RETRACTED: Non-neuronal cholinergic system delays cardiac remodelling in type 1 diabetes

Munasinghe, Pujika Emani; Saw, Eng Leng; Reily-Bell, Matthew; Tonkin, Devin; Kakinuma, Yoshihiko; Fronius, Martin; Katare, Rajesh

doi:10.1016/j.heliyon.2023.e17434

Cited by 4 publications

(3 citation statements)

References 45 publications

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“…Other important up-regulated genes were Fxyd2 (FXYD domain-containing ion transport regulator 2), an important regulator of the Na + transport [ 81 ], and Itgb6 (myo-inositol 1-phosphate synthase A1), involved in resynchronization following heart failure [ 82 ]. From the identified down-regulated genes, of note are Gsk3b (glycogen synthase kinase-3β), a critical regulator of cell proliferation and differentiation [ 83 ]; Chat (choline acetyltransferase), related to the ventricular remodeling in type 1 diabetes [ 84 ]; and Cmpk2 (cytidine monophosphate), involved in inflammatory diseases [ 85 ].…”

Section: Discussionmentioning

confidence: 99%

Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Iacobas,

Allen,

Iacobas

2024

CIMB

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Low-salt diet (LSD) is a constant recommendation to hypertensive patients, but the genomic mechanisms through which it improves cardiac pathophysiology are still not fully understood. Our publicly accessible transcriptomic dataset of the left ventricle myocardium of adult male mice subjected to prolonged LSD or normal diet was analyzed from the perspective of the Genomic Fabric Paradigm. We found that LSD shifted the metabolic priorities by increasing the transcription control for fatty acids biosynthesis while decreasing it for steroid hormone biosynthesis. Moreover, LSD remodeled pathways responsible for cardiac muscle contraction (CMC), chronic Chagas (CHA), diabetic (DIA), dilated (DIL), and hypertrophic (HCM) cardiomyopathies, and their interplays with the glycolysis/glucogenesis (GLY), oxidative phosphorylation (OXP), and adrenergic signaling in cardiomyocytes (ASC). For instance, the statistically (p < 0.05) significant coupling between GLY and ASC was reduced by LSD from 13.82% to 2.91% (i.e., −4.75×), and that of ASC with HCM from 10.50% to 2.83% (−3.71×). The substantial up-regulation of the CMC, ASC, and OXP genes, and the significant weakening of the synchronization of the expression of the HCM, CHA, DIA, and DIL genes within their respective fabrics justify the benefits of the LSD recommendation.

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Section: Discussionmentioning

confidence: 99%

Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Iacobas,

Allen,

Iacobas

2024

CIMB

View full text Add to dashboard Cite

show abstract

“…Other important up-regulated genes were Fxyd2 (FXYD domain-containing ion transport regulator 2), an important regulator of the Na + transport [81], and Itgb6 (myo-inositol 1-phosphate synthase A1), involved in resynchronization following heart failure [82]. From the identified downregulated genes, of note are: Gsk3b (glycogen synthase kinase-3β), a critical regulator of cell proliferation and differentiation [83], Chat (choline acetyltransferase) related to the ventricular remodeling in type 1 diabetes [84], and Cmpk2 (cytidine monophosphate) involved in inflammatory diseases [85].…”

Section: Discussionmentioning

confidence: 99%

Low-salt Diet Regulates the Metabolic and Signal Transduc-tion Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Iacobas,

Allen,

Iacobas

2024

Preprint

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“…It can also be performed in individuals who cannot exercise. Using streptozotocin (STZ)-induced type 1 DM mice (T1DMm), Munasinghe et al revealed that under T1DM conditions, dysregulation of the NNCCS (i.e., DM induced downregulation of ChAT in the heart) and reduced ACh levels were associated with impaired cardiac function [i.e., increased left ventricular (LV) end-diastolic and -systolic volume and reduced ejection fraction and LV end-systolic pressure] ( 33 ). Increasing ACh levels in the heart of ChAT-tgm could prevent these effects.…”

Section: Nnccs and Ripc In Diabetes Mellitus (Dm)mentioning

confidence: 99%

Potential effect of the non-neuronal cardiac cholinergic system on hepatic glucose and energy metabolism

Kurabayashi,

Iwashita,

Furihata

et al. 2024

Front. Cardiovasc. Med.

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The vagus nerve belongs to the parasympathetic nervous system, which is involved in the regulation of organs throughout the body. Since the discovery of the non-neuronal cardiac cholinergic system (NNCCS), several studies have provided evidence for the positive role of acetylcholine (ACh) released from cardiomyocytes against cardiovascular diseases, such as sympathetic hyperreactivity-induced cardiac remodeling and dysfunction as well as myocardial infarction. Non-neuronal ACh released from cardiomyocytes is believed to regulate key physiological functions of the heart, such as attenuating heart rate, offsetting hypertrophic signals, maintaining action potential propagation, and modulating cardiac energy metabolism through the muscarinic ACh receptor in an auto/paracrine manner. Moreover, the NNCCS may also affect peripheral remote organs (e.g., liver) through the vagus nerve. Remote ischemic preconditioning (RIPC) and NNCCS activate the central nervous system and afferent vagus nerve. RIPC affects hepatic glucose and energy metabolism through the central nervous system and vagus nerve. In this review, we discuss the mechanisms and potential factors responsible for NNCCS in glucose and energy metabolism in the liver.

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RETRACTED: Non-neuronal cholinergic system delays cardiac remodelling in type 1 diabetes

Cited by 4 publications

References 45 publications

Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Low-Salt Diet Regulates the Metabolic and Signal Transduction Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Low-salt Diet Regulates the Metabolic and Signal Transduc-tion Genomic Fabrics, and Remodels the Cardiac Normal and Chronic Pathological Pathways

Potential effect of the non-neuronal cardiac cholinergic system on hepatic glucose and energy metabolism

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