RETRACTED: Novel Insights Into the Role of Mitochondria-Derived Peptides in Myocardial Infarction

Wu, Dan; Kampmann, Enny; Qian, Geng

doi:10.3389/fphys.2021.750177

Cited by 5 publications

(7 citation statements)

References 137 publications

(150 reference statements)

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“…Exogenously administered HNG increased cardiomyocyte survival and inhibited apoptosis. Thummasorn et al found that HNG treatment decreased cardiac arrhythmias and infarct size and improved the function of the left ventricle during MI-R [ 68 , 69 , 70 ]. The authors showed that HNG treatment enhanced cardiac mitochondrial function and decreased the mitochondrial ROS level in cardiac cells.…”

Section: Resultsmentioning

confidence: 99%

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

Biology

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Background: Senescence is a cellular aging process in all multicellular organisms. It is characterized by a decline in cellular functions and proliferation, resulting in increased cellular damage and death. These conditions play an essential role in aging and significantly contribute to the development of age-related complications. Humanin is a mitochondrial-derived peptide (MDP), encoded by mitochondrial DNA, playing a cytoprotective role to preserve mitochondrial function and cell viability under stressful and senescence conditions. For these reasons, humanin can be exploited in strategies aiming to counteract several processes involved in aging, including cardiovascular disease, neurodegeneration, and cancer. Relevance of these conditions to aging and disease: Senescence appears to be involved in the decay in organ and tissue function, it has also been related to the development of age-related diseases, such as cardiovascular conditions, cancer, and diabetes. In particular, senescent cells produce inflammatory cytokines and other pro-inflammatory molecules that can participate to the development of such diseases. Humanin, on the other hand, seems to contrast the development of such conditions, and it is also known to play a role in these diseases by promoting the death of damaged or malfunctioning cells and contributing to the inflammation often associated with them. Both senescence and humanin-related mechanisms are complex processes that have not been fully clarified yet. Further research is needed to thoroughly understand the role of such processes in aging and disease and identify potential interventions to target them in order to prevent or treat age-related conditions. Objectives: This systematic review aims to assess the potential mechanisms underlying the link connecting senescence, humanin, aging, and disease.

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Section: Resultsmentioning

confidence: 99%

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Coradduzza

Congiargiu

Chen

et al. 2023

Biology

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“…HN, a 24 amino-acid residues peptide [ 60 ], is similar in size and structure to melittin. HN counteracts the mitochondrial dysfunction in cardiac tissue by stabilizing the mitochondrial membrane potential, mitochondrial structure and ATP levels [ 61 ]—presumably through affecting the mitochondrial membrane lipid phase via an unknown mechanism [ 62 , 63 , 64 ]. Thus, it is possible to suggest that bee venom melittin evolved similarly to cobra venom CTs from endogenous cationic peptides which regulate the activities of membrane-associated proteins via the modulation of the lipid phase polymorphism of membranes.…”

Section: Discussionmentioning

confidence: 99%

Short-Chained Alcohols Make Membrane Surfaces Conducive for Melittin Action: Implication for the Physiological Role of Alcohols in Cells

Wang

Qin

Garab

et al. 2022

Cells

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Alcohols are a part of cellular metabolism, but their physiological roles are not well understood. We investigated the effects of short-chain alcohols on Daphnia pulex and model membranes mimicking the lipid composition of eukaryotic inner mitochondrial membranes. We also studied the synergistic effects of alcohols with the bee venom membrane-active peptide, melittin, which is structurally similar to endogenous membrane-active peptides. The alcohols, from ethanol to octanol, gradually decreased the heart rate and the mitochondrial ATP synthesis of daphnia; in contrast, in combination with melittin, which exerted no sizeable effect, they gradually increased both the heart rate and the ATP synthesis. Lipid packing and the order parameter of oriented films, monitored by EPR spectroscopy of the spin-labeled probe 5-doxylstrearic acid, revealed gradual alcohol-assisted bilayer to non-bilayer transitions in the presence of melittin; further, while the alcohols decreased, in combination with melittin they increased the order parameter of the film, which is attributed to the alcohol-facilitated association of melittin with the membrane. A 1H-NMR spectroscopy of the liposomes confirmed the enhanced induction of a non-bilayer lipid phase that formed around the melittin, without the permeabilization of the liposomal membrane. Our data suggest that short-chain alcohols, in combination with endogenous peptides, regulate protein functions via modulating the lipid polymorphism of membranes.

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“…MO peptides are organ-specific extracts that are aimed at revitalizing and rejuvenating mitochondrial activity, thereby regenerating cells and organisms. Unlike NOPs, MOs are larger in size and have predominantly mitochondriaspecific functions that allows for a more pronounced revitalization of mitochondrial function [11,12].…”

Section: Am J Biomed Sci and Resmentioning

confidence: 99%

Mass Spectrometry Analysis of Novel Stem Cell-Derived Peptides

Lakey

2022

AJBSR

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Short peptides have been demonstrated to play an important role in modulating transcription, the transmission of biological information, and in restoring the genetic alterations that occur with aging. This paper aims to describe a method of identifying a population of peptides derived from a peptide cocktail formulation. Samples of Nano Organo Peptides (NOP) and Mito Organelles (MO) Peptides derived from both the Central Nervous System (CNS) and the Lungs (LBS) of Specific Pathogen Free (SPF) mammalian rabbits sourced from Charles River Labs were analyzed by mass spectrometry and chromatograms were generated for further examination. The experimentally derived peaks were searched against a database of known proteins to identify the peptides present in each sample. The following report outlines the experimental methods and the results from performing mass spectrometry on various peptides from the company European Wellness (EW).

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RETRACTED: Novel Insights Into the Role of Mitochondria-Derived Peptides in Myocardial Infarction

Cited by 5 publications

References 137 publications

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Humanin and Its Pathophysiological Roles in Aging: A Systematic Review

Short-Chained Alcohols Make Membrane Surfaces Conducive for Melittin Action: Implication for the Physiological Role of Alcohols in Cells

Mass Spectrometry Analysis of Novel Stem Cell-Derived Peptides

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