Retracted: Recoveries of Post-Tetanic Twitch and Train-of-Four Responses After Administration of Vecuronium With Different Inhalation Anaesthetics and Neuroleptanaesthesia

Abstract

We have studied recovery of post-tetanic twitch (PTT) and train-of-four (TOF) responses after administration of vecuronium in 100 patients under different inhalation anaesthetics and neuroleptanaesthesia. Patients were allocated randomly to five groups of 20 patients each to receive: neuroleptanaesthesia (droperidol and fentanyl), halothane, isoflurane, enflurane or sevoflurane (1 MAC in nitrous oxide and oxygen). The times from initial administration of vecuronium 0.2 mg kg-1 to the first appearances of T1, T2, T3 and T4 differed significantly between groups. However, the intervals to the first appearance of PTT1, PTT10 and PTT20 did not differ significantly between groups.

Effect of isoflurane and sevoflurane on the magnitude and time course of neuromuscular block produced by vecuronium, pancuronium and atracurium

“…Recent studies on the effect of sevoflurane on duration of vecuronium -induced neuromuscular block yielded data that showed wide variation on the extent of prolongation [2][3][4]. However, there were several methodological differences compared with our study.…”

“…A lth o u g h sevoflurane appears to increase both in te n sity and duration of neuromuscular block in d u c e d by vecuronium and pancuronium [1][2][3][4], the m a g n itu d e of this effect has not been quantified in a hom ogeneous population. Such information is clini-procedures of an anticipated duration of ^ 90 min under general anaesthesia.…”

“…However, there were several methodological differences compared with our study. First, in these studies, patient ages ranged from 22 to 77 yr [2], 22 to 62 yr [3] and 25 to 75 yr [4], respectively. Second, offset of neuromuscular block was measured using the evoked IE M G , which was shown to be unreliable in 5-42% (18% in the current study) of patients [29].…”

“…These studies were unable to show any significant difference for the effects of 1.15% isoflurane and 1.70% sevoflurane (both with 70 % nitrous oxide [1,2]) or for the effects of 1.15% isoflurane and 2.05% sevoflurane (both with 66 % nitrous oxide [3]) on the block produced interaction study, comvecuronium. Another paring opioid-nitrous oxide-oxygen and opioid ms oxide-oxygen demonstrate anv % on the vecuronium In order to clarify the inconsistencies in the literature on the interactions between sevoflurane and neuromuscular blockers, we have compared the effect of equipotent concentrations of isoflurane and sevoflurane on non-depolarizing neuromuscular block in a carefully selected, homogeneous popu lation of young adults.…”

Neuromuscular interaction of sevoflurane — cisatracurium in a myasthenic patient

“…11 Volatile anesthetics can also potentiate the neuromuscular block of non-depolarizing muscle relaxants in a concentration-dependent manner, by acting mainly at the post junctional membrane. 1 1 A recent report has shown that sevoflurane produces time-dependent potentiation of vecuronium neuromuscular block.…”