RETRACTED: Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first <scp>ICSI</scp> cycle

Maged, Ahmed M.; Rashwan, Hamsa; Abdelaziz, Suzy; Ramadan, Wafaa; Mostafa, Walaa; Metwally, Ahmed A.; Katta, Maha

doi:10.1002/ijgo.12355

Cited by 34 publications

(100 citation statements)

References 29 publications

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“…The risk of bias of the included RCTs is described in Table II. For seven RCTs, the risk of selection bias was unclear because the method of allocation was not clearly described (Karimzadeh et al , 2009; Baum et al , 2012; Inal et al , 2012; Singh et al , 2015; Mahran et al , 2016; Liu et al , 2017; Maged et al , 2018). Random sequence generation was interpreted to be at a low risk of selection bias because this was performed by computer-generated sequence (Narvekar et al , 2010; Safdarian et al , 2011; Inal et al , 2012; Nastri et al , 2013; Yeung et al , 2014; Gibreel et al , 2015; Singh et al , 2015; Tk et al , 2017; Maged et al , 2018), a table of random numbers (Baum et al , 2012; Liu et al , 2017), sealed envelopes (Mahran et al , 2016) or a bag of papers with equal amounts of intervention and control groups (Karimzadeh et al , 2009).…”

Section: Resultsmentioning

confidence: 99%

“…Since the publication of the abovementioned reviews, multiple RCTs on endometrial injury prior to ART have been carried out. While the first trials mainly focused on patients with RIF, more recent studies have shifted their focus to also include patients in earlier stages of IVF/ICSI treatment (Mahran et al , 2016; Liu et al , 2017; Tk et al , 2017; Maged et al , 2018). The increase in number of published studies not only calls for an updated review of the existing body of evidence, but also has created the possibility to subgroup patients according to the number of failed IVF/ICSI cycles.…”

Section: Introductionmentioning

confidence: 99%

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Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis

Hoogenhuijze

Kasius²,

Broekmans

et al. 2019

Human Reproduction Open

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STUDY QUESTION What is the effect of endometrial scratching in patients with or without prior failed ART cycles on live birth (LBR) and clinical pregnancy rates (CPR)? SUMMARY ANSWER It remains unclear if endometrial scratching improves the chance of pregnancy and, if so, for whom. WHAT IS KNOWN ALREADY Endometrial scratching is hypothesized to improve embryo implantation in ART. Multiple studies have been published, but it remains unclear if endometrial scratching actually improves pregnancy rates and, if so, for which patients. STUDY DESIGN, SIZE, DURATION For this review, a systematic search for published articles on endometrial scratching and ART was performed on 12 February 2018, in Pubmed, Embase and the Cochrane Library. PARTICIPANTS/MATERIALS, SETTING, METHODS Randomized controlled trials (RCTs) that evaluated endometrial scratching in the cycle prior to the stimulation cycle and reported CPR or LBR were included. RCTs investigating the effect of scratching during the stimulation cycle, or prior to cryo-thaw cycles were excluded. Studies were assessed using the Cochrane Risk of Bias tool. The effect of scratching was assessed for three different patient groups: patients with no prior IVF/ICSI treatment (Group 0), patients with one failed full IVF/ICSI cycle, including cryo-thaw cycles (Group 1) and patients with two or more failed full IVF/ICSI cycles (Group 2). A meta-analysis was performed when statistical heterogeneity was low; otherwise, a descriptive analysis was performed. MAIN RESULTS AND THE ROLE OF CHANCE Fourteen RCTs involving 2537 participants were included. Most RCTs contained a high or unclear risk of bias on one or more items. Substantial clinical and statistical heterogeneity was present; therefore meta-analysis for LBR and CPR could only be performed on Group 1. For this group, no differences between scratch and control were found for both LBR (risk ratio (RR) 1.01 [95%CI 0.68–1.51]) and CPR (RR 1.04 [95%CI 0.74–1.45]). For Groups 0 and 2, pooled analysis could not be performed, and for both groups the results of the individual RCTs were negative, neutral and positive. Miscarriage and multiple pregnancy rates were evaluated for the three groups (0, 1 and 2) together. Both outcomes were not significantly different between scratch and control (miscarriage rate RR 0.82 [95%CI 0.57–1.17] and multiple pregnancy rate RR 1.06 [95%CI 0.84–1.35]). Subgroup analysis, excluding trials with a risk of unintentional endometrial injury in the control group, was performed for Group 0 and 2 for LBR and CPR, and for the overall groups for miscarriage rate and multiple pregnancy rate. This reduced the heterogeneity and allowed for pooled analysis in these subgroups. Results of pooled analysis for the subgroups of Group 0 and 2 showed no significant difference for LBR, but CPR was significantly improved after endometrial scratchin...

