RETRACTED: Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/ microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis

Han, Wei; Sulidankazha, Qiuman; Nie, Xiaohan; Reheman, Yilidan; Len, Kunzeng

doi:10.1016/j.lfs.2021.119495

Cited by 30 publications

(24 citation statements)

References 37 publications

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“…MicroRNA-138-5p is one of the important tumor suppressor regulators, and has been found in breast cancer (Xun et al, 2021), gastric cancer (Fan et al, 2021), renal cell carcinoma (Xue et al, 2021), pancreatic cancer (Han et al, 2021), and other tumors. In recent studies on breast cancer (Xun et al, 2021), it has been found that miR-138-5p mimics can be transfected to up-regulate miR-138-5p which reduced the expression of KDM6B and thus inhibited M1 polarization and promoted M2 polarization of macrophages in breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…More importantly, the down-regulation of miR-138-5p was of special significance for lymph node metastasis and local infiltration of gastric cancer. In the study of pancreatic cancer (Han et al, 2021), it was found that miR-138-5p was down-regulated in PANC-1 cells, and silencing of miR-138-5p induced the increase of CCAT1 and HMGA1 expression. CCAT1 competitively bound to miR-138-5p to regulate downstream HMGA1 expression, and ultimately affected the progression of pancreatic cancer.…”

Section: Discussionmentioning

confidence: 99%

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LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

Mei

Xian

Jin

2021

Front. Mol. Biosci.

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Infantile hemangioma (IH) is a common benign tumor of endothelial cells in infants. Most hemangiomas are self-limited, but a few may develop and lead to serious complications that affect the normal life of children. Therefore, finding an effective treatment strategy for IH is a pressing need. Recent studies have demonstrated that non-coding RNAs affect the progression of multiple tumors. This study aims to investigate the mechanism by which LncRNA-MCM3AP-AS1 promotes glycolysis in the pathogenesis of IH. We first documented that the expression of LncRNA MCM3AP-AS1 was significantly upregulated in IH. Furthermore, we demonstrated that MCM3AP-AS1 bound to miR-106b-3p which promotes glycolysis in IH. In addition, we found that inhibition of HIF-1α contributed to the transformation of glycolysis to normal aerobic oxidation, partially reversed the promoting effect on glycolysis by the up-regulation of LncRNA MCM3AP-AS1 in IH disease. More importantly, we demonstrated this phenomenon existed in IH patients. Taken together, we demonstrate that LncRNA-MCM3AP-AS1 promotes the progression of infantile hemangiomas by increasing the glycolysis via regulating miR-138-5p/HIF-1α axis.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

Mei

Xian

Jin

2021

Front. Mol. Biosci.

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“…Many studies have confirmed that exosomal lncRNAs can promote the malignant progression of tumours by promoting angiogenesis. [119][120][121] In addition, exosomal lncRNA can also mediate immunosuppressive microenvironments, 122,123 regulate cell radioresistance 124 and mediate metabolic reprogramming, 125 but there is no relevant research report in BC. In the future, more research should be done to explore the role of exosomal lncRNAs in the above aspects and the pros-…”

Section: Future Prospects Of Exosomal Lncrnas In Bcmentioning

confidence: 99%

The emerging roles of exosomal long non‐coding RNAs in bladder cancer

Liu

2022

J Cellular Molecular Medi

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Bladder cancer (BC) is one of the most common malignant tumours of the genitourinary system, accounting for the 9th most common malignant tumour in the world. 1,2 According to pathological classification, 90% of patients with BC have urothelial cancer. About one-third of these patients are first diagnosed with muscle invasive bladder cancer (MIBC). 3,4 In some patients, even if the first diagnosis is non-muscle invasive bladder cancer (NMIBC), 10%-30% of patients progress to MIBC. 4,5 BC has become a disease that seriously affects human health. 6,7 At present, its early diagnosis and treatment have made great progress, 8,9 but its specific mechanism of occurrence and development is still unclear.In recent years, non-coding RNAs (ncRNAs) have become a research hotspot. NcRNAs can be divided into housekeeping ncRNAs and regulatory ncRNAs. Among them, regulatory ncRNAs can be mainly divided into microRNA (miRNA), long noncoding RNA (ln-cRNA) and circular RNA (circRNA). [10][11][12][13] LncRNA is a general term for single-stranded nucleotide sequences exceeding 200 bp. 14 Although it does not have the function of encoding proteins, it can participate in gene regulation at the epigenetic level, transcription level and post-transcriptional level, 15-17 affect tumour occurrence, development, metastasis and malignant progression of drug resistance. [18][19][20][21][22][23] Based on the current research on the mechanism of lncRNA, the competitive endogenous 'ceRNA' mechanism is the most common type and a widely recognized regulatory mechanism, that is, some

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“…Almost a decade later, more simplified in vitro incubation of pancreatic tumor cell-derived EVs with human umbilical vein endothelial cells (HUVEC) led to observations of dynamin-dependent endocytosis of tumor-EVs and enhanced tube formation associated with the activation of Akt and ERK1/2 in ECs [ 85 ]. Similarly, the lncRNA UCA1 and CCAT1, contained in PDA tumor EVs, were shown to promote angiogenesis in hypoxic conditions through miR-96-5p regulation [ 86 ] and miR-138-5p/HMGA1 axis [ 87 ], respectively.…”

Section: Stromal Cells Evs-mediated Crosstalkmentioning

confidence: 99%

The Cellular and Biological Impact of Extracellular Vesicles in Pancreatic Cancer

Hussain

Nigri

Tomasini

2021

Cancers

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Deciphering the interactions between tumor and stromal cells is a growing field of research to improve pancreatic cancer-associated therapies and patients’ care. Indeed, while accounting for 50 to 90% of the tumor mass, many pieces of evidence reported that beyond their structural role, the non-tumoral cells composing the intra-tumoral microenvironment influence tumor cells’ proliferation, metabolism, cell death and resistance to therapies, among others. Simultaneously, tumor cells can influence non-tumoral neighboring or distant cells in order to shape a tumor-supportive and immunosuppressive environment as well as influencing the formation of metastatic niches. Among intercellular modes of communication, extracellular vesicles can simultaneously transfer the largest variety of signals and were recently reported as key effectors of cell–cell communication in pancreatic cancer, from its development to its evolution as well as its ability to resist available treatments. This review focuses on extracellular vesicles-mediated communication between different cellular components of pancreatic tumors, from the modulation of cellular activities and abilities to their biological and physiological relevance. Taking into consideration the intra-tumoral microenvironment and its extracellular-mediated crosstalk as main drivers of pancreatic cancer development should open up new therapeutic windows.

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RETRACTED: Pancreatic cancer cells-derived exosomal long non-coding RNA CCAT1/ microRNA-138-5p/HMGA1 axis promotes tumor angiogenesis

Cited by 30 publications

References 37 publications

LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

LncRNA-MCM3AP-AS1 Promotes the Progression of Infantile Hemangiomas by Increasing miR-138-5p/HIF-1α Axis-Regulated Glycolysis

The emerging roles of exosomal long non‐coding RNAs in bladder cancer

The Cellular and Biological Impact of Extracellular Vesicles in Pancreatic Cancer

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