all 24 SNP loci attained significance. AA genotype at CYP1A2-G2964A (P=0.048) and CC genotype at CYP1A2-T5347C (P=0.049) were significantly correlated with hepatitis B-caused cirrhosis. Moreover, an allele at CYP1A2-G2964A (P=0.032) and C allele at CYP1A2-T5347C (P=0.016) were associated with hepatitis B-caused cirrhosis. Furthermore, AC plus AA genotype at CYP1A2-C733A correlated with a TCM syndrome, “damp abundance due to spleen asthenia syndrome” (P=0.039) in individuals suffering from hepatitis B-resulted cirrhosis. Conclusion. The findings of the current study suggested that AA genotype at CYP1A2-G2964A and CC genotype at CYP1A2-T5347C may be higher risk in the occurrence of hepatitis B-caused cirrhosis. Moreover, patients with AC plus AA genotype at CYP1A2-C733A may be susceptible to appear having “damp abundance due to spleen asthenia syndrome.”

Retracted: Correlation Analysis of Cytochrome P450 SNPs in Hepatitis B-Caused Cirrhosis Patients

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”