RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

Favero, Gaia; Franco, Caterina; Stacchiotti, Alessandra; Rodella, Luigi Fabrizio

doi:10.3389/fphys.2020.00103

Cited by 30 publications

(31 citation statements)

References 70 publications

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“…The reduction of oxidized low-density lipoproteins and triglycerides was also linked to melatonin administration [ 160 ]. As previously mentioned, melatonin demonstrates both an anti-inflammatory and antioxidative effect in obesity [ 161 , 162 ]. Part of these properties are attributed to activation of the silent information regulator 1 (SIRT1) [ 162 ].…”

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

“…As previously mentioned, melatonin demonstrates both an anti-inflammatory and antioxidative effect in obesity [ 161 , 162 ]. Part of these properties are attributed to activation of the silent information regulator 1 (SIRT1) [ 162 ]. Furthermore, obese women with low melatonin levels have a higher risk of myocardial infarction [ 163 ].…”

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

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Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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There is a growing consensus that the antioxidant and anti-inflammatory properties of melatonin are of great importance in preserving the body functions and homeostasis, with great impact in the peripartum period and adult life. Melatonin promotes adaptation through allostasis and stands out as an endogenous, dietary, and therapeutic molecule with important health benefits. The anti-inflammatory and antioxidant effects of melatonin are intertwined and are exerted throughout pregnancy and later during development and aging. Melatonin supplementation during pregnancy can reduce ischemia-induced oxidative damage in the fetal brain, increase offspring survival in inflammatory states, and reduce blood pressure in the adult offspring. In adulthood, disturbances in melatonin production negatively impact the progression of cardiovascular risk factors and promote cardiovascular and neurodegenerative diseases. The most studied cardiovascular effects of melatonin are linked to hypertension and myocardial ischemia/reperfusion injury, while the most promising ones are linked to regaining control of metabolic syndrome components. In addition, there might be an emerging role for melatonin as an adjuvant in treating coronavirus disease 2019 (COVID 19). The present review summarizes and comments on important data regarding the roles exerted by melatonin in homeostasis and oxidative stress and inflammation related pathologies.

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Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Section: Melatonin’s Role In Programming Adult Cardiovascular Homementioning

confidence: 99%

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

et al. 2020

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“…Numerous reports indicate melatonin’s stimulatory effect on SIRT1 expression in different types of non-tumor cells ( Shah et al, 2017 ; Chen et al, 2019 ; Savran et al, 2019 ; Xu et al, 2019 ) and tissues, including heart ( Favero et al, 2020 ) and kidneys ( Bai et al, 2016 ; Shi et al, 2019 ). However, all these studies were conducted in normoxia and it seems likely that melatonin action on sirtuin 1 level may depend on oxygenation conditions.…”

Section: Discussionmentioning

confidence: 99%

Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

et al. 2021

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Although melatonin is widely known for its nephroprotective properties, there are no reports clearly pointing at its impact on the activity of hypoxia-inducible factor-1 (HIF-1), the main mediator of metabolic responses to hypoxia, in kidneys. The aim of the present study was to elucidate how melatonin affects the expression of the regulatory subunit HIF-1α in renal proximal tubules. HK-2 cells, immortalized human proximal tubular cells, were cultured under hypoxic conditions (1% O2). Melatonin was applied at 100 μM concentration. Protein and mRNA contents were determined by Western blot and RT-qPCR, respectively. HIF-1α acetylation level was established by means of immunoprecipitation followed by Western blot. Melatonin receptors MT1 and MT2 localization in HK-2 cells was visualized using immunofluorescence confocal analysis. It was found that melatonin in HK-2 cells (1) lowered HIF-1α protein, but not mRNA, content; (2) attenuated expression of HIF-1 target genes; (3) increased HIF-1α acetylation level; and (4) diminished sirtuin 1 expression (both protein and mRNA). Sirtuin 1 involvement in the regulation of HIF-1α level was confirmed applying cells with silenced Sirt1 gene. Moreover, the presence of membrane MT1 and MT2 receptors was identified in HK-2 cells and their ligand, ramelteon, turned out to mimic melatonin action on both HIF-1α and sirtuin 1 levels. Thus, it is concluded that the mechanism of melatonin-evoked decline in HIF-1α content in renal proximal tubular cells involves increased acetylation of this subunit which results from the attenuated expression of sirtuin 1, an enzyme reported to deacetylate HIF-1α. This observation provides a new insight to the understanding of melatonin action in kidneys.

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“…In a clinical trial performed with obese women, the intake of a daily dose of 6 mg MEL for 40 days significantly decreased levels of pro-inflammatory cytokines TNF-α, IL-6, and c-reactive protein [ 147 ], compared to placebo. It seems that MEL affects different signaling pathways involved in the inflammation process, such as the activation of SIRT1, a secondary signal molecule that mediates anti-inflammatory actions [ 148 , 149 ].…”

Section: Melatonin and Cardiovascular Healthmentioning

confidence: 99%

Melatonin in Wine and Beer: Beneficial Effects

et al. 2021

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Melatonin is a hormone secreted in the pineal gland with several functions, especially regulation of circadian sleep cycle and the biological processes related to it. This review evaluates the bioavailability of melatonin and resulting metabolites, the presence of melatonin in wine and beer and factors that influence it, and finally the different benefits related to treatment with melatonin. When administered orally, melatonin is mainly absorbed in the rectum and the ileum; it has a half-life of about 0.45–1 h and is extensively inactivated in the liver by phase 2 enzymes. Melatonin (MEL) concentration varies from picograms to ng/mL in fermented beverages such as wine and beer, depending on the fermentation process. These low quantities, within a dietary intake, are enough to reach significant plasma concentrations of melatonin, and are thus able to exert beneficial effects. Melatonin has demonstrated antioxidant, anticarcinogenic, immunomodulatory and neuroprotective actions. These benefits are related to its free radical scavenging properties as well and the direct interaction with melatonin receptors, which are involved in complex intracellular signaling pathways, including inhibition of angiogenesis and cell proliferation, among others. In the present review, the current evidence on the effects of melatonin on different pathophysiological conditions is also discussed.

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RETRACTED: Sirtuin1 Role in the Melatonin Protective Effects Against Obesity-Related Heart Injury

Cited by 30 publications

References 70 publications

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin’s Impact on Antioxidative and Anti-Inflammatory Reprogramming in Homeostasis and Disease

Melatonin Lowers HIF-1α Content in Human Proximal Tubular Cells (HK-2) Due to Preventing Its Deacetylation by Sirtuin 1

Melatonin in Wine and Beer: Beneficial Effects

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