[Retracted] Safety and Efficacy of Early Carotid Endarterectomy in Patients with Symptomatic Carotid Artery Stenosis: A Meta‐Analysis

Abstract

Background and Purpose. This study is aimed at assessing the differences in postoperative stroke, myocardial infarction (MI), and mortality in patients with symptomatic carotid artery stenosis (sCAS) treated with early or late carotid endarterectomy (CEA) to determine and compare the safety of different operation timing. Design. A systematic document retrieval of studies published in the past 10 years reporting periprocedural stroke/mortality/MI after carotid endarterectomy (CEA) related to the time between CEA and qualifying neurological symptoms. The application database has “PubMed, EMbase and Cochrane databases.” RevMan5.3 software provided by the Cochrane collaboration was used for meta-analysis. Results. A systematic literature search was conducted in databases. A total of 10 articles were included in this study. They were divided into early CEA and delayed CEA with operation within 48 h, 1 w, or 2 w after onset of neurological symptoms. Incidence of the postoperative stroke in patients undergoing delayed CEA (≥48 h) was significantly higher than patients with delayed CEA (<48 h) ( OR = 2.14 , 95% CI: 1.43-3.21, P = 0.0002 ). The postoperative mortality of patients after delayed CEA (≥48 h) was significantly higher than patients after early CEA (<48 h) ( OR = 1.35 , 95% CI: 1.06-1.71, P = 0.02 ). The risk of postoperative mortality of patients treated with delayed CEA (≥7 d) was significantly higher than patients after the early CEA group (<7 d) ( OR = 1.69 , 95% CI: 1.21-2.32, P = 0.001 ). Conclusion. Early CEA is safe and effective for a part of patients with symptomatic carotid stenosis, but a comprehensive preoperative evaluation of patients with carotid stenosis must be performed.

Endarterectomía vs injerto endovascular en pacientes con estenosis de la arteria carótida interna

“…La seguridad del procedimiento y las tasas de complicaciones perioperatorias son también de suma importancia en la toma de decisiones terapéuticas. Chen et al (51) encontraron que una CEA retrasada se asoció con un aumento en la incidencia de accidente cerebrovascular posoperatorio, lo que pone de relieve la crítica ventana de intervención para maximizar los beneficios de la cirugía. En contraste, Howie et al…”

“…En el subgrupo sintomático la tasa de accidente cerebrovascular a los 30 días fue significativamente mayor en el grupo de CAS que en el grupo de CEA (7,5% versus 2,5%, P = 0,04), lo que indica una efectividad de CEA del 97.5% en la reducción de eventos cerebrovasculares en pacientes con EACI (50). Chen et al, 2021 (51) Revisión sistemática Reino Unido 10 articulos La incidencia de accidente cerebrovascular posoperatorio en pacientes sometidos a CEA retrasada (≥48 h) fue significativamente mayor que en pacientes con CEA retrasada (<48 h) (IC 95%: 1,43-3,21, p=0.0002); por tanto, la CEA temprana es segura y eficaz en pacientes con estenosis carotídea con una efectividad de 98,57% vs 96,79 (51).…”

Retracted: Safety and Efficacy of Early Carotid Endarterectomy in Patients with Symptomatic Carotid Artery Stenosis: A Meta-Analysis

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [ 1 ]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process: Discrepancies in scope Discrepancies in the description of the research reported Discrepancies between the availability of data and the research described Inappropriate citations Incoherent, meaningless and/or irrelevant content included in the article Manipulated or compromised peer review …”

“…This article has been retracted by Hindawi following an investigation undertaken by the publisher [1]. This investigation has uncovered evidence of one or more of the following indicators of systematic manipulation of the publication process:…”