Retracted: sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease

Singhal, Rajnish K; Rai, Balwant

doi:10.3889/oamjms.2017.010

Cited by 7 publications

(7 citation statements)

References 18 publications

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“…Another possible systemic alteration linked to AP is cardiovascular disease, which has been intriguing many researches since few studies have addressed the association between them. These studies assessed the alterations represented by coronary artery disease, 44,45,46 acute coronary syndrome, 4 and hypertension. 47,48 There are some studies in the literature that associated the presence of AP with cardiovascular diseases.…”

Section: B Cardiovascular Diseases and Endodontic Infectionmentioning

confidence: 99%

“…In addition, another study demonstrated that elevated levels of the receptors sTNF-R1 and sTNF-R2, which are markers for the activity of the proinflammatory cytokine TNF-α, 55 were found in periodontal disease patients, indicating an increased independent risk of CHD in these patients. 44 Regarding the possible influence of cardiovascular diseases on AP progression, one study found that hypertension did not influence the expression of proinflammatory mediators or the periapical lesion size in mice. However, the hypertension group showed elevated osteoclast differentiation in vitro.…”

Section: As Well Asmentioning

confidence: 99%

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Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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Endodontic medicine, which addresses the bidirectional relationship between endodontic infections and systemic diseases, has gained prominence in the field of endodontics. There is much evidence showing that while systemic disease may influence the pathogenesis of endodontic infection, endodontic infection can also cause systemic alterations. These alterations include more severe bone resorption and inflammation in the periapical area as well as enhanced systemic disease symptoms. Similarly, many reports have described the impact of systemic diseases on the tissue responses to dental materials. Conversely, the local use of dental materials may show systemic effects in the form of altered production of biomarkers. Thus, studies to better understand the mechanisms related to those connections are extremely important. In this context, the objective of this review was to analyze and discuss the current literature regarding the connections among these three factors-systemic diseases, endodontic infection, and endodontic dental materials-and determine how these connections may interfere in the systemic health status and the endodontic treatment outcomes, which are represented by periapical wound healing.

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Section: B Cardiovascular Diseases and Endodontic Infectionmentioning

confidence: 99%

Section: As Well Asmentioning

confidence: 99%

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

et al. 2018

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“…Compromised immune systems may play an important role in the development, progression and healing of AP (5). When dental and medical scientific communities have analyzed the relation between AP and systemic health (6), the results suggest an association between PA and diabetes mellitus (7), coronary heart disease (8), tobacco smoking (9) and other diseases like respiratory diseases (10) or osteoporosis in post menopause women (11). Multiple myeloma (MM) accounts for 10% of neoplasms in bone marrow, the average age of individuals at the time of diagnosis being 65 years, with less than 15% of cases occurring below 50 years.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Apical Periodontitis in patients with Multiple Myeloma

Sánchez¹,

Pérez-Díaz²,

Fj³

et al. 2020

Med Oral

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Background: Previous reports have been analyzed the prevalence/association of apical periodontitis (AP) with systemic diseases. The present study aims to analyze the prevalence of healthy/diseased periapex and endodontic treatments in patients with Multiple Myeloma (MM) and compare the results with those of control subjects. Material and Methods: Panoramic radiographs of 50 individuals with MM were evaluated and compared with 50 controls that were sex and age matched exactly with the diseased group. Radiographic analysis was performed by two experienced endodontists under standardized conditions. The periapical status (presence or not of AP) was assessed using the periapical index (PAI). Data included systemic health, technical quality of root fillings, total number of teeth, quality of restoration, and periapical status. Statistical evaluation of differences between groups used chi-squared tests and Fisher's exact tests. Results: The prevalence of root canal-treated teeth was 10.11% in the MM group and 12.05% in the control group (p=0.90). The average root canal-treated teeth in the test group was 2,34 and 2.48 in the control group, where the difference was statistically significant (p=0.05). AP in 1 or more teeth was found in 86 % and in 78% of the patients in the MM and the control groups, respectively. When analyzed by subject, there was no statistically significant difference in the prevalence of AP (p>0.72). Similarly there was also no statistically significant difference in the prevalence of PA (p=0.85), when analyzed by tooth, AP was found in 63.2% and 62.9% in MM and control groups. Conclusions: The presence of AP and endodontic treatment was not significantly different in individuals with MM compared with control subjects. Future studies are needed to elucidate and confirm the association between MM and AP.

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“…Apical periodontitis may occur as a tissue response to pulpal infection following from dental caries, trauma, attrition from mastication, and abrasion from the use of teeth as tools . There is growing evidence that inflammatory diseases and infections may be the cause of and related to the emergence of cardiovascular problems . As an oral disease, AP is known to be a potential risk factor for cardiovascular diseases .…”

mentioning

confidence: 99%

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

Şehirli¹,

Aksoy²,

Basmacı³

et al. 2019

European J Oral Sciences

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This study was designed to assess the possible protective effect of alpha‐lipoic acid (ALA) on apical periodontitis (AP)‐induced cardiac injury. Wistar albino rats were randomized into four groups: control; ALA; AP; and ALA + AP. Rats of the control and ALA groups were not endodontically treated, but saline and ALA (100 mg kg−1) were administered. In rats of the AP and ALA + AP groups, the pulp chambers of mandibular first molar teeth were exposed and left open for 30 d to induce AP. Saline and ALA (100 mg kg−1) were administered intraperitoneally every 24 h during the experiment. At the end of the experiment, the rats were killed. Establishment of AP was verified by radiographic and histopathological evaluation. Serum alkaline phosphatase (ALP), lactate dehydrogenase (LDH), creatine kinase (CK), and superoxide dismutase (SOD) activities were determined using an automated biochemical analyzer, and the structural cardiac injury was assessed pathologically. Serum ALP, LDH, and CK activities were elevated, and SOD activities were decreased, in the AP group. The changed enzyme activities were significantly normalized by treatment with ALA. We conclude that ALA administration alleviated the AP‐induced heart injury and improved cardiac structure and function, and therefore this agent may be of potential therapeutic value in protecting cardiac tissue from systemic injury caused by AP.

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Retracted: sTNF-R Levels: Apical Periodontitis Linked to Coronary Heart Disease

Cited by 7 publications

References 18 publications

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Endodontic medicine: interrelationships among apical periodontitis, systemic disorders, and tissue responses of dental materials

Prevalence of Apical Periodontitis in patients with Multiple Myeloma

Protective effect of alpha‐lipoic acid against apical periodontitis‐induced cardiac injury in rats

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