RETRACTED: Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter

Lü, Yan; Hou, Kaiqing; Li, Mengsen; Wu, Xiaobin; Yuan, Shaochun

doi:10.3389/fcell.2020.571297

Cited by 23 publications

(12 citation statements)

References 58 publications

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“…Subsequently, Wang and colleagues reported that GC tissue-derived mesenchymal stem cells (GC-MSCs) transferred miR-221 via exosomes to HGC-27 cells, promoting the proliferation and migration of HGC-27 cells [52]. In addition, exosomes carrying lncHEIH released by GC cells promote the malignant transformation of normal gastric cells [53]. Thereafter, the interaction between exosomal ncRNAs and GC attracted increasing attention among researchers.…”

Section: Exosomal Ncrnas and Gcmentioning

confidence: 99%

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

et al. 2021

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Exosomes are a subpopulation of the tumour microenvironment (TME) that transmit various biological molecules to promote intercellular communication. Exosomes are derived from nearly all types of cells and exist in all body fluids. Noncoding RNAs (ncRNAs) are among the most abundant contents in exosomes, and some ncRNAs with biological functions are specifically packaged into exosomes. Recent studies have revealed that exosome-derived ncRNAs play crucial roles in the tumorigenesis, progression and drug resistance of gastric cancer (GC). In addition, regulating the expression levels of exosomal ncRNAs can promote or suppress GC progression. Moreover, the membrane structures of exosomes protect ncRNAs from degradation by enzymes and other chemical substances, significantly increasing the stability of exosomal ncRNAs. Specific hallmarks within exosomes that can be used for exosome identification, and specific contents can be used to determine their origin. Therefore, exosomal ncRNAs are suitable for use as diagnostic and prognostic biomarkers or therapeutic targets. Regulating the biogenesis of exosomes and the expression levels of exosomal ncRNAs may represent a new way to block or eradicate GC. In this review, we summarized the origins and characteristics of exosomes and analysed the association between exosomal ncRNAs and GC development.

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Section: Exosomal Ncrnas and Gcmentioning

confidence: 99%

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

et al. 2021

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“…The next ChIP assay results indicated that MYLK-AS1 deficiency weakened the binding ability of EZH2 to LATS2 promoter (Figure 5C). Extensive reports have confirmed that EZH2 can be the main modulator in GC [29,30]; therefore, we utilized EZH2 shRNA to knockdown EZH2. Results manifested that EZH2 mRNA and protein expressions were both significantly reduced with the transfection of sh-EZH2 (Figure 5D), suggesting the successful transfection efficiency of sh-EZH2 in GC cells.…”

Section: Mylk-as1 Recruited Ezh2 To Inhibit Lats2 Transcriptionmentioning

confidence: 99%

LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer

Luo

Xiang

2021

Bioengineered

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Extensive studies showed the vital function of long noncoding RNAs (lncRNAs) in the pathological and physiological progression of tumors. Previous evidence has indicated that lncRNA MYLK Antisense RNA 1 (MYLK-AS1) acts as an oncogene to facilitate the progression of several tumors. Nevertheless, little is known about its biological role in gastric cancer (GC). Our report intended to probe the underlying mechanism and function of MYLK-AS1 in GC. Results revealed that MYLK-AS1 showed an upregulated level in GC. It was worth mentioning that upregulated MYLK-AS1 caused the unfavorable clinical outcome in GC patients. Functional assays indicated that MYLK-AS1 silencing retarded the proliferation, cell cycle, migration, and invasion in GC. Besides, in vivo assay validated that MYLK-AS1 deficiency also restrained tumor growth. Through in-depth mechanism exploration, MYLK-AS1 was uncovered to bind with wnhancer of zeste homolog 2 (EZH2), an epigenetic inhibitor, to inhibit the level of Large Tumor Suppressor 2 (LATS2), thereby exerting carcinogenicity. Conclusively, our research highlighted the importance of MYLK-AS1 in GC, indicating that MYLK-AS1 might be an effective biomarker for GC.

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“…19 LncHEIH encapsulated in exosomes was released by GC cells and then absorbed by normal gastric cells. 20 The uptake of lncHEIH leads to the up regulation of EZH2 and promotes the malignant transformation of normal gastric cells. Shi et al confirmed that cancer-associated fibroblast-derived exosomes played important roles in promoting the proliferation, migration and invasion of GC cells by delivering circ_0088300 to GC cells.…”

Section: Exosomes Mediated the Occurrence And Development Of Gcmentioning

confidence: 99%

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

Lü¹,

Fang²,

Zhang³

et al. 2021

CMAR

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Gastric cancer (GC) is a common malignant tumor affecting human health, with occult onset and poor prognosis. Exosomes are extracellular vesicles secreted by almost all cells, which can reflect the state of source cells or tissues. It is reported that exosomes are involved in almost all processes of GC. Exosomes provided a window to understand changes in cell or tissue states by carrying active components such as circular RNAs (circRNAs). CircRNAs are a naturally occurring class of endogenous noncoding RNAs and abnormal expression during the occurrence and development of GC. Exosomal circRNAs are those circRNAs stably existing in exosomes and having high clinical values as novel potential diagnosis and prognosis biomarkers of GC, which have the characteristics of abnormal expression, tissue specificity and development stage specificity. Herein, we briefly summarize the functions and roles and the current research progress of exosomes and exosomal circRNAs in GC with a focus on the potential application for GC progression, diagnosis and prognosis. We also prospected the clinical application of exosomes and exosomal circRNAs in the future.

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RETRACTED: Exosome-Delivered LncHEIH Promotes Gastric Cancer Progression by Upregulating EZH2 and Stimulating Methylation of the GSDME Promoter

Cited by 23 publications

References 58 publications

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

Exosome-derived noncoding RNAs in gastric cancer: functions and clinical applications

LncRNA MYLK-AS1 acts as an oncogene by epigenetically silencing large tumor suppressor 2 (LATS2) in gastric cancer

Exosomes and Exosomal circRNAs: The Rising Stars in the Progression, Diagnosis and Prognosis of Gastric Cancer

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