2021
DOI: 10.3389/fcvm.2021.645378
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RETRACTED: Silencing CircHIPK3 Sponges miR-93-5p to Inhibit the Activation of Rac1/PI3K/AKT Pathway and Improves Myocardial Infarction-Induced Cardiac Dysfunction

Abstract: The ceRNA network involving circular RNAs (circRNAs) is essential in the cardiovascular system. We investigated the underlying ceRNA network involving circHIPK3 in myocardial infarction (MI). After an MI model was established, cardiac function was verified, and myocardial tissue damage in mice with MI was evaluated. A hypoxia model of cardiomyocytes was used to simulate MI in vivo, and the expression of and targeting relationships among circHIPK3, miR-93-5p, and Rac1 were verified. The apoptosis of cardiomyocy… Show more

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Cited by 17 publications
(17 citation statements)
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“…circRNAs act as the molecular sponge of miRNA to relieve the repression of mRNA expression. For example, circHIPK3 sponges miR-93-5p to promote Rac expression, which aggravates infarction-induced cardiac dysfunction [ 21 ]. Another study found that HG-induced circHIPK3 sponges miR-29b to abolish the inhibition of AKT3 expression by miR-29b, which protects cardiomyocytes against ischemia/reperfusion injury [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…circRNAs act as the molecular sponge of miRNA to relieve the repression of mRNA expression. For example, circHIPK3 sponges miR-93-5p to promote Rac expression, which aggravates infarction-induced cardiac dysfunction [ 21 ]. Another study found that HG-induced circHIPK3 sponges miR-29b to abolish the inhibition of AKT3 expression by miR-29b, which protects cardiomyocytes against ischemia/reperfusion injury [ 22 ].…”
Section: Discussionmentioning
confidence: 99%
“…What is more, circRNAs can regulate parent gene expression or function as miRNA sponges to affect disease initiation and progression. For example, the silence of circHIPK3 could ameliorate MI-induced cardiac dysfunction via targeting miR-93–5p and inhibiting the Rac1/PI3K/Akt pathway ( Wu et al, 2021 ). Recently, more studies demonstrated that circRNAs can function mainly as miRNA sponges ( Misir et al, 2020 ).…”
Section: Discussionmentioning
confidence: 99%
“…CircHIPK3 is generated from the second intron of the HIPK3 gene ( Zhang et al, 2021a ). Wu et al investigated circHIPK3 function in MI-induced cardiac dysfunction Wu et al (2021) . CircHIPK3 levels were increased in animals and the MI cell model.…”
Section: Circrnas and MImentioning
confidence: 99%