RETRACTED: Melatonin attenuates inflammation and promotes regeneration in rabbits with fulminant hepatitis of viral origin

Laliena, Almudena; Miguel, Beatriz San; Crespo, Irene; Álvarez, María Asunción Aneas; González‐Gallego, Javier; Tuñón, María J.

doi:10.1111/j.1600-079x.2012.00995.x

Cited by 71 publications

(66 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Therefore, ER stress inhibition could be used as a possible therapeutic strategy to reduce apoptotic cell death in FHF. In an animal model of FHF of viral origin induced by infection with the rabbit hemorrhagic disease virus (RHDV) , melatonin inhibited apoptosis in a dose‐dependent manner and enhanced liver regeneration .…”

Section: Melatonin and Liver Diseasesmentioning

confidence: 99%

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Fernández

Ordóñez

Reíter

et al. 2015

Journal of Pineal Research

434

301

View full text Add to dashboard Cite

Endoplasmic reticulum (ER) is a dynamic organelle that participates in a number of cellular functions by controlling lipid metabolism, calcium stores, and proteostasis. Under stressful situations, the ER environment is compromised, and protein maturation is impaired; this causes misfolded proteins to accumulate and a characteristic stress response named unfolded protein response (UPR). UPR protects cells from stress and contributes to cellular homeostasis re-establishment; however, during prolonged ER stress, UPR activation promotes cell death. ER stressors can modulate autophagy which in turn, depending of the situation, induces cell survival or death. Interactions of different autophagy-and apoptosis-related proteins and also common signaling pathways have been found, suggesting an interplay between these cellular processes, although their dynamic features are still unknown. A number of pathologies including metabolic, neurodegenerative and cardiovascular diseases, cancer, inflammation, and viral infections are associated with ER stress, leading to a growing interest in targeting components of the UPR as a therapeutic strategy. Melatonin has a variety of antioxidant, anti-inflammatory, and antitumor effects. As such, it modulates apoptosis and autophagy in cancer cells, neurodegeneration and the development of liver diseases as well as other pathologies. Here, we review the effects of melatonin on the main ER stress mechanisms, focusing on its ability to regulate the autophagic and apoptotic processes. As the number of studies that have analyzed ER stress modulation by this indole remains limited, further research is necessary for a better understanding of the crosstalk between ER stress, autophagy, and apoptosis and to clearly delineate the mechanisms by which melatonin modulates these responses.

show abstract

Section: Melatonin and Liver Diseasesmentioning

confidence: 99%

Melatonin and endoplasmic reticulum stress: relation to autophagy and apoptosis

Fernández

Ordóñez

Reíter

et al. 2015

Journal of Pineal Research

434

301

View full text Add to dashboard Cite

show abstract

“…Additionally, melatonin reduced phosphorylated Janus kinase expression and enhanced extracellular mitogen-activated protein kinase (ERK) and signal transducer and activator of transcription (STAT) 3 expression. It has been shown that melatonin had an anti-inflammation effect and stimulated regenerative mechanisms in rabbits infected by RHDV [138]. Concomitantly, hepatocyte apoptosis was crucial in the progress of fulminant hepatitis infected by RHDV.…”

Section: Protective Effects Of Melatonin On Hepatitismentioning

confidence: 99%

Effects of Melatonin on Liver Injuries and Diseases

Zhang

Meng

et al. 2017

IJMS

103

View full text Add to dashboard Cite

Liver injuries and diseases are serious health problems worldwide. Various factors, such as chemical pollutants, drugs, and alcohol, could induce liver injuries. Liver diseases involve a wide range of liver pathologies, including hepatic steatosis, fatty liver, hepatitis, fibrosis, cirrhosis, and hepatocarcinoma. Despite all the studies performed up to now, therapy choices for liver injuries and diseases are very few. Therefore, the search for a new treatment that could safely and effectively block or reverse liver injuries and diseases remains a priority. Melatonin is a well-known natural antioxidant, and has many bioactivities. There are numerous studies investigating the effects of melatonin on liver injuries and diseases, and melatonin could regulate various molecular pathways, such as inflammation, proliferation, apoptosis, metastasis, and autophagy in different pathophysiological situations. Melatonin could be used for preventing and treating liver injuries and diseases. Herein, we conduct a review summarizing the potential roles of melatonin in liver injuries and diseases, paying special attention to the mechanisms of action.

show abstract

“…Silymarin (200mg/Kg/day) (Li et al 2012) cholorogenic acid (60 mg/Kg/day) ( Shi et Al. 2009) and melatonin (20 mg/Kg/day) (Laliena et al 2012) were suspended in gum acacia (2% w/v) and given orally once daily for 21 successive days, 24h post CCl 4 injection. After the experimental period, blood samples were collected from each animal in all groups into sterilized tubes for serum separation.…”

Section: Animals and Treatmentsmentioning

confidence: 99%