Retracted Paper - Comparison Between Killed and Living Probiotic Usage Versus Placebo for the Prevention of Necrotizing Enterocolitis and Sepsis in Neonates

Abstract

LP and KP were preventive factors for NEC with absolute risk reduction (AAR) 16, 15%, respectively and 18% for NS compared to placebo. Incidence of NEC and NS did not differ significantly between neonates supplemented with LP and those with KP. Preterm neonates supplemented with KP showed significantly lower incidence of NEC compared to placebo, while incidence of NS showed no significant difference between both groups. There is significant reduction in NS and NEC among neonates with positive Lactobacillus colonization of gut compared to those none colonized at day 7 (27.9 vs. 85.9%, 0 vs. 7.8%) and at day 14 (48.7 vs. 91.7% for NS and 0 vs. 20.8% for NEC). Overall comparison between the three groups showed statistical significant reduction in the incidence of NEC. Present conclusions are that early gut colonization with beneficial bacteria lowers the incidence of NEC and NS. KP retained similar benefits to live bacteria.

Factors influencing gastrointestinal tract and microbiota immune interaction in preterm infants

“…Thus, preterm infants treated with inactivated probiotics showed a decreased incidence of NEC as compared to the control babies (64) Further, large clinical trials are required to answer these issues and to support and push the development of new probiotic products, which would benefit preterm population.…”

Antimicrobial Activity of some <i>Lactobacillus</i> Species against Intestinal Pathogenic Bacteria

“…quickly colonized in intestinal epithelial which they disorder growth and proliferation of enteropathogens with producing bacteriocin and lactic acid and also reducing pH [10,17,18]. And also, Lactobacillus plays a critical role in the immune system, such as local control immune responses, allergic and inflammation diseases by increasing the activity of macrophages and immunoglobulin IgA production [19][20][21]. The present study was carried out to identify, and characterize some lactic acid bacteria as potential probiotics with antibacterial activity against microorganisms that are a pathogen and the probiotic properties were investigated through in vitro assays.…”

Importancia de la microbiota gastrointestinal en pediatría

“…61 Un estudio realizado en Egipto reportó que L rhmnosus GG, o una preparación de una cepa muerta del mismo probiotico, redujo significativamente la incidencia de enterocolitis. 62 A pesar de que la Asociación Americana de Pediatría reconoce que existe evidencia de que los probióticos previenen la enterocolitis necrotizante en neonatos con muy bajo peso al nacer, hacen el llamado a realizar más estudios para aclarar la dosis efectiva y la cepa de probiótico antes de utilizarlos como una recomendación clínica. 63 Otros consideran la evidencia existente como suficiente para hacer cambios en la práctica.…”