RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

Maifata, Sadiq Mu'azu; Hod, Rafidah; Zakaria, Nor Fadhlina; Ghani, Fauzah Abd

doi:10.3390/biom10020319

Cited by 11 publications

(7 citation statements)

References 27 publications

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“…Similar to the anti-PLA2R antibody, the anti-THSD7A antibody is mostly detected in IMN; however, it cannot completely distinguish IMN from SMN. Maifata et al (30) detected the serum anti-THSD7A antibody in four patients with IMN (4/47, 8.5%) and in two patients with SMN (2/22, 9.1%). In addition, studies have shown that the anti-THSD7A antibodies levels are associated with the treatment response and disease activity (46).…”

Section: Thsd7amentioning

confidence: 99%

“…Many studies have shown that PLA2R is more common in IMN than in SMN (26)(27)(28)(29)(30)(31), suggesting that PLA2R has certain clinical value for distinguishing between the two types. However, it has also been detected in SMN (26)(27)(28)(29)(30)(31), especially in hepatitis, sarcoidosis, and tumor-related SMN. Larsen et al (31) detected PLA2R1 in 80 cases of SMN renal tissues by indirect immunofluorescence.…”

Section: Pla2rmentioning

confidence: 99%

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Novel Biomarkers in Membranous Nephropathy

Liu

Lin

et al. 2022

Front. Immunol.

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Membranous nephropathy (MN) is the main cause of adult nephrotic syndrome (NS). The pathogenesis of MN is complex and involves subepithelial immune complex deposition. Approximately one-third of patients with MN develop end-stage renal disease (ESRD). Timely diagnosis and reasonable intervention are the keys to improving prognosis. In recent years, with the development of high-throughput technologies, such as mass spectrometry (MS), microarray, and sequencing technologies, the discovery of biomarkers for MN has become an important area of research. In this review, we summarize the significant progress in biomarker identification. For example, a variety of podocyte target antigens and their autoantibodies have been reported. Phospholipase A2 receptor (PLA2R) is the most well-established target antigen in MN. PLA2R and its autoantibodies have clinical significance, with both diagnostic and therapeutic value for MN. In addition, a variety of new biomarkers, including proteins, metabolites, noncoding RNAs (ncRNAs), and immune cells, have recently been found. These MN-related biomarkers have great significance in the diagnosis, progression, prognosis, and treatment response of MN.

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Section: Thsd7amentioning

confidence: 99%

Section: Pla2rmentioning

confidence: 99%

Novel Biomarkers in Membranous Nephropathy

Liu

Lin

et al. 2022

Front. Immunol.

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“…Due to its autoimmune nature, these MN cases are defined as primary MN 1 . The identification of PLA2R and THSD7A auto‐antibodies has contributed to the understanding of MN pathogenesis and both have been used as diagnostic and prognostic biomarkers in MN 7,8 …”

Section: Figurementioning

confidence: 99%

Bioinformatic investigation for candidate genes and molecular mechanism in the pathogenesis of membranous nephropathy

Zhong

Zhang

et al. 2020

Nephrology

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Aim We aimed to explore the detailed molecular mechanism of immune‐associated genes in membranous nephropathy (MN). Methods A microarray data set (GSE133288) was retrieved from the Gene Expression Omnibus database. Differentially expressed mRNAs (DEMs) in MN vs control groups were identified, and MN‐related DEMs (MN‐DEMs) were further verified and screened using the comparative toxicogenomics database (CTD) database. The publicly available database, InnateDB was used to investigate immune genes, and the overlapped genes between MN‐DEMs and the immune genes were considered as MN‐related immune genes (iDEMs). A protein‐protein interaction network (PPI) was constructed based on these iDEMs, followed by function and pathway enrichment analysis. Finally, microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) associated with iDEMs were predicted, followed by a lncRNA‐miRNA‐mRNA (competing endogenous RNAs, ceRNA) network construction. Results A total of 327 DEMs and 48 iDEMs were revealed; a PPI network was constructed with 100 PPI pairs and 37 iDEMs. iDEMs including JUN and FOS were mainly enriched in pathways such as osteoclast differentiation and function including response to immobilization stress, respectively. Based on mRNA‐associated miRNA and lncRNA prediction, 30 ceRNA interactions including KCNQ1OT1‐miR‐204‐5p‐SRY‐Box Transcription Factor 4 (SOX4) were explored. Conclusion mRNAs including FOS and JUN might participate in MN development via response to immobilization stress function and the osteoclast differentiation pathway. The mRNA SOX4 might contribute to MN progression via sponging KCNQ1OT1‐miR‐204‐5p interaction.

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“…Nevertheless, reduction in proteinuria is related to achieving remission in primary MGN (6,7). In addition, studies were conducted on the same patients to determine the prognosis using M-type phospholipase A2 receptors (M-PLA2R) and Thrombospondin domain-containing type 7 A (THSD7A) demonstrated a direct relationship with proteinuria (8). In this study, we predict prognostic risk factors for primary MGN patients for effective intervention.…”

Section: Introductionmentioning

confidence: 99%

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

Maifata¹,

Ghani²,

Hod³

et al. 2022

Preprint

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Background: Membranous glomerulonephritis (MGN) is one of the most common causes of nephrotic syndrome in non-diabetic adults, accounting for up to one-third of biopsy diagnostics in some regions. A watchful waiting strategy has been adopted to accurately assess the success of MGN. In this study, we predict prognostic risk factors for primary MGN patients for effective intervention and prognosis. Materials and Methods: This is a retrospective study design involving 125 biopsy-proven MGN subjects on follow-up from January 2012 to October 2019 in Hospital Serdang and Hospital Kuala Lumpur, Malaysia. Result and Conclusion: After the median follow-up of 36 (15.0-57.0) months, 26 (20.8%) consisting of 17 (13.6%) primary MGN and 9 (7.2%) secondary MGN subjects achieved complete remission while 17 (13.6%) and 10 (8.0%) of primary and secondary MGN subjects respectively achieved spontaneous remission. Subjects with nephrotic range proteinuria have 2.917 odds more at risk of primary MGN while subjects with hypertension have 2.417 odds risk of primary MGN compared to those with no hypertension at presentation. Multiple logistic regression models retained only factors directly associated with MGN with only nephrotic range proteinuria associated with primary MGN. Those with nephrotic range proteinuria were 3.04 times the odds of primary MGN when compared with those without nephrotic syndrome (95% C. I = 1.089, 8.472). The nephrotic syndrome could be used to determine the prognosis in patients with primary MGN especially those at risk of end-stage kidney disease.

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RETRACTED: Role of Serum and Urine Biomarkers (PLA2R and THSD7A) in Diagnosis, Monitoring and Prognostication of Primary Membranous Glomerulonephritis

Cited by 11 publications

References 27 publications

Novel Biomarkers in Membranous Nephropathy

Novel Biomarkers in Membranous Nephropathy

Bioinformatic investigation for candidate genes and molecular mechanism in the pathogenesis of membranous nephropathy

Membranous Glomerulonephritis: A Retrospective Study on Prognostic Outcome

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