RETRACTED: Enhancement of learning and memory by a medicinal formulation, Saenhyetang, in mice

Jin, Un‐Ho; Kim, Jang-Hyun; Gyu-Tae, Chang; Kim, June-Ki; Chung, Kang-Hyun; Kim, Cheorl-Ho

doi:10.1016/j.jep.2006.07.030

Cited by 6 publications

(2 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is conceivable that the NR2B may serve as a valuable molecular target for possible therapeutic intervention of learning and memory impairment associated with the ageing process. (Jin et al , 2007).…”

Section: Discussionmentioning

confidence: 99%

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

Cao

Cui

Feng

et al. 2007

Eur J of Neuroscience

162

119

View full text Add to dashboard Cite

Brain ageing represents a general and evolutionarily conserved phenomenon and is marked by gradual declines in cognitive functions such as learning and memory. As a synaptic coincidence detector, the N-methyl-d-aspartate (NMDA) receptor is known to be essential for the induction of synaptic plasticity and memory formation. Here, we test the hypothesis that up-regulation of NR2B expression is beneficial for learning and memory in the aged animals. Our in vitro recordings show that the aged transgenic mice with the forebrain-specific overexpression of the NR2B subunit indeed exhibit more robust hippocampal long-term potentiation (LTP) induced by either high-frequency stimulation or theta-stimulation protocol. Furthermore, those aged NR2B transgenic mice consistently outperform their wild-type littermates in five different learning and memory tests, namely, novel object recognition, contextual and cued fear conditioning, spatial reference memory, and spatial working memory T-maze task. Thus, we conclude that increased expression of NR2B in the forebrain improves learning and memory function in the aged brain.

show abstract

Section: Discussionmentioning

confidence: 99%

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

Cao

Cui

Feng

et al. 2007

Eur J of Neuroscience

162

119

View full text Add to dashboard Cite

show abstract

“… 1 Within the last decade, many investigations have been focused on the effects of drugs, including herbal drugs, on the learning process. 2 Piperine is a major alkaloid of black pepper ( Piper nigrum ), which is used as a pungent food additive, flavoring, and antiflatulent in Iranian folk medicine. Piper species have been used in folk medicine for the treatment of various diseases.…”

Section: Introductionmentioning

confidence: 99%

Effect of breastfeeding piperine on the learning of offspring mice: interaction with caffeine and diazepam

Moghadamnia¹

2010

JEP

View full text Add to dashboard Cite

Piperine, the main alkaloid of black pepper (Piper nigrum), has been suggested to display several pharmacological properties, including pain relief, anticonvulsant, antidepressant-like, antianxiety, sedative, and anti-inflammatory effects. This study was designed to investigate the effect of piperine on learning in mice and the interaction of the effect with caffeine and diazepam. Piperine (100 mg/kg intraperitoneally) was injected into the mouse mothers or nursing dams during breastfeeding for 25 days at five-day intervals. After feeding the newborn mice, their learning was evaluated using a step-through passive avoidance task. Mouse learning was assessed 1 hr and 24 hr and 1 week after a training session. Piperine increased learning in the first (1 hr: 243.33 s vs 55.17 s, P = 0.002) and third assessments (1 week: 226 s vs 97 s, P < 0.05) post-training, but no significant change was seen at the second (24 hr) assessment. Piperine improved the effect of a low dose of caffeine (25 mg/kg intraperitoneally after a shock of 2 s duration) in a first assessment (295.17 s vs 149.17 s, P = 0.026) compared to a higher dose of caffeine. Piperine reversed diazepam (1 mg/kg intraperitoneally) suppression of learning 24 hours after training by a 4 s shock (298 s vs 135.67 s, P = 0.03). According to the results, piperine alone significantly increased learning 1 hour and 1 week after training assessments, and learning can be improved in the short term when followed by piperine administration. It was also shown that piperine can potentiate the effect of a low dose of caffeine and can reverse the effect of diazepam.

show abstract

Using the synthesized peptide HAYED (5) to protect the brain against iron catalyzed radical attack in a naturally senescence Kunming mouse model

Zou

Cai

Zhong

et al. 2019

Free Radical Biology and Medicine

View full text Add to dashboard Cite

RETRACTED: Enhancement of learning and memory by a medicinal formulation, Saenhyetang, in mice

Cited by 6 publications

References 21 publications

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

Maintenance of superior learning and memory function in NR2B transgenic mice during ageing

Effect of breastfeeding piperine on the learning of offspring mice: interaction with caffeine and diazepam

Using the synthesized peptide HAYED (5) to protect the brain against iron catalyzed radical attack in a naturally senescence Kunming mouse model

Contact Info

Product

Resources

About