RETRACTED: MicroRNA-34 suppresses proliferation of human ovarian cancer cells by triggering autophagy and apoptosis and inhibits cell invasion by targeting Notch 1

Jia, Yan; Lin, Rui-Qing; Jin, Haixia; Si, Lihui; Jian, Wenwen; Yu, Qing; Yang, Shijie

doi:10.1016/j.biochi.2019.03.011

Cited by 45 publications

(22 citation statements)

References 27 publications

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“…Ovarian cancer is one of the prevalent cancers in perimenopausal women. The notch is highly expressed in the neural precursor cells and plays a critical role in regulating neural differentiation and neural proliferation . Overexpression of miR‐34 inhibits the proliferation of ovarian cancer cells by inducing apoptosis and autophagy via targeting of Notch receptor 1 (Notch 1) .…”

Section: Introductionmentioning

confidence: 99%

“…The notch is highly expressed in the neural precursor cells and plays a critical role in regulating neural differentiation and neural proliferation. 95,96 Overexpression of miR-34 inhibits the proliferation of ovarian cancer cells by inducing apoptosis and autophagy via targeting of Notch receptor 1 (Notch 1). 97 AlkB homolog 5 (ALKBH5) is an N6-methyladenosine (m6A) eraser protein.…”

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confidence: 99%

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MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

et al. 2019

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Autophagy is a highly conserved catabolic process and fundamental biological process in eukaryotic cells. It recycles intracellular components to provide nutrients during starvation and maintains quality control of organelles and proteins. In addition, autophagy is a well‐organized homeostatic cellular process that is responsible for the removal of damaged organelles and intracellular pathogens. Moreover, it also modulates the innate and adaptive immune systems. Micro ribonucleic acids (microRNAs) are a mature class of post‐transcriptional modulators that are widely expressed in tissues and organs. And, it can suppress gene expression by targeting messenger RNAs for translational repression or, at a lesser extent, degradation. Research indicates that microRNAs regulate autophagy through different pathways, playing an essential role in the treatment of various diseases. It is an important regulator of fundamental cellular processes such as proliferation, autophagy, and cell apoptosis. In this review article, we first review the current knowledge of autophagy and the function of microRNAs. Then, we summarize the mechanism of autophagy and the signaling pathways related to autophagy by citing at least the main proteins involved in the different phases of the process. Second, we introduce other members of RNA and report some examples in various pathologies. Finally, we review the current literature regarding microRNA‐based therapies for cancer, atherosclerosis, cardiac disease, tuberculosis, and viral diseases. MicroRNAs can cause autophagy upregulation or downregulation by targeting genes or affecting autophagy‐related signaling pathways. Therefore, the microRNAs have a huge potential in autophagy regulation, and it is the function as diagnostic and prognostic markers.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

et al. 2019

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“…Due to effective detection in body fluids, high stability, and tissue-specific expression patterns, miRNAs have potential as novel biomarkers. MiR-34 induces the autophagy and apoptosis of tumor cells, regulates tumor proliferation, and targets notch-1, thereby inhibiting cell invasion in OC [ 41 ]. Serum miR-375 and miR-1307 are upregulated in OC and may be used to support diagnosis in combination with CA-125 [ 42 ].…”

Section: Application Of Epigenetics In Ocmentioning

confidence: 99%

Ovarian cancer: epigenetics, drug resistance, and progression

Xie

Sun

et al. 2021

Cancer Cell Int

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Ovarian cancer (OC) is one of the most common malignant tumors in women. OC is associated with the activation of oncogenes, the inactivation of tumor suppressor genes, and the activation of abnormal cell signaling pathways. Moreover, epigenetic processes have been found to play an important role in OC tumorigenesis. Epigenetic processes do not change DNA sequences but regulate gene expression through DNA methylation, histone modification, and non-coding RNA. This review comprehensively considers the importance of epigenetics in OC, with a focus on microRNA and long non-coding RNA. These types of RNA are promising molecular markers and therapeutic targets that may support precision medicine in OC. DNA methylation inhibitors and histone deacetylase inhibitors may be useful for such targeting, with a possible novel approach combining these two therapies. Currently, the clinical application of such epigenetic approaches is limited by multiple obstacles, including the heterogeneity of OC, insufficient sample sizes in reported studies, and non-optimized methods for detecting potential tumor markers. Nonetheless, the application of epigenetic approaches to OC patient diagnosis, treatment, and prognosis is a promising area for future clinical investigation.

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“…For instance, low expression of miR-29b and, consequently, high expression of its target ATG9, has been associated with ovarian cancer relapse [96] . In ovarian cancer, miR-34 is expressed at low levels, while its over-expression suppressed the NOTCH signaling pathway resulting in upregulation of autophagy and induction of apoptosis thus limiting cancer aggressiveness [97] . At variance, in cervical cancer, high levels of miR-34C-5p down-regulated autophagy, thus improving the chemotherapy response, by targeting ATG4B [98] .…”

Section: Non-coding Rnas Regulation Of Autophagy In Cancers Affectingmentioning

confidence: 99%

Epigenetic control of autophagy in women’s tumors: role of non-coding RNAs

Vidoni¹,

Vallino²,

Ferraresi³

et al. 2021

JCMT

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RETRACTED: MicroRNA-34 suppresses proliferation of human ovarian cancer cells by triggering autophagy and apoptosis and inhibits cell invasion by targeting Notch 1

Cited by 45 publications

References 27 publications

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

MicroRNAs play an essential role in autophagy regulation in various disease phenotypes

Ovarian cancer: epigenetics, drug resistance, and progression

Epigenetic control of autophagy in women’s tumors: role of non-coding RNAs

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