Retracted:Matrix metalloproteinase-1 expression inhibitory compound from the whole plants ofViola ibukiana Makino

Moon, Hyung‐In; Kim, Miran; Cho, Moon Kyun; Park, Soojie; Chung, Jin

doi:10.1002/ptr.1682

Cited by 4 publications

(1 citation statement)

References 17 publications

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“…87 Triterpenoid saponins 3-O-[O-beta-d-glucopyranosyl-(1→2)-O-beta-d-glucopyranosyl] oleanolic acid from the whole plants of Viola ibukiana Makino showed MMP-1 expression inhibition activities in a dose-dependent manner. 88 Two plant MMPs purified from soybean (Glycine max) leaves 89 and buckwheat (Fagopyrum esculentum) seeds 90 have been characterized. Evidence indicated that GmMMP2 may play a role in a novel defense mechanism in plants against pathogenic infections.…”

Section: Mmps In Plantsmentioning

confidence: 99%

Matrix metalloproteinases – an overview

Sekhon¹

2010

RRB

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Matrix metalloproteinases (MMPs, matrixins) are a family of secreted and membrane-bound zinc-dependent endopeptidases that have the combined capacity to degrade all the components of the extracellular matrix. These enzymes have a common zinc-binding motif (HEXXHXXGXXH) in their active site and a conserved methionine turn following the active site. MMP enzymes are strongly involved in a kaleidoscope of normal, pathological, physiological, and biological processes such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. MMPs play a significant role in vascular remodeling. Broad-spectrum metalloproteinase inhibitors as potential therapeutics have been developed to explore the involvement of MMPs in various diseases.

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Section: Mmps In Plantsmentioning

confidence: 99%

Matrix metalloproteinases – an overview

Sekhon¹

2010

RRB

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Naturally Occurring Triterpenoid Saponins

Dinda

Debnath²,

Mohanta

et al. 2010

Chemistry & Biodiversity

140

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Naturally occurring new triterpenoid saponins reported from mid-1996 to March, 2007 are reviewed including their physical constants and plant sources, and are compiled in Table 1. New saponins are arranged in Table 1 on the basis of the skeletal structures of their aglycones, e.g., oleanane type, ursane type, lupane type, hopane type, taraxastane type, cycloartane type, lanostane type, tirucallane type, dammarane type, cucurbitane type, and holostane type. The known triterpenoid saponins and prosapogenins of the new saponins, the biological and pharmacological activities of which were published during 1996-2007, are also reviewed together with their plant sources listed in Table 2 according to the skeletal structures of their aglycones in the same fashion as in Table 1. The plant and animal sources of both new and known bioactive triterpenoid saponins are collected in Table 3 in alphabetical order. The biological and pharmacological activities such as antiallergic, antiatherosclerosis and antiplatelet, antibacterial, anticomplementary, antidiabetic, contraceptive, antifungal, anti-inflammatory, antileishmanial, antimalarial/antiplasmodial, anti-obesity, anti-proliferative, antipsoriatic, antispasmodic, antisweet, antiviral, cytotoxic/antitumor, detoxication, gastroprotective, haemolytic, hepatoprotective, immunomodulatory, anti-enzyme, anti-osteoporotic, insecticidal, insulin-like, membrane-porosity, molluscicidal, neuropharmacological, anti-endothelial dysfunction, snake venom antidote, and sweet activities of these saponins or derived prosapogenins are discussed briefly after Table 3.

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