RETRACTED: NGF protects neuroblastoma cells against β‐amyloid‐induced apoptosis via the Nrf2/HO‐1 pathway

Abstract

As one of the main neurotrophic factors, nerve growth factor (NGF) participates in various processes related to viability, plasticity, and neuronal growth. NGF is known to protect against cell death and toxicity triggered by β‐amyloid (Aβ), but the underlying mechanism remains unclear. Here, we investigated this process in SKNSH neuroblastoma, in which NGF reduced cell death induced by Aβ25–35. Furthermore, NGF suppressed the production of reactive oxygen species (ROS) and promoted antioxidant function via Aβ25–35. Additionally, we demonstrated that NGF impaired the activation of the JNK/c‐Jun signaling pathway and significantly increased Nrf2 nuclear translocation and HO‐1 expression. Nrf2 elimination abolished the protective effect of NGF‐1 on Aβ25–35‐induced ROS generation, apoptosis, and activation of the JNK/c‐Jun pathway. The results of our study indicate that NGF protects neuroblastoma against injury triggered by Aβ25–35 via suppression of ROS–JNK/c‐Jun pathway stimulation through the Nrf2/HO‐1 pathway.

Neurotrophins as Key Regulators of Cell Metabolism: Implications for Cholesterol Homeostasis

“…NGF, BDNF and NT-4 exert neuroprotective effects by attenuating oxidative stress [ 105 ]. The antioxidant activity induced by these growth factors confers resistance to neuronal damage during neurodegenerative conditions, and is associated with the promotion of Nrf2 nuclear translocation and the subsequent heme oxygenase 1 (HO-1) upregulation [ 106 , 107 , 108 , 109 ]. The link between NTs and oxidative stress is further highlighted by the fact that drinking habits and inadequate eating regimens can disrupt NTs metabolism, possibly by affecting ROS production.…”

The mir-423-5p/MMP-2 Axis Regulates the Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis

“…NGF acts not only on the central and peripheral nervous systems but also on nonneuronal tissues and cancer cells [38]. NGF plays a multi-functional role in the tumor environment, exerting effects on tumor cell proliferation, survival, apoptosis, angiogenesis and metastasis [38,45,46]. Our study is the first to describe an association between NGF levels and the tumor stage in chondrosarcoma tissue specimens.…”

The miR-423-5p/MMP-2 Axis Regulates Nerve Growth Factor-Induced Promotion of Chondrosarcoma Metastasis

“…NGF acts not only on the central and peripheral nervous systems, but also on non-neuronal tissues and cancer cells (34). NGF plays a multi-functional role in the tumor environment, exerting effects on tumor cell proliferation, survival, apoptosis, angiogenesis and metastasis (34,41,42). Our study is the rst to describe an association between NGF levels and tumor stage in chondrosarcoma tissue specimens.…”