RETRACTED: Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway

Miltonprabu, Selvaraj; Sumedha, Naorem Chanu; Senthilraja, P.

doi:10.1016/j.intimp.2017.06.011

Cited by 48 publications

(33 citation statements)

References 40 publications

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“…Therefore, the anti-cancer activity of polysulfide donors and combination with cisplatin were examined. Like garlic derived organic polysulfide [36] , these inorganic polysulfide donors (Na 2 S 2 , Na 2 S 3 and Na 2 S 4 ) also exhibit selective cancer cell killing effect in NSCLC cell lines. Notably, combination of polysulfide donor Na 2 S 4 and cisplatin resulted in stronger anti-cancer effect in NSCLC cell lines like H1299 and A549 which may also rule out the possible reaction between sulfur containing polysulfide and cisplatin [37] in our experimental settings.…”

Section: Discussionmentioning

confidence: 99%

Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity

et al. 2018

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Cisplatin is a major chemotherapeutic drug for solid tumors whereas it may lead to severe nephrotoxicity. Despite decades of efforts, effective therapies remain largely lacking for this disease. In the current research, we investigated the therapeutic effect of hydrogen polysulfide, a novel hydrogen sulfide (H2S) derived signaling molecule, in cisplatin nephrotoxicity and the mechanisms involved. Our results showed that polysulfide donor Na2S4 ameliorated cisplatin-caused renal toxicity in vitro and in vivo through suppressing intracellular reactive oxygen species (ROS) generation and downstream mitogen-activated protein kinases (MAPKs) activation. Additionally, polysulfide may inhibit ROS production by simultaneously lessening the activation of NADPH oxidase and inducing nucleus translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) in RPT cells. Interestingly, polysulfide possesses anti-cancer activity and is able to add on more anti-cancer effect to cisplatin in non-small cell lung cancer (NSCLC) cell lines. Moreover, we observed that the number of sulfur atoms in polysulfide well reflected the efficacy of these molecules not only in cell protection but also cancer inhibition which may serve as a guide for further development of polysulfide donors for pharmaceutical usage. Taken together, our study suggests that polysulfide may be a novel and promising therapeutic agent to prevent cisplatin-induced nephrotoxicity.

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Section: Discussionmentioning

confidence: 99%

Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity

et al. 2018

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“…H 2 S released from organic trisulfides might influence protein-associated metal atoms too ( 13 ). Organic trisulfides were reported to exert antioxidant and anti-inflammatory effects mostly studied in animal models of inflammatory bowel disease ( 14 – 16 ). Inorganic POLYs are known to interact with functional cysteines of the TRPA1 ion channel ( 17 ).…”

Section: Introductionmentioning

confidence: 99%

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide

et al. 2018

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Transient receptor potential ankyrin 1 (TRPA1) non-selective ligand-gated cation channels are mostly expressed in primary sensory neurons. Polysulfides (POLYs) are Janus-faced substances interacting with numerous target proteins and associated with both protective and detrimental processes. Activation of TRPA1 in sensory neurons, consequent somatostatin (SOM) liberation and action on sst4 receptors have recently emerged as mediators of the antinociceptive effect of organic trisulfide dimethyl trisulfide (DMTS). In the frame of the present study, we set out to compare the participation of this mechanism in antinociceptive and anti-inflammatory effects of inorganic sodium POLY and DMTS in carrageenan-evoked hind-paw inflammation. Inflammation of murine hind paws was induced by intraplantar injection of carrageenan (3% in 30 µL saline). Animals were treated intraperitoneally with POLY (17 µmol/kg) or DMTS (250 µmol/kg) or their respective vehicles 30 min prior paw challenge and six times afterward every 60 min. Mechanical pain threshold and swelling of the paws were measured by dynamic plantar aesthesiometry and plethysmometry at 2, 4, and 6 h after initiation of inflammation. Myeloperoxidase (MPO) activity in the hind paws were detected 6 h after challenge by luminescent imaging. Mice genetically lacking TRPA1 ion channels, sst4 receptors and their wild-type counterparts were used to examine the participation of these proteins in POLY and DMTS effects. POLY counteracted carrageenan-evoked mechanical hyperalgesia in a TRPA1 and sst4 receptor-dependent manner. POLY did not influence paw swelling and MPO activity. DMTS ameliorated all examined inflammatory parameters. Mitigation of mechanical hyperalgesia and paw swelling by DMTS were mediated through sst4 receptors. These effects were present in TRPA1 knockout animals, too. DMTS inhibited MPO activity with no participation of the sensory neuron–SOM axis. While antinociceptive effects of POLY are transmitted by activation of peptidergic nerves via TRPA1, release of SOM and its effect on sst4 receptors, those of DMTS partially rely on SOM release triggered by other routes. SOM is responsible for the inhibition of paw swelling by DMTS, but TRPA1 does not contribute to its release. Modulation of MPO activity by DMTS is independent of TRPA1 and sst4.

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“…Diallyl trisulfide showed protective effects against H 2 O 2 toxicity at concentrations of 12.5 and 25 µM, but against NaAsO 2 toxicity it induced lethality, even at 5 µM, suggesting the cotoxicity of diallyl trisulfide and arsenite. Previous reports showed that diallyl trisulfide not only ameliorates H 2 O 2 toxicity in C2C12 skeletal muscle myoblast cells in a Nrf2-dependent manner [45], but also protects the rat liver from arsenic acid damage [46]. It is not known whether this discrepancy is due to the difference in arsenic forms, tissues/cells or species.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

Endo

Muraki

Fuse

2020

IJMS

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Various dietary phytochemicals seem to display antioxidant activity through the NF-E2-related factor 2 (Nrf2) pathway. However, few studies have demonstrated its antioxidant effect and Nrf2 dependency at the animal level. We constructed a zebrafish-based assay system to analyze the in vivo antioxidant activity of phytochemicals and examined the activity of 10 phytochemicals derived from spices, using this system as a pilot study. Hydrogen peroxide and arsenite were used as oxidative stressors, and Nrf2 dependency was genetically analyzed using an Nrf2-mutant zebrafish line. The activities of curcumin, diallyl trisulfide and quercetin were involved in the reduction of hydrogen peroxide toxicity, while those of cinnamaldehyde, isoeugenol and 6-(methylsulfinyl)hexyl isothiocyanate were involved in the reduction of arsenite toxicity. The antioxidant activities of these phytochemicals were all Nrf2 dependent, with the exception of cinnamaldehyde, which showed strong antioxidant effects even in Nrf2-mutant zebrafish. In summary, we succeeded in constructing an assay system to evaluate the in vivo antioxidant activity of various phytochemicals using zebrafish larvae. Using this system, we found that each spice-derived phytochemical has its own specific property and mechanism of antioxidant action.

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RETRACTED: Diallyl trisulfide, a garlic polysulfide protects against As-induced renal oxidative nephrotoxicity, apoptosis and inflammation in rats by activating the Nrf2/ARE signaling pathway

Cited by 48 publications

References 40 publications

Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity

Renal protective effect of polysulfide in cisplatin-induced nephrotoxicity

Role of Transient Receptor Potential Ankyrin 1 Ion Channel and Somatostatin sst4 Receptor in the Antinociceptive and Anti-inflammatory Effects of Sodium Polysulfide and Dimethyl Trisulfide

Evaluation of Antioxidant Activity of Spice-Derived Phytochemicals Using Zebrafish

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