[Retracted] Effects of Dexmedetomidine and Propofol on Postoperative Analgesia and the Cellular Immune Function of Patients Undergoing Radical Gastrectomy for Gastric Cancer

Li, Rui; Suo, Shanlian; Wang, Yihan; Wang, Min

doi:10.1155/2022/7440015

Cited by 6 publications

(7 citation statements)

References 18 publications

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“…In the study by Guo et al [ 15 ], DEX outperformed epidural anesthesia in terms of sedative and analgesic effects in elderly adults undergoing RG for GC and accelerated their recovery. Liu et al [ 16 ] focused on the influence of DEX combined with propofol on postoperative analgesia and cellular immune function during RG. The combination of the two was found to suppress postoperative stress responses, improve analgesia effects, enhance immune function, and reduce the occurrence of postoperative adverse events.…”

Section: Discussionmentioning

confidence: 99%

Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia

Ma¹,

Lv²,

Wei³

et al. 2023

World J Gastrointest Surg

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BACKGROUND Radical gastrectomy (RG) is commonly used in the treatment of patients with gastric cancer (GC), but this procedure may lead to stress responses, postoperative cognitive dysfunction, and blood coagulation abnormalities in patients. AIM To investigate the influences of dexmedetomidine (DEX) on stress responses and postoperative cognitive and coagulation functions in patients undergoing RG under general anesthesia (GA). METHODS One hundred and two patients undergoing RG for GC under GA from February 2020 to February 2022 were retrospectively reviewed. Of these, 50 patients had received conventional anesthesia intervention [control group (CG)] and 52 patients had received DEX in addition to routine anesthesia intervention [observation group (OG)]. Inflammatory factor (IFs; tumor necrosis factor-α, TNF-α; interleukin-6, IL-6), stress responses (cortisol, Cor; adrenocorticotropic hormone, ACTH), cognitive function (CF; Mini-Mental State Examination, MMSE), neurological function (neuron-specific enolase, NSE; S100 calcium-binding protein B, S100B), and coagulation function (prothrombin time, PT; thromboxane B2, TXB2; fibrinogen, FIB) were compared between the two groups before surgery (T0), as well as at 6 h (T1) and 24 h (T2) after surgery. RESULTS Compared with T0, TNF-α, IL-6, Cor, ACTH, NSE, S100B, PT, TXB2, and FIB showed a significant increase in both groups at T1 and T2, but with even lower levels in OG vs CG. Both groups showed a significant reduction in the MMSE score at T1 and T2 compared with T0, but the MMSE score was notably higher in OG compared with CG. CONCLUSION In addition to a potent inhibitory effect on postoperative IFs and stress responses in GC patients undergoing RG under GA, DEX may also alleviate the coagulation dysfunction and improve the postoperative CF of these patients.

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Section: Discussionmentioning

confidence: 99%

Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia

Ma¹,

Lv²,

Wei³

et al. 2023

World J Gastrointest Surg

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“…Previous studies on DEX in GC have mostly focused on clinical aspects. Studies on DEX on postoperative analgesia and cellular immune function, 10 and postoperative cognitive function 5 in patients undergoing radical gastric cancer surgery have confirmed the safety of DEX anesthesia in surgery. However, the impact of DEX on the biological characteristics of GC cells and the mechanism underlying its action remains unknown.…”

Section: Introductionmentioning

confidence: 88%

Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR‐302a/E2F7axis

Gao¹,

Wang

2023

The Kaohsiung J of Med Scie

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Dexmedetomidine (DEX), a common anesthetic, has significant effects on the biological features of cancer cells. Although numerous studies have been published on the impact of DEX on the biological characteristics of GC cells, the mechanism remains unknown. This study aimed to explore the effect of DEX on the biological properties of GC cells. DEX suppressed the viability and increased the apoptosis of GC cells in vitro and inhibited tumor growth in vivo. Besides, DEX raised the levels of reactive oxygen species (ROS) and iron, but decreased the levels of glutathione (GSH), glutathione peroxidase 4 (GPX4), and solute carrier family 7 member 11 (SLC7A11) in GC cells, which were abolished by Ferrostatin-1 (the inhibitor of ferroptosis) treatment. In addition, the level of circ0008035 and E2F7 were downregulated, but miR-302a level was upregulated in DEX-treated GC cells. Circ0008035 increased the expression of E2F2 by acting as a sponge for miR-302a. Circ0008035 inhibited DEX-induced ferroptotic cell death in GC cells, which was reversed by miR-302a overexpression or E2F7 reduction. Taken together, DEX mediated ferroptotic cell death in GC through regulating the circ0008035/miR-302a/E2F7 axis, suggesting a feasible therapy option for GC.

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“…Além disso, essa combinação tem demonstrado reduzir as complicações e reações adversas após a cirurgia, contribuindo para uma recuperação mais rápida e eficaz do paciente (Liu et al, 2022).…”

Section: Função Imunológicaunclassified

A Escolha Dos Anestésicos Relacionado as Complicações Pós Operatórias De Cirurgias Abdominais

MARQUES ANDRADE,

ARAUJO DEBASTIANI,

ALICE CAVALCANTE SOUSA

et al. 2024

Estudos Multidisciplinares Sobre Emergência E Terapia Intensiva

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Objetivo: Investigar a influência dos anestésicos nos possíveis efeitos gerados no pós cirúrgico de cirurgias abdominais. Metodologia: Uma revisão integrativa sobre anestésicos em cirurgias colorretais, buscando determinar sua influência no pós-operatório. Dados foram coletados de diversas bases, selecionando 17 artigos após critérios rigorosos. Os resultados foram analisados quanto a complicações pós-operatórias, analgesia, dor, náusea, vômito, função imunológica e lesão renal aguda. Resultados e discussão: Destaca a importância da analgesia pós-operatória, abordando complicações como dor, náusea, vômito, função imunológica e lesão renal aguda. Destaca-se a eficácia da analgesia multimodal, o uso de lidocaína intravenosa e dexmedetomidina para controle da dor. Também são discutidas estratégias para prevenir náuseas e vômitos, incluindo a administração de antagonistas do receptor 5-HT3. Além disso, são mencionados os impactos na função imunológica e o potencial da metoxamina e sufentanil na prevenção da lesão renal aguda. Considerações finais: O manejo eficaz da dor pós-cirúrgica é essencial para a recuperação do paciente, com a analgesia multimodal sendo uma abordagem eficaz. O uso de opióides deve ser cauteloso devido aos potenciais efeitos adversos. As complicações relacionadas à NVPO representam um desafio, sendo crucial a prevenção e tratamento adequados. A função imunológica do paciente pode ser afetada pela cirurgia, destacando a importância de estratégias anestésicas que minimizem a resposta inflamatória. A administração de metoxamina é uma estratégia para reduzir a incidência de LRA pósoperatória. Essas intervenções ressaltam a importância da avaliação individualizada dos pacientes e medidas preventivas para melhorar os resultados clínicos.

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[Retracted] Effects of Dexmedetomidine and Propofol on Postoperative Analgesia and the Cellular Immune Function of Patients Undergoing Radical Gastrectomy for Gastric Cancer

Cited by 6 publications

References 18 publications

Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia

Influences of dexmedetomidine on stress responses and postoperative cognitive and coagulation functions in patients undergoing radical gastrectomy under general anesthesia

Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR‐302a/E2F7axis

A Escolha Dos Anestésicos Relacionado as Complicações Pós Operatórias De Cirurgias Abdominais

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