RETRACTED: Identification of gene ontologies linked to prefrontal–hippocampal functional coupling in the human brain

Abstract

Significance This study combines neuroimaging and whole-genome genotyping techniques with a gene set enrichment analysis to unravel the genetic basis of a well-validated intermediate phenotype for schizophrenia, dorsolateral prefrontal cortex–hippocampal connectivity. We found significant enrichment of genes with roles in synaptic plasticity and neurodevelopment that are consistent with the neurobiological basis of prefrontal–hippocampal interactions in schizophrenia. We further provide additional independent evidence for the intermediate phenotype concept and present a readily generalizable approach for a biologically driven analysis of imaging and genetic data.

Biomarkers of postoperative delirium and cognitive dysfunction

“…Copeptin is correlated with severity of the illness and is presumed to be a prognostic measure of outcome prediction in acute illness (Katan and Christ-Crain, 2010 ). Postoperative plasma copeptin level can be an independent predictor of POD and POCD after coronary artery bypass graft surgery (Dixson et al, 2014 ). This study observed higher levels of postoperative copeptin in POD and POCD patients compared to controls.…”

Molecular genetic aetiology of general cognitive function is enriched in evolutionarily conserved regions

“…Other methods suffer from limitations such as requiring access to participants' genotypes, 17 and other methods fail to account for linkage disequilibrium (LD) that can lead to the same SNP being counted multiple times within a single gene set. 18 Here, we make use of a recently developed method, stratified linkage disequilibrium score regression, 19 that requires access to only genome-wide association summary level data. This method utilizes information from each SNP in a functional category while explicitly modelling LD to show whether a category is associated with a greater proportion of the heritability of a trait than the proportion of SNPs it contains would suggest.…”

The Emerging Neurobiology of Bipolar Disorder

“…Involvement of VGCC genes has also been reported in large-scale genomic studies of BD-relevant phenotypes, such as working memory performance and the associated patterns of brain activation [36] , as well as in general cognitive functioning [37] . There are also smaller candidate gene studies that suggest effects of CACNA1C genetic variation on brain imaging phenotypes 38 , 39 and on cognitive domains, such as reward responsiveness [40] .…”