[Retracted] MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in vitro

Ji, Chenxing; Fan, Yanghua; Xu, Fan; Lv, Shigang; Ye, Min-Hua; Wu, Miao-Jing; Zhu, Xingen; Wu, Lei

doi:10.3892/or.2020.7785

Cited by 2 publications

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“…Evidence suggests that miRNAs have a role in glioma formation, and that genetically modified MSC can slow the growth of glioma tumors [62]. The regulatory functions of miRNAs have a significant role in GBM by affecting cell proliferation [63], progression [64][65][66], apoptosis [67], drug resistance [68], and metastasis [69]. It can limit tumor progression by restoring the expression of these miRNAs, indicating a new strategy to tumor therapy [70,71].…”

Section: Micrornamentioning

confidence: 99%

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

et al. 2022

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Brain tumors are one of the most mortal cancers, leading to many deaths among kids and adults. Surgery, chemotherapy, and radiotherapy are available options for brain tumor treatment. However, these methods are not able to eradicate cancer cells. The blood–brain barrier (BBB) is one of the most important barriers to treat brain tumors that prevents adequate drug delivery to brain tissue. The connection between different brain parts is heterogeneous and causes many challenges in treatment. Mesenchymal stem cells (MSCs) migrate to brain tumor cells and have anti-tumor effects by delivering cytotoxic compounds. They contain very high regenerative properties, as well as support the immune system. MSCs-based therapy involves cell replacement and releases various vesicles, including exosomes. Exosomes receive more attention due to their excellent stability, less immunogenicity and toxicity compare to cells. Exosomes derived from MSCs can develop a powerful therapeutic strategy for different diseases and be a hopeful candidate for cell-based and cell-free regenerative medicine. These nanoparticles contain nucleic acid, proteins, lipids, microRNAs, and other biologically active substances. Many studies show that each microRNA can prevent angiogenesis, migration, and metastasis in glioblastoma. These exosomes can—act as a suitable nanoparticle carrier for therapeutic applications of brain tumors by passing through the BBB. In this review, we discuss potential applications of MSC and their produced exosomes in the treatment of brain tumors.

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Section: Micrornamentioning

confidence: 99%

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

et al. 2022

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An Integrated Data Analysis of mRNA, miRNA and Signaling Pathways in Pancreatic Cancer

et al. 2021

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[Retracted] MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in vitro

Abstract: MicroRNA-375 inhibits glioma cell proliferation and migration by downregulating RWDD3 in vitro chen-XIng JI, yang-hua Fan, Fan Xu, shI-gang lv, MIn-hua ye, MIao-JIng Wu, XIn-gen Zhu and leI Wu This work is licensed under a Creative Commons Attribution 4.0 International (CC BY 4.0) License.

Cited by 2 publications

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Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

Mesenchymal stem cell-derived exosomes as a new therapeutic strategy in the brain tumors

An Integrated Data Analysis of mRNA, miRNA and Signaling Pathways in Pancreatic Cancer

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