RETRACTED: Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia

Ma, Haiying; Zhou, Huimin; Song, Xianmin; Xing, Miao; Li, Yanping; Li, Jia

doi:10.1016/j.bbadis.2014.06.014

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…A positive correlation between ROS production and MDR transporter expression have been reported indicating high concentrations of ROS induce MRP1 (73). MRP1 expression has been found to be regulated by the PI3K/Akt pathway (74). Genistein increased daunorubicin accumulation in a doxorubicin-resistant small-cell lung cancer cell line (67).…”

Section: Natural Product Modulatorsmentioning

confidence: 97%

Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Çört

Özben

2015

Nutrition and Cancer

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Multidrug resistance (MDR) is a condition that makes cells simultaneously unresponsive to different drugs, unrelated to their chemical structure and mechanism of action. MDR caused by the presence and overexpression of ABC transporters makes obstacles in cancer treatment and lower the effectiveness of chemotherapy. Natural products are investigated by many researchers as MDR modulators for their low toxicity and potent, selective behavior. When coadministered, MDR modulators compete with cytotoxic agents for binding to the active site of the membrane transporters and reduce drug efflux. Natural product-based drugs are important in struggling against drug resistance during cancer therapy. This review is focused on the potential mechanisms against drug resistance, the development of inhibitors for ABC drug transporters, natural product modulators, and nanoparticle drug delivery.

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Section: Natural Product Modulatorsmentioning

confidence: 97%

Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Çört

Özben

2015

Nutrition and Cancer

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“…Some of these models include the overexpression of glycosyltransferases, which has allowed the characterization of the biosynthesis and function of simple cancer-associated carbohydrate epitopes, such as Tn, STn, T, and ST ( 17 , 18 , 20 , 141 , 142 ). Similar strategies have used stably transfected cell lines with glycosyltransferases to characterize the function of branched glycan structures ( 52 , 56 ) as well as terminal sialylated/fucosylated structures frequently overexpressed by cancer cells, as previously explained in Section “ Increased Sialylation and Fucosylation ” ( 67 , 143 , 144 ).…”

Section: Innovative Glycobiological Strategiesmentioning

confidence: 99%

Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer

et al. 2016

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Gastrointestinal (GI) cancer is the most common group of malignancies and many of its types are among the most deadly. Various glycoconjugates have been used in clinical practice as serum biomarker for several GI tumors, however, with limited diagnose application. Despite the good accessibility by endoscopy of many GI organs, the lack of reliable serum biomarkers often leads to late diagnosis of malignancy and consequently low 5-year survival rates. Recent advances in analytical techniques have provided novel glycoproteomic and glycomic data and generated functional information and putative biomarker targets in oncology. Glycosylation alterations have been demonstrated in a series of glycoconjugates (glycoproteins, proteoglycans, and glycosphingolipids) that are involved in cancer cell adhesion, signaling, invasion, and metastasis formation. In this review, we present an overview on the major glycosylation alterations in GI cancer and the current serological biomarkers used in the clinical oncology setting. We further describe recent glycomic studies in GI cancer, namely gastric, colorectal, and pancreatic cancer. Moreover, we discuss the role of glycosylation as a modulator of the function of several key players in cancer cell biology. Finally, we address several state-of-the-art techniques currently applied in this field, such as glycomic and glycoproteomic analyses, the application of glycoengineered cell line models, microarray and proximity ligation assay, and imaging mass spectrometry, and provide an outlook to future perspectives and clinical applications.

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“…Although journal authorities are likely to reference the publishers' policy on retraction to justify their decisions to retract published articles, authors of retracted articles do occasionally refer to such policy, as illustrated by the example below. Consequently, the authorship of the third RN [84] remained ambiguous.…”

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confidence: 99%

Retraction Notices: Who Authored Them?

2018

Publications

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Unlike other academic publications whose authorship is eagerly claimed, the provenance of retraction notices (RNs) is often obscured presumably because the retraction of published research is associated with undesirable behavior and consequently carries negative consequences for the individuals involved. The ambiguity of authorship, however, has serious ethical ramifications and creates methodological problems for research on RNs that requires clear authorship attribution. This article reports a study conducted to identify RN textual features that can be used to disambiguate obscured authorship, ascertain the extent of authorship evasion in RNs from two disciplinary clusters, and determine if the disciplines varied in the distributions of different types of RN authorship. Drawing on a corpus of 370 RNs archived in the Web of Science for the hard discipline of Cell Biology and the soft disciplines of Business, Finance, and Management, this study has identified 25 types of textual markers that can be used to disambiguate authorship, and revealed that only 25.68% of the RNs could be unambiguously attributed to authors of the retracted articles alone or jointly and that authorship could not be determined for 28.92% of the RNs. Furthermore, the study has found marked disciplinary differences in the different categories of RN authorship. These results point to the need for more explicit editorial requirements about RN authorship and their strict enforcement.

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RETRACTED: Effect of ST3GAL 4 and FUT 7 on sialyl Lewis X synthesis and multidrug resistance in human acute myeloid leukemia

Cited by 4 publications

References 42 publications

Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Natural Product Modulators to Overcome Multidrug Resistance In Cancer

Glycomic Approaches for the Discovery of Targets in Gastrointestinal Cancer

Retraction Notices: Who Authored Them?

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