RETRACTED: Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury‐Induced Lumbar Facet Joint Osteoarthritis

Kim, Jae Sung; Ahmadinia, Kasra; Li, Xin; Hamilton, John; Andrews, Steven W.; Haralampus, Chris A.; Xiao, Guozhi; Sohn, Hong Moon; You, Jae Won; Seo, Yo Seob; Stein, Gary S.; Wijnen, André J. van; Kim, Su Gwan; Im, Hee Jeong

doi:10.1002/jcp.25015

Cited by 31 publications

(36 citation statements)

References 46 publications

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“…[41] Additionally, activity levels examined by voluntary wheel running may be particularly important in the development of novel rodent models of discogenic neuropathic pain [42] as alternative hind-paw allodynia and hyperalgesia assays may not fully capture the spectrum of pain behaviors from neuropathy in this model.…”

Section: Discussionmentioning

confidence: 99%

Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia

Whitehead

Lam

Sun

et al. 2017

Anesthesia &Amp; Analgesia

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BACKGROUND Animal models of peripheral neuropathy produced by a number of manipulations are assessed for the presence of pathological pain states such as allodynia. While stimulus-induced behavioral assays are frequently used and important to examine allodynia (i.e. sensitivity to light mechanical touch; von Frey fiber test) other measures of behavior that reflect overall function are not only complementary to stimulus-induced responsive measures, but are also critical to gain a complete understanding of the effects of the pain model on quality of life, a clinically relevant aspect of pain on general function. Voluntary wheel running activity in rodent models of inflammatory and muscle pain is emerging as a reliable index of general function that extends beyond stimulus-induced behavioral assays. Clinically, reports of increased pain intensity occur at night, a period typically characterized with reduced activity during the diurnal cycle. We therefore examined in rats whether alterations in wheel running activity were more robust during the inactive phase compared to the active phase of their diurnal cycle in a widely used rodent model of chronic peripheral neuropathic pain, the sciatic nerve chronic constriction injury (CCI) model. METHODS In adult male Sprague Dawley rats, baseline (BL) hindpaw threshold responses to light mechanical touch were assessed using the von Frey test prior to measuring BL activity levels using freely accessible running wheels (1 hr/day for 7 sequential days) to quantify distance traveled. Running wheel activity BL values are expressed as total distance traveled (m). The overall experimental design was: following BL measures, rats underwent either sham or CCI surgery followed by repeated behavioral re-assessment of hindpaw thresholds and wheel running activity levels for up to 18 days after surgery. Specifically, separate groups of rats were assessed for wheel running activity levels (1 hr total/trial) during the onset (within first 2 hrs) of either the (1) inactive (n=8/gp) or (2) active (n = 8/gp) phase of the diurnal cycle. An additional group of CCI-treated rats (n = 8/gp) were exposed to a locked running wheel to control for the potential effects of wheel running exercise on allodynia. The 1-hr running wheel trial period was further examined at discrete 20-min intervals to identify possible pattern differences in activity during the first, middle and last portion of the 1-hr trial. The effect of neuropathy on activity levels were assessed by measuring the change from their respective BLs to distance traveled in the running wheels. RESULTS While wheel running distances between groups were not different at BL from rats examined during either the inactive phase of the diurnal cycle or active phase of the diurnal cycle, sciatic nerve CCI reduced running wheel activity levels compared to sham-operated controls during the inactive phase. Additionally, compared to sham controls, bilateral low threshold mechanical allodynia was observed at all time-points after surgical induction of...

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Section: Discussionmentioning

confidence: 99%

Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia

Whitehead

Lam

Sun

et al. 2017

Anesthesia &Amp; Analgesia

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“…Kim et al () used MIA to induce back pain as a result of lumbar facet joint osteoarthritis. This group recently developed another model that involved puncture‐induced injury to the lumbar facet joint, which reproduced a spectrum of signs and symptoms that are displayed in human chronic back pain patients (Kim et al, ). Although these models of back pain are relatively new, animal models of visceral pain have been in use for nearly three decades.…”

Section: Animal Models Of Painmentioning

confidence: 99%

Animal models of chronic pain: Advances and challenges for clinical translation

Burma

Leduc‐Pessah

Fan

et al. 2016

J of Neuroscience Research

167

117

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Chronic pain is a global problem that has reached epidemic proportions. An estimated 20% of adults suffer from pain, and another 10% are diagnosed with chronic pain each year (Goldberg and McGee, ). Despite the high prevalence of chronic pain (an estimated 1.5 billion people are afflicted worldwide), much remains to be understood about the underlying causes of this condition, and there is an urgent requirement for better pain therapies. The discovery of novel targets and the development of better analgesics rely on an assortment of preclinical animal models; however, there are major challenges to translating discoveries made in animal models to realized pain therapies in humans. This review discusses common animal models used to recapitulate clinical chronic pain conditions (such as neuropathic, inflammatory, and visceral pain) and the methods for assessing the sensory and affective components of pain in animals. We also discuss the advantages and limitations of modeling chronic pain in animals as well as highlighting strategies for improving the predictive validity of preclinical pain studies. © 2016 Wiley Periodicals, Inc.

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“…Recently, hypersensitivity of the skin has been detected in human patients and preclinical animal models of osteoarthritis, low back pain, and bone cancer pain [4; 33; 43; 56; 58; 59; 72]. Given that skin hypersensitivity can be measured much more quickly and easily than skeletal pain-related behaviors, a major question is whether skeletal pain-induced hypersensitivity of the skin is an appropriate and reliable surrogate for assessing skeletal pain.…”

Section: Introductionmentioning

confidence: 99%

Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain

Guedon

Longo

Majuta

et al. 2016

Pain

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Recent studies have suggested that in humans and animals with significant skeletal pain, changes in the mechanical hypersensitivity of the skin can be detected. However, whether measuring changes in skin hypersensitivity can be a reliable surrogate for measuring skeletal pain itself remains unclear. To explore this question we generated skeletal pain by injecting and confining GFP-transfected NCTC 2472 osteosarcoma cells unilaterally to the femur of C3H male mice. Beginning at day 7 post-tumor injection, animals were administered vehicle, an antibody to the P2X3 receptor (anti-P2X3) or anti-NGF antibody. Pain and analgesic efficacy was then measured on days 21, 28 and 35 post-tumor injection using a battery of skeletal pain-related behaviors and von Frey assessment of mechanical hypersensitivity on the plantar surface of the hindpaw. Animals with bone cancer pain treated with anti-P2X3 showed a reduction in skin hypersensitivity but no attenuation of skeletal pain behaviors. Whereas animals with bone cancer pain treated with anti-NGF showed a reduction in both skin hypersensitivity and skeletal pain behaviors. These results suggest that while bone cancer can induce significant skeletal pain-related behaviors and hypersensitivity of the skin, relief of hypersensitivity of the skin is not always accompanied by attenuation of skeletal pain. Understanding the relationship between skeletal and skin pain may provide insight into how pain is processed and integrated and help define the preclinical measures of skeletal pain that are predictive endpoints for clinical trials.

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RETRACTED: Development of an Experimental Animal Model for Lower Back Pain by Percutaneous Injury‐Induced Lumbar Facet Joint Osteoarthritis

Cited by 31 publications

References 46 publications

Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia

Chronic Sciatic Neuropathy in Rat Reduces Voluntary Wheel-Running Activity With Concurrent Chronic Mechanical Allodynia

Animal models of chronic pain: Advances and challenges for clinical translation

Dissociation between the relief of skeletal pain behaviors and skin hypersensitivity in a model of bone cancer pain

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