Retracted: High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex

International, BioMed Research

doi:10.1155/2017/7640820

Cited by 2 publications

(3 citation statements)

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“…wrote to numerous journal editors to express their concerns about the similarities between and errors within these and other papers. As a result, 17 publications 37–40,48–60 have been retracted, including 14 of the 48 publications originally described. 37–40,48–57 Four other publications have been corrected, 61–64 and 5 Expressions of Concern have been published, 65–69 with other journal investigations still ongoing.…”

Section: Introductionmentioning

confidence: 99%

“…For example, a co-ordinated submission approach could ensure that most manuscripts constructed around a common gene are submitted to different journals. 37–41,52,59–62,64 Simultaneous construction and then submission of highly related manuscripts to different journals could also prevent unusual similarities from being detected during the peer review process.…”

Section: Introductionmentioning

confidence: 99%

“…These individuals may be best placed to notice unusual manuscript or publication series, either through their exposure to large numbers of submitted manuscripts or through their detailed knowledge of the literature in their specific fields. Strategies to raise awareness could include publications describing the hallmarks of single-gene knockdown papers, further published research, the investigation of more individual papers by different journals and publishers, and the publication of Expressions of Concern 65–69 and retractions, 37–40,48–60 where appropriate. Awareness of the possibility of systematic research fraud could also be raised among peer reviewers by adding specific questions to manuscript review checklists.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions

et al. 2019

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A major reason for biomarker failure is the selection of candidate biomarkers based on inaccurate or incorrect published results. Incorrect research results leading to the selection of unproductive biomarker candidates are largely considered to stem from unintentional research errors. The additional possibility that biomarker research may be actively misdirected by research fraud has been given comparatively little consideration. This review discusses what we believe to be a new threat to biomarker research, namely, the possible systematic production of fraudulent gene knockdown studies that target under-studied human genes. We describe how fraudulent papers may be produced in series by paper mills using what we have described as a ‘theme and variations’ model, which could also be considered a form of salami slicing. We describe features of these single-gene knockdown publications that may allow them to evade detection by journal editors, peer reviewers, and readers. We then propose a number of approaches to facilitate their detection, including improved awareness of the features of publications constructed in series, broader requirements to post submitted manuscripts to preprint servers, and the use of semi-automated literature screening tools. These approaches may collectively improve the detection of fraudulent studies that might otherwise impede future biomarker research.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions

et al. 2019

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Semi-automated fact-checking of nucleotide sequence reagents in biomedical research publications: The Seek & Blastn tool

et al. 2019

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Nucleotide sequence reagents are verifiable experimental reagents in biomedical publications, because their sequence identities can be independently verified and compared with associated text descriptors. We have previously reported that incorrectly identified nucleotide sequence reagents are characteristic of highly similar human gene knockdown studies, some of which have been retracted from the literature on account of possible research fraud. Because of the throughput limitations of manual verification of nucleotide sequences, we developed a semi-automated fact checking tool, Seek & Blastn, to verify the targeting or non-targeting status of published nucleotide sequence reagents. From previously described and unknown corpora of 48 and 155 publications, respectively, Seek & Blastn correctly extracted 304/342 (88.9%) and 1066/1522 (70.0%) nucleotide sequences and a predicted targeting/ non-targeting status. Seek & Blastn correctly predicted the targeting/ non-targeting status of 293/304 (96.4%) and 988/1066 (92.7%) of the correctly extracted nucleotide sequences. A total of 38/39 (97.4%) or 31/79 (39.2%) Seek & Blastn predictions of incorrect nucleotide sequence reagent use were correct in the two literature corpora. Combined Seek & Blastn and manual analyses identified a list of 91 misidentified nucleotide sequence reagents, which could be built upon through future studies. In summary, incorrect nucleotide sequence reagents represent an under-recognized source of error within the biomedical literature, and fact checking tools such as Seek & Blastn may help to identify papers and manuscripts affected by these errors.

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Retracted: High Expression of PTGR1 Promotes NSCLC Cell Growth via Positive Regulation of Cyclin-Dependent Protein Kinase Complex

Cited by 2 publications

References 5 publications

The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions

The Possibility of Systematic Research Fraud Targeting Under-Studied Human Genes: Causes, Consequences, and Potential Solutions

Semi-automated fact-checking of nucleotide sequence reagents in biomedical research publications: The Seek & Blastn tool

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