RETRACTED: Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma

Takai, Noriyuki; Miyazaki, Tami; Nishida, Masakazu; Nasu, Kaei; Miyakawa, Isao

doi:10.1016/s0304-3835(02)00190-8

Cited by 92 publications

(53 citation statements)

References 27 publications

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“…However, these findings were not supported by other studies showing no prognostic significance for this tumor type (Erkanli et al 2007;Ferrandina et al 2005;Fowler et al 2005). Finally, survivin, a member of the apoptosis inhibitor protein family (IAP), is a defining diagnostic marker for endometrial carcinomas that may also yield prognostic information (Takai et al 2002). The prognostic value of the co-expression pattern of c-erbB2, COX-2, and survivin in endometrial cancer tissues was examined by correlation to other clinicopathological parameters and the survival rate of endometrial cancer patients.…”

Section: Introductionmentioning

confidence: 74%

“…Studying 31 endometrial cancer cases, Takai et al (2002) reported that survivin expression was significantly associated with proliferating cell nuclear antigen-labeling index, surgical stage, histological grade, the presence of invasion to [1/2 myometrium, surgical outcome, and survival rate. In addition, survivin mRNA levels were increased in correlation with ascending grade of endometrial adenocarcinoma (Lehner et al 2002).…”

Section: Discussionmentioning

confidence: 99%

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Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients

Lambropoulou

Παπαδόπουλος

Tripsianis

et al. 2009

J Cancer Res Clin Oncol

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Section: Introductionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients

Lambropoulou

Παπαδόπουλος

Tripsianis

et al. 2009

J Cancer Res Clin Oncol

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“…Some experts have indicated an EH model with estrogen and their results showed that estrogen induces endometrial proliferation of mouse uterine epithelial cells [15]. According to primary research and the pathogenesis theory of EH [16,17], we induced the EH model in rats with a method combining ovariectomy with estrogen. After the rats were ovariectomized, endogenous estrogen and progesterone were inhibited totally.…”

Section: Discussionmentioning

confidence: 99%

Apoptotic Signaling Pathways in Uteri of Rats with Endometrial Hyperplasia Induced by Ovariectomy Combined with Estrogen

He¹,

Zhang²,

Zhang³

2013

Gynecol Obstet Invest

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Aims: To explore a new reliable method inducing an animal model similar to the morphology and apoptotic signaling pathways in endometrial hyperplasia patients. Methods: After the rats were ovariectomized, estradiol benzoate (60 µg/100 g) was intramuscularly injected on alternate days for 4 weeks. The morphology in the uterus was observed under a light microscope and by electron microscopy. The expression levels of survivin/caspase-3 and Fas/FasL were checked by immunohistochemistry, Western blotting and real-time polymerase chain reaction. Results: After the models were induced, the edema and hypertrophy in uteri were observed 4 weeks later. The glands in the endometrium had increased, indented hyperplasia of glandular cells appeared, and a pseudo-stratified phenomenon occurred. Under a transmission electron microscope, free ribosomes had markedly increased and the nucleus was enlarged in the cytoplasm. Compared with the control group, the expression of survivin increased (p < 0.05) while that of caspase-3 and Fas/FasL declined (p < 0.05). Conclusions: In the rat model of endometrial hyperplasia induced by ovariectomy with pharmacological estrogen add-back treatment, survivin, caspase-3 and Fas/FasL signaling pathways play an important role in regulating the apoptosis of glandular cells in uteri.

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“…It is different significance that survivin protein is located at nuclear and cytoplasm. Although, some people reported that the expression of survivin in the nucleus was predictive of a favorable prognosis [11] , majority was still reported that nuclear expression of survivin was associated with aggressive behavior and poor prognosis [10,12,13] . Our test supported the latter.…”

Section: Discussionmentioning

confidence: 99%

“…Although there was no statistical significance by rank sum test, the change tendency was obvious in them. Many people reported that high expression of survivin was associated with aggression of clinical procedure and poor prognosis [11,12] . Therefore, it was thought that there was poor prognosis in older patients of DLBL.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Survivin Expression in the Subtypes of Lymphoma

Gu¹,

Lin

2005

Chinese-German J Clin Oncol

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Objective: To detect the expression of survivin in subtypes of lymphoma and its value in classifying subtypes of lymphoma. Methods: Paraffin-embedded samples collected from 219 cases of lymphoma and 13 cases of lymph node reactive proliferation from affiliated hospitals of Sun Yat-sen University during 2001-2003 were examined for the expression of survivin by using immunohistochemical staining. Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the mRNA expression of survivin in K562, HL60, Raji, and Jurkat cell lines. Semi-quantitative assay was used to evaluate the quantity of survivin protein and mRNA expression in subtypes of lymphoma. Results: Protein expression of survivin was high and strong in diffuse large B-cell lymphoma (DLBL) (88.6%, 70/79), Burkitt lymphoma (BL) (100%, 2/2), and lymphoblastic lymphoma (LBL) (92.3%, 12/13), while their expression was always lower and weaker in follicular lymphoma (FL) (18.2%), extranodal marginal zone B-cell lymphoma of mucosaassociated lymphoid tissue (MALT lymphoma) (40.9%) and marginal zone lymphoma (MZL) (33.3%). There was a significant difference between the higher expression group (DLBL, BL and LBL) and lower one (FL, MZL, and MALT) in the expression of survivin (Chi-square test, χ 2 =24.77, P <0.01). Almost all of Reed-Sternberg cells (R-S cells) in Hodgkin lymphoma (HL) strongly expressed survivin. The protein expression of survivin was positively correlated with mRNA (r=0.6270, P <0.01). Conclusion: The expression level of survivin mRNA and protein shows significant difference in subtypes of lymphoma. The expression of survivin mRNA might act as a biomarker to classify the subtypes of lymphoma.It is difficult to diagnose and classify lymphoma in clinical pathology. To find a specific biomarker is an important way to overcome this problem. Survivin is a recently found member of the inhibitor of apoptosis protein (IAP) family. The distribution of survivin is different from Bcl-2. Survivin is undetectable in most normal adult tissues, but abundantly expressed in most human cancers [1] such as breast carcinoma, colon carcinoma, glioma and lung carcinoma [2−4] . In this study, immunohistochemistry and reverse transcription-polymerase chain reaction were used to detect the expression of survivin in subtypes of lymphoma and its significance. Materials and methods Cell cultureThe cell lines of K562, HL60 (myeloid leukemia), Raji, Jurkat (lymphoma) and MCF-7 (breast cancer) were provided by our department. The cells of 1×10 7 were used

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RETRACTED: Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma

Cited by 92 publications

References 27 publications

Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients

Co-expression of survivin, c-erbB2, and cyclooxygenase-2 (COX-2): prognostic value and survival of endometrial cancer patients

Apoptotic Signaling Pathways in Uteri of Rats with Endometrial Hyperplasia Induced by Ovariectomy Combined with Estrogen

Analysis of Survivin Expression in the Subtypes of Lymphoma

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