RETRACTED: Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis

Mohamed, Nagwa I; Suddеk, Ghada M.; El‐Kashef, Dalia H.

doi:10.1016/j.intimp.2021.108005

Cited by 8 publications

(3 citation statements)

References 60 publications

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“…High concentrations of ROS attack and inactivate endogenous antioxidant factors, such as GSH, SOD, and CAT, thus preventing their effective neutralization of ROS. In the present study, the GSH, SOD, and CAT activities of colon tissue were significantly reduced in DSS-treated mice ( Figure 2 G), which is consistent with previous reports [ 44 , 45 ]. Notably, MAS administration significantly inhibited the elevation of colonic MDA activity and restored colonic GSH, SOD, and CAT activities.…”

Section: Discussionsupporting

confidence: 93%

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

Zhang

et al. 2022

Antioxidants

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Mulberry has attracted wide attention due to its substantial nutritional values. This work first studied the protective effect of mulberry anthocyanins (MAS) on dextran sulfate sodium (DSS)-induced colitis. The mice experiment was designed as four groups including normal mice (Control), dextran sodium sulfate (DSS)-fed mice, and DSS plus 100 mg/kg·bw MAS-fed mice (LMAS-DSS) or DSS plus 200 mg/kg·bw MAS-fed mice (HMAS-DSS). Mice were given MAS by gavage for 1 week, and then DSS was added to the drinking water for 7 days. MAS was administered for a total of 17 days. The results showed that oral gavage of MAS reduced the disease activity index (DAI), prevented colon shortening, attenuated colon tissue damage and inflammatory response, suppressed colonic oxidative stress and restored the protein expression of intestinal tight junction (TJ) protein (ZO-1, occludin and claudin-3) in mice with DSS-induced colitis. In addition, analysis of 16S rRNA amplicon sequences showed that MAS reduced the DSS-induced intestinal microbiota dysbiosis, including a reduction in Escherichia-Shigella, an increase in Akkermansia, Muribaculaceae and Allobaculum. Collectively, MAS alleviates DSS-induced colitis by maintaining the intestinal barrier, modulating inflammatory cytokines, and improving the microbial community.

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Section: Discussionsupporting

confidence: 93%

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

Zhang

et al. 2022

Antioxidants

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“…It is hypothesized that DN intake may modulate gastrointestinal flora metabolism and promote local redox-reduction interactions, thereby exerting beneficial effects on gastrointestinal flora and health status. Dysregulated NO metabolism is associated with ulcerative colitis (UC) [ 94 ]. NO can kill bacteria and regulate gastrointestinal mucosal blood flow (MBF) and mucus production, thus protecting the GT.…”

Section: Relationship Between Nrb and Their Metabolic Process And Hos...mentioning

confidence: 99%

From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease

Liu,

Huang,

Huang

et al. 2023

Eur J Med Res

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Current research has described improving multisystem disease and organ function through dietary nitrate (DN) supplementation. They have provided some evidence that these floras with nitrate (NO3−) reductase are mediators of the underlying mechanism. Symbiotic bacteria with nitrate reductase activity (NRA) are found in the human digestive tract, including the mouth, esophagus and gastrointestinal tract (GT). Nitrate in food can be converted to nitrite under the tongue or in the stomach by these symbiotic bacteria. Then, nitrite is transformed to nitric oxide (NO) by non-enzymatic synthesis. NO is currently recognized as a potent bioactive agent with biological activities, such as vasodilation, regulation of cardiomyocyte function, neurotransmission, suppression of platelet agglutination, and prevention of vascular smooth muscle cell proliferation. NO also can be produced through the conventional l-arginine–NO synthase (l-NOS) pathway, whereas endogenous NO production by l-arginine is inhibited under hypoxia–ischemia or disease conditions. In contrast, exogenous NO3−/NO2−/NO activity is enhanced and becomes a practical supplemental pathway for NO in the body, playing an essential role in various physiological activities. Moreover, many diseases (such as metabolic or geriatric diseases) are primarily associated with disorders of endogenous NO synthesis, and NO generation from the exogenous NO3−/NO2−/NO route can partially alleviate the disease progression. The imbalance of NO in the body may be one of the potential mechanisms of disease development. Therefore, the impact of these floras with nitrate reductase on host systemic health through exogenous NO3−/NO2−/NO pathway production of NO or direct regulation of floras ecological balance is essential (e.g., regulation of body homeostasis, amelioration of diseases, etc.). This review summarizes the bacteria with nitrate reductase in humans, emphasizing the relationship between the metabolic processes of this microflora and host systemic health and disease. The potential effects of nitrate reduction bacteria on human health and disease were also highlighted in disease models from different human systems, including digestive, cardiovascular, endocrine, nervous, respiratory, and urinary systems, providing innovative ideas for future disease diagnosis and treatment based on nitrate reduction bacteria.

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“…UC not only reduces the quality of life of patients but also increases the risk of colorectal cancer (Kim et al 2021;Linson and Hanauer 2021). The pathogenesis of UC is not yet fully elucidated, and many factors are thought to be implicated in the occurrence and development of this disease, e.g., inflammation (Mandlik et al 2021;Mohamed et al 2021;Oladele et al 2021), oxidative stress (Mandlik et al 2021;Mohamed et al 2021;Oladele et al 2021), immune dysfunction (Xue et al 2021), genetic variation (Yoganathan et al 2021), intestinal microbiota (Tong et al 2021), and apoptosis (Mohamed et al 2021). The main therapeutic drugs for UC are salicylic acids, immunosuppressants and corticosteroids, but their clinical cure rates are usually unsatisfactory, and it is easy to relapse after drug withdrawal.…”

Section: Introductionmentioning

confidence: 99%

Total Glucosides of Paeony Attenuates Ulcerative Colitis via Inhibiting TLR4/NF-<i>κ</i>B Signaling Pathway

Xiang

et al. 2022

Tohoku J. Exp. Med.

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RETRACTED: Molsidomine alleviates acetic acid-induced colitis in rats by reducing oxidative stress, inflammation and apoptosis

Cited by 8 publications

References 60 publications

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

Mulberry Anthocyanins Ameliorate DSS-Induced Ulcerative Colitis by Improving Intestinal Barrier Function and Modulating Gut Microbiota

From nitrate to NO: potential effects of nitrate-reducing bacteria on systemic health and disease

Total Glucosides of Paeony Attenuates Ulcerative Colitis via Inhibiting TLR4/NF-<i>κ</i>B Signaling Pathway

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