RETRACTED: Intra-articular Injections With Either Triamcinolone Hexacetonide, Stanozolol, Hylan G-F 20, or a Platelet Concentrate Improve Clinical Signs in Police Working Dogs With Bilateral Hip Osteoarthritis

Alves, J. C.; Santos, Ana; Jorge, Patrícia; Lavrador, Catarina; Carreira, L. Miguel

doi:10.3389/fvets.2020.609889

Cited by 16 publications

(25 citation statements)

References 92 publications

(28 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Detailed information on the effect of each treatment is reported elsewhere. 29 The platelet concentrate produced with Correlations for weight-bearing distribution for each limb at the moment of the initial evaluation is presented in Table 2. During the follow-up period, no significant differences were found regarding SI and deviation comparing animals with the different weight cut-off values by breed, sex, or OFA hip grade.…”

Section: Resultsmentioning

confidence: 99%

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

Topics in Companion Animal Medicine

Self Cite

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

Topics in Companion Animal Medicine

Self Cite

View full text Add to dashboard Cite

“…39 For the remaining CMIs, we set as an outcome a return to or drop below the initial values of CMI scores, as it was the point that motivated the need for medical assistance. 37,38 Further studies should aim to determine specific outcome measures.…”

Section: Discussionmentioning

confidence: 99%

“…This particular outcome was selected as it was the point that motivated the need for medical assistance. 37,38 With the CBPI, a specific measure of success has been defined, set as a reduction of ≥ 1 in PSS and ≥ 2 in PIS. 39 For that reason, for these scores, the Kaplan-Meier test was used to evaluate the score's time to drop below these measures of success levels.…”

Section: Methodsmentioning

confidence: 99%

A randomized double-blinded controlled trial on the effects of photobiomodulation therapy in dogs with osteoarthritis

Alves

Santos²,

Jorge³

et al. 2022

ajvr

Self Cite

View full text Add to dashboard Cite

OBJECTIVE To evaluate photobiomodulation therapy in dogs with bilateral hip osteoarthritis. ANIMALS 20 dogs. PROCEDURES Forty joints were assigned to a control group (CG; n = 20) or treatment group (photobiomodulation therapy [PBMT]; 20). CG received a 21-day course of meloxicam, and PBMT received treatment with a Class IV therapeutic laser over 3 weeks. Joint range of motion, thigh girth, the Canine Brief Pain Inventory (divided into pain interference score [PIS] and pain severity score [PSS]), Hudson Visual Analogue Scale, Liverpool Osteoarthritis in Dogs, and Canine Orthopedic Index (COI; divided into function, gait, stiffness, and quality of life) were evaluated before treatment, +8, +15, +30, +60, and +90 days after initial treatment. Results were analyzed with repeated measures ANOVA or Wilcoxon signed ranks test, P < 0.05. Kaplan-Meier estimators were compared with the Breslow test. RESULTS Patients had a mean age of 8.3 ± 1.9 years and body weight of 65.7 ± 12.1lb. Osteoarthritis was classified as moderate (n = 26) and severe (14). No differences were found at time 0. Better results were observed in PBMT at +8 days (P = 0.01 for PSS, P = 0.04 for function and COI), +15 days (P = 0.01 for PSS and function, P = 0.02 for PIS and function, P = 0.03 for COI and P = 0.04 for Liverpool Osteoarthritis in Dogs [LOAD]) and +30 days (P = 0.01 for function and gait, P = 0.02 for COI, and P = 0.04 for PIS, PSS, and LOAD). Joint range of motion improved in PBMT from +15 to 90 days. Kaplan-Meier estimators showed that PBMT produced longer periods with better results. CLINICAL RELEVANCE PBMT reduced pain levels and improved clinical findings in dogs with hip osteoarthritis.

show abstract

“…This finding stresses the relevance of early intervention, as it leads to a better outcome. Also, the effects of PRP are expressed by interacting with the different types of joint's cells and tissues, and in the case of severe hip OA, where significant changes have already occurred, these cells and tissues may not be as responsive or even may not be present in enough number for a more significative response to be observed [36]. Female dogs showed a lower probability to have their overall COI scores return to the initial value.…”

Section: Discussionmentioning

confidence: 99%

Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis

Alves

Santos²,

Jorge³

2021

BMC Vet Res

View full text Add to dashboard Cite

Background Osteoarthritis (OA) is the most commonly diagnosed joint disease in companion animals, and hip OA is commonly diagnosed in the canine population. The use of platelet-rich plasma has gained increasing interest for the treatment of musculoskeletal conditions in companion animals. To evaluate the effect of the intra-articular administration of platelet-rich plasma in police working dogs with bilateral hip OA compared to a control group, twenty dogs were assigned to a control group (CG, n = 10) or treatment group (PG, n = 10), using the statistical analysis software. PG received two intra-articular administrations of platelet-rich plasma, 14 days apart, while CG received an intra-articular administration of saline, in the same moments. Response to treatment was determined with the Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index, and Hudson Visual Analogue Scale, before treatment, + 8, + 15, + 30, + 60, + 90, + 120, 150, and + 180 days after initial treatment. Kaplan-Meier estimators were conducted and compared with the log-rank test. Cox proportional hazard regression analysis was performed to determine treatment survival, p < 0.05. Results The sample comprised 20 animals of both sexes (male n = 12, female n = 8), with a mean age of 8.4 ± 2.4 years and a bodyweight of 31.5 ± 5.7 kg. Joints were classified as moderate (13) and severe (7) according to the Orthopedic Foundation for Animals grading scheme. No differences were found between groups at the initial evaluation. Better results with the majority of scores were observed in the PG, in some cases lasting up to the last evaluation moment. Kaplan-Meier estimators showed that PG produced longer periods with better results in all scores compared to CG. Treatment was the covariate influencing all scores in the Cox regression analysis. OFA hip score also influenced two dimensions of the Canine Orthopedic Index. Conclusion The intra-articular administration of platelet-rich plasma can improve pain and functional scores of police working dogs with bilateral hip OA, compared with a control group. Its effects lasted for significantly longer periods, and treatment was the main covariate affecting the improvements observed.

show abstract

RETRACTED: Intra-articular Injections With Either Triamcinolone Hexacetonide, Stanozolol, Hylan G-F 20, or a Platelet Concentrate Improve Clinical Signs in Police Working Dogs With Bilateral Hip Osteoarthritis

Cited by 16 publications

References 92 publications

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

Characterization of Weight-bearing Compensation in Dogs With Bilateral Hip Osteoarthritis

A randomized double-blinded controlled trial on the effects of photobiomodulation therapy in dogs with osteoarthritis

Platelet-rich plasma therapy in dogs with bilateral hip osteoarthritis

Contact Info

Product

Resources

About