[Retracted] Expression of miR‐210, miR‐137, and miR‐153 in Patients with Acute Cerebral Infarction

Abstract

Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P < 0.05 ). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P < 0.05 ). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.

Acupuncture-Moxibustion Combined with Rehabilitation Training Is Conducive to Improving the Curative Effect, Cognitive Function, and Daily Activities of Patients with Cerebral Infarction

“…Cerebral infarction (CI) is the most common type of cerebrovascular disease, with the main clinical pathogenic factors including cerebral thrombosis, lacunar infarction, and cerebral embolism [ 2 ]. According to epidemiological data, the number of patients with CI has reached 33 million worldwide and may increase to 77 million by 2030 [ 3 ]. The pathogenesis of CI is related to the imbalance of cerebral blood supply leading to ischemic necrosis or encephalomalacia, which further causes neuron damage and brain dysfunction [ 4 ].…”

MicroRNA Expression Profile in Acute Ischemic Stroke

“…Across these studies, a recurrent nding is the elevation of miR-210 expression within brain tissue following cerebral ischemia, including ischemic stroke and hypoxic-ischemic encephalopathy (40)(41)(42)(43)(44)(45)(46). In contrast, circulating levels of miR-210 in ischemic stroke patients appear to be suppressed when compared to those of healthy controls (41,42,47,48). This same trend is observed in patients with symptomatic carotid stenosis, where miR-210 is downregulated in carotid brous cap tissue (48).…”

“…Zeng et al reported that patients with favorable recovery showed higher miR-210 expression than those with adverse outcomes ( 42 ). On the contrary, Tian et al reported that patients with lower miR-210 expression levels had increased one-year mortality, with miR-210 levels emerging as a robust predictor of mortality (AUC = 0.786) ( 47 ). While the current body of research presents variability, likely attributable to insufficient control of confounding variables across different studies, the aggregated evidence nonetheless points to miR-210 as a potentially valuable marker for predicting neurological outcomes in acute ischemic stroke scenarios.…”

Dysregulation of Serum miR-138-5p and Its Clinical Significance in Patients with Acute Cerebral Infarction

“…miRNA plays an important role in the pathophysiological regulation of cardiovascular diseases and is associated with cerebral ischemia-reperfusion injury and neuronal apoptosis [6,7]. Recently, some brain-specific miRNAs have been identified, and the differential serum levels may be promising indicators for the occurrence and prognosis of ACI, such as miR-409-3p, miR-210, and miR-137 [8,9]. miR-138-5p has been reported to be a protective factor and is involved in a variety of cell damage mechanisms under hypoxia, such as myocardial cell and retinal endothelial cell [10][11][12].…”