RETRACTED: Hepatocellular carcinoma cells-derived exosomal microRNA-378b enhances hepatocellular carcinoma angiogenesis

Chen, Wei; Huang, Li; Liang, Junhua; Ye, Yingjian; He, Shan; Niu, Junli

doi:10.1016/j.lfs.2021.119184

Cited by 23 publications

(11 citation statements)

References 39 publications

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“…Whereas hypoxia in normal cells leads to cell death, hypoxia in tumor cells can induce specific exosomes release to adapt to the unfavorable microenvironment (Figure 3). For example, exosomal miR-155, miR-378b, and circCMTM3 derived from HCC cells promote angiogenesis in human umbilical vein endothelial cells under hypoxic conditions [55][56][57]. Interestingly, HCCderived exosomal miR-3682-3p as a negative regulator of angiopoietin-1 inhibited endothelial cells resulting in angiogenesis impairment; consequently, tumor cells downregulated its expression [58].…”

Section: Exosomal Mirna Is Involved In Regulating Thementioning

confidence: 99%

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Chen

Chi

Zhao

et al. 2022

Journal of Oncology

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Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Since most patients with HCC are diagnosed at the intermediate or advanced stage and because HCC has a high incidence of metastasis and recurrence, it is one of the leading causes of cancer death. Exosomes are a subtype of extracellular vesicles and are typically 30–150 nm in diameter. Originating from endosomes, they can be secreted by almost all living cells. They are widely present in various body fluids and serve as an important medium for the interactions between cells. A series of studies have revealed that exosomes-mediated intercellular transfer of proteins, nucleic acids, and metabolites plays a crucial role in the initiation and progression of HCC, hypoxia and angiogenesis, chemotherapy sensitivity, and cell death mode and regulates the immune microenvironment. In this paper, we reviewed the recent researches on the multiple roles of tumor-associated exosomes in the progression of HCC. We laid particular focus on those researches that reveal how exosomes regulate the tumor immune microenvironment (TIME) and how exosomal cargos affect the progression of HCC. Besides, we emphasize some prospective directions to achieve a more accurate and complete analysis of the HCC immune microenvironment.

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Section: Exosomal Mirna Is Involved In Regulating Thementioning

confidence: 99%

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Chen

Chi

Zhao

et al. 2022

Journal of Oncology

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“…Wang et al reported that elevated exosomal miR-1290 levels were found in the sera of patients with HCC, and miR-1290 promoted tumor angiogenesis by targeting SMEK1 [ 80 ]. In another study, miRNA-210 was delivered to endothelial cells, where it directly inhibited SMAD4 and STAT6 expression to enhance angiogenesis [ 81 ], while miRNA-378b promoted angiogenesis and HCC progression by targeting transforming growth factor β receptor III (TGFBR3) [ 82 ]. In addition to autonomously secreting miRNAs, HCC cells can also derive related exosomal miRNAs to affect angiogenesis, if they are affected by TAMs.…”

Section: Functions Of Exosomal Mirnas In Hccmentioning

confidence: 99%

Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma

Zhang

Liu

et al. 2022

Current Oncology

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Exosomes, extracellular vesicles with a diameter of 40 to 160 nm, are among the smallest extracellular vesicles released by cells. They deliver different cargoes, including proteins, DNAs, and RNAs, and facilitate communication between cells to coordinate a variety of physiological and pathological functions. Hepatocellular carcinoma (HCC) is the sixth common malignant tumor and the fourth leading cause of cancer-related death worldwide. Its molecular mechanism remains largely unknown, and there is a lack of reliable and noninvasive biomarkers for early diagnosis and prognosis prediction. Mounting evidence has shown that exosomes carry a variety of ncRNAs, such as long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and circular RNAs (circRNAs), which play critical roles in the occurrence and progression of HCC. In this review, we summarize the recent findings of exosomal miRNAs, lncRNAs, and circRNAs in HCC from their impact on the development of HCC to their potential applications in the diagnosis and treatment of HCC.

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“…Exosomal miR-210 could promote proliferation, migration and tube formation of endothelial cells in HCC cells via targeting SMAD4 and STAT6 in endothelial cells, which are critical for angiogenesis ( 71 ). In addition, high levels of exosomal miR-378b facilitates the angiogenesis and progression of HCC cells, which may target and negatively associated with TGFBR3, offering therapeutic strategies for HCC treatment ( 72 ). On the contrary, in the serum exosomes of patients with liver cancer, the expression of miR-451a was remarkably reduced and low level of miR-451a was associated with later clinical stages and high T classification.…”

Section: Mirnamentioning

confidence: 99%

The Potential Roles of Exosomal Non-Coding RNAs in Hepatocellular Carcinoma

et al. 2022

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Hepatocellular carcinoma (HCC) is the sixth highest-incidence cancer and the 4th most deadly cancer all over the world, with a high fatality and low diagnostic rate. Nowadays, Excessive alcohol consumption, type-2 diabetes, smoking and obesity have become some primary risk factors of HCC. As intercellular messenger transporting information cargoes between cells, exosomes are a type of extracellular vesicles (EVs) released by most types of cells including tumor cells and non-tumor cells and play a pivotal role in establishing an HCC microenvironment. Exosomes, and more generally EVs, contain different molecules, including messenger RNAs (mRNAs), non-coding RNAs (ncRNAs), proteins, lipids and transcription factors. The three main ncRNAs in exosomes are microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs). NcRNAs, identified as essential components, are selectively sorted into exosomes and exosomal ncRNAs show great potential in regulating tumor development, including proliferation, invasion, angiogenesis, metastasis, immune escape and drug resistance. Here, we chiefly review the formation and uptake of exosomes, classification of exosomal ncRNAs and current research on the roles of exosomal ncRNAs in HCC progression. We also explored their clinical applications as new diagnostic biomarkers and therapeutic avenues in HCC.

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RETRACTED: Hepatocellular carcinoma cells-derived exosomal microRNA-378b enhances hepatocellular carcinoma angiogenesis

Cited by 23 publications

References 39 publications

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Role of Exosomes in Immune Microenvironment of Hepatocellular Carcinoma

Exosomal Non-Coding RNAs: New Insights into the Biology of Hepatocellular Carcinoma

The Potential Roles of Exosomal Non-Coding RNAs in Hepatocellular Carcinoma

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