RETRACTED: In osteoclasts, dynamic microtubules and their associated protein EB1 control podosomes and bone resorption through cortactin

Biosse-Duplan, M.; Stephens, Sebastien Robert; Lai, Frank P. L.; Oelkers, M.; Rottner, Klemens; Horne, William C.; Baron, Roland

doi:10.1016/j.bone.2011.03.141

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Switching Off Resorption1

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2011

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“…associated with the 'C' ends of microtubules and regulates stabilisation of microtubules (Biosse-Duplan et al 2011). The exact signals that halt resorption by an individual osteoclast in order for it to move to another location are not known.…”

Section: Switching Off Resorptionmentioning

confidence: 99%

The skeleton: a multi-functional complex organ. The role of key signalling pathways in osteoclast differentiation and in bone resorption

Mellis¹,

Itzstein²,

Helfrich³

et al. 2011

Journal of Endocrinology

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Osteoclasts are the specialised cells that resorb bone matrix and are important both for the growth and shaping of bones throughout development as well as during the process of bone remodelling that occurs throughout life to maintain a healthy skeleton. Osteoclast formation, function and survival are tightly regulated by a network of signalling pathways, many of which have been identified through the study of rare monogenic diseases, knockout mouse models and animal strains carrying naturally occurring mutations in key molecules. In this review, we describe the processes of osteoclast formation, activation and function and discuss the major transcription factors and signalling pathways (including those that control the cytoskeletal rearrangements) that are important at each stage.

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Section: Switching Off Resorptionmentioning

confidence: 99%