RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia<sup>™</sup> Platinum System

Li, Wenhui; Wang, Xianwen; Wang, Xiehong; Wang, Fenfen; Du, Zhengming; Fu, Fangshu; Wu, Wenlong; Wang, Shuya; Mu, Ziqing; Chen, Chun-Wei; Hu, Xiaomin; Ding, Jiuyang; Meng, Yunle; Qiu, Pingming; Fan, Haoliang

doi:10.1002/mgg3.1462

Cited by 13 publications

(7 citation statements)

References 171 publications

(150 reference statements)

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“…S23, Supplementary Material online), in agreement with the time of linguistic divergence. Moreover, both previous studies ( He et al 2020 ; Li et al 2020 ) and our observations based on the f 3 tests indicated that HNL was an isolated population with low gene flow compared with other mainland Bai-Yue populations. The f 4 tests of our study also illustrated that, compared with the mainland Bai-Yue populations, HNL show closer genetic connections with ancient southern East Asian ancestry and Austronesian-related ancestry, which may also be preserved by the early migration to Hainan Island.…”

Section: Discussionsupporting

confidence: 76%

“…These studies suggest that HNL manifested a close genetic relationship with indigenous populations in South China, where the Bai-Yue ancestors were believed to be widely distributed, while also retaining a unique genetic background. However, previous studies of the HNL have focused on forensic characteristics or uniparental genetic markers ( Li, Li, Ou, et al 2008 ; Peng et al 2011 ; Li et al 2013 ; Fan et al 2018 ; Song et al 2019 ; Li et al 2020 ; Mengge et al 2020 ) and have therefore failed to portray the full picture of genetic history and adaptive evolution of HNL. In addition, due to the limited amount of genetic material, small sample size, and analytical approaches, conclusions drawn from previous studies are contradictory and may show bias concerning the fine-scale population history of HNL.…”

Section: Introductionmentioning

confidence: 99%

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Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Chen

Lin

Lü

et al. 2022

Molecular Biology and Evolution

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As the most prevalent aboriginal group on Hainan Island located between South China and the mainland of Southeast Asia, the Li people are believed to preserve some unique genetic information due to their isolated circumstances, although this has been largely uninvestigated. We performed the first whole-genome sequencing of 55 Hainan Li (HNL) individuals with high coverage (∼30–50×) to gain insight into their genetic history and potential adaptations. We identified the ancestry enriched in HNL (∼85%) is well-preserved in present-day Tai-Kadai speakers residing in South China and North Vietnam, i.e., Bai-Yue populations. A lack of admixture signature due to the geographical restriction exacerbated the bottleneck in the present-day HNL. The genetic divergence among Bai-Yue populations began ∼4,000–3,000 years ago when the proto-HNL underwent migration and the settling of Hainan Island. Finally, we identified signatures of positive selection in the HNL, some outstanding examples included FADS1 and FADS2 related to a diet rich in polyunsaturated fatty acids. In addition, we observed that malaria-driven selection had occurred in the HNL, with population-specific variants of malaria-related genes (e.g., CR1) present. Interestingly, HNL harbors a high prevalence of malaria leveraged gene variants related to hematopoietic function (e.g., CD3G) that may explain the high incidence of blood disorders such as B cell lymphomas in the present-day HNL. The results have advanced our understanding of the genetic history of the Bai-Yue populations and have provided new insights into the adaptive scenarios of the Li people.

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Section: Discussionsupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Chen

Lin

Lü

et al. 2022

Molecular Biology and Evolution

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“…The 44 A-InDels of UAIS possessed relatively reasonable genetic information (PIC > 0.25) ( Botstein et al, 1980 ), and the UAIS with the CMP range of 1.27 × 10 –18 to 1.03 × 10 –14 for 27 universal human populations satisfied the requirements for forensic human identification (10 –15 –10 –14 ) ( Pereira et al, 2009 ), which indicated that the UAIS could be considered as a powerful tool for human identification. Compared with the CPE provided by the common STR panels ( Fan et al, 2019a ; Fan et al, 2019b ; Li et al, 2020 ), CPE for UAIS has outclassed 0.993634–0.999908. Therefore, the UAIS could supply additional information for the paternity tests.…”

Section: Resultsmentioning

confidence: 90%

Systematic Evaluation of a Novel 6-dye Direct and Multiplex PCR-CE-Based InDel Typing System for Forensic Purposes

Fan

et al. 2022

Front. Genet.

