RETRACTED: Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells

Dakhly, Dina M.R.; Bayoumi, Yasser; Sharkawy, Mohamed El; Allah, Sherine H. Gad; Hassan, Muhammed A.; Gouda, Hisham M.; Hashem, Ahmed T.; Hatem, Dina; Ahmed, Mona F.; El-Khayat, Waleed

doi:10.1016/j.ijgo.2016.06.026

Cited by 59 publications

(76 citation statements)

References 21 publications

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“…For the 85 remaining articles, the full texts were examined carefully on the bases of both inclusion and exclusion criteria, and 36 studies were excluded due to unavailable data, lack of intervention group, or small sample size. Finally, results from 49 literatures were selected for further analysis . The process is displayed in a flowchart in Figure .…”

Section: Resultsmentioning

confidence: 99%

A comparison of effectiveness among frequent treatments of recurrent spontaneous abortion: A Bayesian network meta‐analysis

2018

American J Rep Immunol

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Section: Resultsmentioning

confidence: 99%

A comparison of effectiveness among frequent treatments of recurrent spontaneous abortion: A Bayesian network meta‐analysis

2018

American J Rep Immunol

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“…NK cells can simultaneously mediate cellular and humoral immunity. In addition to high expression on the surface of fetal trophoblast cells, HLA-Cw is also expressed on the surface of T and B cells (16). In conclusion, CD4 + CD25 + Treg and KIR-2DL1 may serve as new targets for the early intervention of URSA.…”

Section: Discussionmentioning

confidence: 99%

Correlation between unexplained recurrent spontaneous abortion with CD4+CD25+ regulatory T-cell and killer cell immunoglobulin-like receptor levels

Quan

Yang

2017

Experimental and Therapeutic Medicine

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The present study investigated the correlation between unexplained recurrent spontaneous abortion (URSA) with CD4+CD25+ regulatory T-cell (Treg) and killer cell immunoglobulin-like receptor (KIR)-2DL1 levels. A total of 76 URSA patients were enrolled (35 without pregnancy, Group A, and 41 with early abortion, Group B). Additionally, 30 patients who received a regular abortion as planned (Group C) and 30 healthy volunteers (Group D) were selected. Peripheral venous blood and fresh decidual tissue samples were obtained from all the patients, and flow cytometry was performed to detect CD4+CD25+Treg and Foxp3 transcription factor levels. mRNA and protein KIR-2DL1 expression levels were assayed using quantitative PCR and western blot analysis, respectively. No statistically significant differences in peripheral venous blood CD4+CD25+Treg/CD4+ and Foxp3+/CD4+CD25+Treg cell proportions were found among the groups (P>0.05). However, the decidual tissues of Group C presented significantly higher levels of both cell types versus other groups (P<0.05). No statistically significant differences were found in comparisons among Groups A, B, and D (P>0.05). In peripheral venous blood, mRNA and protein KIR-2DL1 expression levels in Group C were significantly higher than those in the other three groups (P<0.05), but again, there were no statistically significant differences among Groups A, B, and D (P>0.05). In decidual tissues, KIR-2DL1 levels were significantly higher in Group C relative to Groups A, B, and D (P<0.05). Decreased CD4+CD25+Treg counts and KIR-2DL1 expression levels were closely associated with the onset of URSA. CD4+CD25+Tregs mainly exert their effects on decidual tissues, while KIR-2DL1 can act on peripheral venous blood and decidual tissues. These may present new targets for early intervention in URSA.

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“…Many have recommended the need for larger randomized controlled trials to prove the efficacy of intralipid before it can be recommended for routine use. In 2016, Dakhly et al demonstrated that Intralipid administration did not increase the frequency of chemical pregnancy (15). However, they recommended that findings related to ongoing pregnancy and live birth should be investigated further (15).…”

Section: Discussionmentioning

confidence: 99%

“…In 2016, Dakhly et al demonstrated that Intralipid administration did not increase the frequency of chemical pregnancy (15). However, they recommended that findings related to ongoing pregnancy and live birth should be investigated further (15). They also defined the use of intralipid as a valuable therapy and advised that its use should be based solely on randomized controlled trial (16).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Fat Emulsion Intralipid 20% in Reproductive Outcome for Patients With Multiple Implantation Failure

Al-Zebeidi¹,

Lary²,

Al‐Jaroudi³

2017

International Journal of Women’s Health and Reproduction Scienc

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RETRACTED: Intralipid supplementation in women with recurrent spontaneous abortion and elevated levels of natural killer cells

Abstract: Intralipid supplementation did not increase frequency of chemical pregnancy. However, findings related to ongoing pregnancy and live birth should be investigated further. ClinicalTrials.gov:NCT01788540.

Cited by 59 publications

References 21 publications

A comparison of effectiveness among frequent treatments of recurrent spontaneous abortion: A Bayesian network meta‐analysis

A comparison of effectiveness among frequent treatments of recurrent spontaneous abortion: A Bayesian network meta‐analysis

Correlation between unexplained recurrent spontaneous abortion with CD4+CD25+ regulatory T-cell and killer cell immunoglobulin-like receptor levels

The Effect of Fat Emulsion Intralipid 20% in Reproductive Outcome for Patients With Multiple Implantation Failure

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