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis

Hoogenhuijze

Kasius²,

Broekmans

et al. 2019

Human Reproduction Open

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show abstract

“…Poor ovarian response was defined in accordance with the Bologna criteria as a minimum of two of the following factors: maternal age of 40 years or older or any other risk factor for poor response; a previous poor response to a conventional stimulation protocol (i.e., cancelled cycle or retrieval of three follicles or less); or an abnormal ovarian reserve test result (antral follicle count, <5-7; or anti-Müllerian hormone, ≤0.5-1.1 ng/mL). 17 The exclusion criteria were any factors that might affect repro- Serum β-hCG levels were assessed 14 days after embryo transfer.…”

Section: Methodsmentioning

confidence: 99%

Effect of body mass index on the outcome of IVF cycles among patients with poor ovarian response

Maged

Rashwan

Mahmood

et al. 2018

Intl J Gynecology & Obste

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Objective To assess the effects of body mass index (BMI) on the outcome of IVF cycles among poor responders. Methods A prospective cohort study in Egypt enrolled 185 poor responders who underwent intracytoplasmic sperm injection via an antagonist protocol between 2012 and 2017. Participants were classified into three groups by BMI (calculated as weight in kilograms divided by the square of height in meters): 18.5–24.9 (normal, n=48); 25–29.9 (overweight, n=54); 30 or higher (obese, n=83). Outcomes were clinical pregnancy rate, implantation rate, chemical pregnancy rate, gonadotropin dose, number of oocytes and embryos, and cancellation rate. Results There was no significant difference among the three groups in gonadotropin dose; duration of stimulation; endometrial thickness on trigger day; number of oocytes retrieved, injected, or fertilized; number of embryos, transferred embryos, or frozen embryos; or day of embryo transfer. Frequency of implantation (11/81 [14%] vs 6/96 [6%] or 5/155 [3%]), chemical pregnancy (20 [42%] vs 14 [30%] or 12 [14%]) and clinical pregnancy (15 [31%] vs 12 [22%] and 9 [11%]) was significantly higher for normal than for overweight or obese women, respectively. Conclusion Implantation, chemical pregnancy, and clinical pregnancy rates were inversely related to increasing BMI. ClinicalTrials.gov: NCT03457233

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“…Further exploration of this phenomenon in a larger group of patients, indeed showed for the fi rst time, that repeated endometrial biopsy substantially increased the IVF outcome in RIF patients [5]. This favorable effect of endometrial biopsy on IVF outcome, was later demonstrated by other clinical centers, most of which selected RIF patients undergoing IVF for their studies [6][7][8][9][10][11][12][13].…”

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confidence: 86%

Endometrial local injury, a simple procedure that improves IVF outcome in a selected population of patients

Granot¹,

Dekel²

2020

J Gynecol Res Obstet

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RETRACTED: Randomized controlled trial of the effect of endometrial injury on implantation and clinical pregnancy rates during the first ICSI cycle

Abstract: Endometrial injury in the cycle preceding the stimulation cycle improved implantation and pregnancy rates during ICSI. CLINICALTRIALS.GOV: NCT02660125.

Cited by 34 publications

References 29 publications

Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis

Endometrial scratching prior to IVF; does it help and for whom? A systematic review and meta-analysis

Effect of body mass index on the outcome of IVF cycles among patients with poor ovarian response

Endometrial local injury, a simple procedure that improves IVF outcome in a selected population of patients

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