Retracted: Misoprostol versus expectant management in women with incomplete first‐trimester miscarriage after failed primary misoprostol treatment: A randomized clinical trial

Abstract

Objective To compare the effectiveness and safety of repeat misoprostol versus expectant management in women with first‐trimester incomplete miscarriage who have been initially treated with misoprostol. Methods The study was an open‐labeled randomized controlled trial including women with an incomplete first‐trimester miscarriage after administration of misoprostol. The participants were randomly assigned to vaginal misoprostol or expectant management using a computer‐generated table of random numbers. The primary outcome was the number of women with a complete miscarriage at 1 week. Results Eighty‐eight women (44 women in each group) were analyzed. The rate of complete miscarriage at 1 week was significantly higher in the misoprostol group than the expectant management group—29 (69.0%) versus 7 (16.7%) (P < 0.001), respectively. Women in the misoprostol group were more satisfied (7.00 ± 0.77 vs 4.57 ± 1.61, P < 0.001) but reported more pain (7.95 ± 1.85 vs 5.26 ± 1.08, P < 0.001) than women in the expectant group. The misoprostol group reported more adverse effects than the expectant management group (P < 0.001). Conclusion In women with an incomplete first‐trimester miscarriage who were initially treated with misoprostol, repeat administration of misoprostol was more effective than expectant management for achieving complete miscarriage at 1 week. However, misoprostol was associated with more adverse effects. Registration site and number Clinicaltrials.gov: NCT03148561.

Medical treatment of miscarriage using Misoprostol - a retrospective study

“…The history of one or more cesarean sections led to signi cantly more failure in medical treatment (p = 0.001). This is con rmed by a recent RCT from 2021 [23] stating that history of cesarean sections lead to more failure in treatment. Correspondingly a recent study from 2022 [24] examined predictive parameters to failure in treatment with Misoprostol in women with one or more cesarean sections in the past.…”

Predictor assessment of complete miscarriage after medical treatment for early pregnancy loss in women with previous cesarean section

“…[ 15 ] A recent study suggested that a previous cesarean section (odds ratio [OR]: 5.15, 95% confidence interval [CI]: 1.15–23.05, P = .032) was a significant predictor for incomplete miscarriage. [ 16 ] Nevertheless, clinical factors that could be predictive of successful medical treatment for EPL within the specific study population who had previous cesarean deliveries were not investigated.…”