[Retracted] ROS Signaling‐Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes

Abstract

Biomolecule metabolism produces ROS (reactive oxygen species) under physiological and pathophysiological conditions. Dietary factors (alcohol) and carcinogens (EGF, DEN, and MNNG) also induce the release of ROS. ROS often causes cell stress and tissue injury, eventually resulting in disorders or diseases of the body through different signaling pathways. Normal metabolism of protein is critically important to maintain cellular function and body health. Brf1 (transcript factor II B-related factor 1) and its target genes, RNA Pol III genes (RNA polymerase III-dependent genes), control the process of protein synthesis. Studies have demonstrated that the deregulation of Brf1 and its target genes is tightly linked to cell proliferation, cell transformation, tumor development, and human cancers, while alcohol, EGF, DEN, and MNNG are able to induce the deregulation of these genes through different signaling pathways. Therefore, it is very important to emphasize the roles of these signaling events mediating the processes of Brf1 and RNA Pol III gene transcription. In the present paper, we mainly summarize our studies on signaling events which mediate the deregulation of these genes in the past dozen years. These studies indicate that Brf1 and RNA Pol III genes are novel biological targets of ROS.

The causal effect of serum micronutrients on malignant kidney neoplasm in European descent

“…The anticancer effect of zinc was mainly attributed to its antioxidant properties. Under homeostatic conditions, the body produced reactive oxygen species (ROS), which were involved in many biological processes (cell differentiation, apoptosis) ( 29 , 30 ). Due to the high metabolic demand of tumors, tumor tissues produced large amounts of ROS, which promoted tumor growth by causing DNA damage and inducing gene mutations ( 31 , 32 ).…”

“…The anticancer effect of zinc was mainly attributed to its antioxidant properties. Under homeostatic conditions, the body produced reactive oxygen species (ROS), which were involved in many biological processes (cell differentiation, apoptosis) (29,30). 1 , the total SNPs after the screen using the p-value, physical distance (kb > 10,000), and linkage disequilibrium (R 2 < 0.001); nSNP 2 , the total SNPs after the removal of incompatible, palindromic, and outlier SNPs; P (mr_presso): The P for the testing of outlier SNPs.…”

Retracted: ROS Signaling-Mediated Novel Biological Targets: Brf1 and RNA Pol III Genes

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”