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Insertion/deletion (InDel) polymorphisms, combined desirable characteristics of both short tandem repeats (STRs) and single nucleotide polymorphisms (SNPs), are considerable potential in the fields of forensic practices and population genetics. However, most commercial InDel kits designed based on non-Asians limited extensive forensic applications in East Asian (EAS) populations. Recently, a novel 6-dye direct and multiplex PCR-CE-based typing system was designed on the basis of genome-wide EAS population data, which could amplify 60 molecular genetic markers, consisting of 57 autosomal InDels (A-InDels), 2 Y-chromosomal InDels (Y-InDels), and Amelogenin in a single PCR reaction and detect by capillary electrophoresis, simultaneously. In the present study, the DNA profiles of 279 unrelated individuals from the Hainan Li group were generated by the novel typing system. In addition, we collected two A-InDel sets to evaluate the forensic performances of the novel system in the 1,000 Genomes Project (1KG) populations and Hainan Li group. For the Universal A-InDel set (UAIS, containing 44 A-InDels) the cumulative power of discrimination (CPD) ranged from 1–1.03 × 10–14 to 1–1.27 × 10–18, and the cumulative power of exclusion (CPE) varied from 0.993634 to 0.999908 in the 1KG populations. For the East Asia-based A-InDel set (EAIS, containing 57 A-InDels) the CPD spanned from 1–1.32 × 10–23 to 1–9.42 × 10–24, and the CPE ranged from 0.999965 to 0.999997. In the Hainan Li group, the average heterozygote (He) was 0.4666 (0.2366–0.5448), and the polymorphism information content (PIC) spanned from 0.2116 to 0.3750 (mean PIC: 0.3563 ± 0.0291). In total, the CPD and CPE of 57 A-InDels were 1–1.32 × 10–23 and 0.999965, respectively. Consequently, the novel 6-dye direct and multiplex PCR-CE-based typing system could be considered as the reliable and robust tool for human identification and intercontinental population differentiation, and supplied additional information for kinship analysis in the 1KG populations and Hainan Li group.

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“…To obtain a broader picture of population relationships within Southeast Asia, we included publicly available STR frequency from relevant populations [ 15 , 21 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 ] and a neighbor-joining tree (NJ) based on F st computation by allele frequency from 13 STRs of the FBI Laboratory’s Combined DNA Index System (CODIS) was carried out using POPTREE v.2 [ 58 ].…”

Section: Methodsmentioning

confidence: 99%

Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand

Mawan

Prakhun

Muisuk

et al. 2021

Genes

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The hill tribes of northern Thailand comprise nine officially recognized groups: the Austroasiatic-speaking (AA) Khmu, Htin and Lawa; the Hmong-Mien-speaking (HM) IuMien and Hmong; and the Sino-Tibetan-speaking (ST) Akha, Karen, Lahu and Lisu. Except the Lawa, the rest of the hill tribes migrated into their present habitats only very recently. The Thai hill tribes were of much interest to research groups focusing on study of cultural and genetic variation because of their unique languages and cultures. So far, there have been several genetic studies of the Thai hill tribes. However, complete forensic microsatellite database of the Thai hill tribes is still lacking. To construct such database, we newly generated 654 genotypes of 15 microsatellites commonly used in forensic investigation that belong to all the nine hill tribes and also non-hill tribe highlanders from northern Thailand. We also combined 329 genotypes from previous studies of northern Thai populations bringing to a total of 983 genotypes, which were then subjected to genetic structure and population relationships analyses. Our overall results indicated homogenous genetic structure within the HM- and Tai-Kadai (TK)-speaking groups, large genetic divergence of the HM-speaking Hmong but not IuMien from the other Thai groups, and genetic heterogeneity within the ST- and AA-speaking groups, reflecting different population interactions and admixtures. In addition to establishing genetic relationships within and among these populations, our finding, which provides a more complete picture of the forensic microsatellite database of the multiple Thai highland dwellers, would not only serve to expand and strengthen forensic investigation in Thailand, but would also benefit its neighboring countries of Laos and Myanmar, from which many of the Thai hill tribes originated and where large populations of these ethnic groups still reside.

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RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 13 publications

References 171 publications

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Systematic Evaluation of a Novel 6-dye Direct and Multiplex PCR-CE-Based InDel Typing System for Forensic Purposes

Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand

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RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia™ Platinum System

Abstract: This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.

Cited by 13 publications

References 171 publications

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Tracing Bai-Yue Ancestry in Aboriginal Li People on Hainan Island

Systematic Evaluation of a Novel 6-dye Direct and Multiplex PCR-CE-Based InDel Typing System for Forensic Purposes

Autosomal Microsatellite Investigation Reveals Multiple Genetic Components of the Highlanders from Thailand

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Product

Resources

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RETRACTED: Forensic characteristics and phylogenetic analyses of one branch of Tai‐Kadai language‐speaking Hainan Hlai (Ha Hlai) via 23 autosomal STRs included in the Huaxia^™ Platinum System