Retracted: Synthesis and surface modification of mesoporous metal-organic framework (UiO-66) for efficient pH-responsive drug delivery and lung cancer treatment

Abstract

This paper applied mesoporous metal-organic frameworks (MOFs) of UiO-66 particles for pH-responsive doxorubicin (DOX) delivery and cancer treatment. Mesoporous structured UiO-66 MOFs were synthesized, and carboxymethylcellulose (CMC) was loaded for sensitive pH response and also as a linker to encapsulate the chemotherapeutic drug of DOX. The composite of UiO-66/CMC@DOX was synthesized, and the loading capacity was as high as 45 μg DOX per mg of the carrier. The structure and crystalization of the UiO-66 MOFs were determined by the Transmitting Electron Microscope (TEM) and x-ray diffraction methods, while the loading of CMC and DOX was inspected by Fourier Transform InfraRed (FT-IR) and UV–vis spectroscopy. The DOX release from UiO-66/CMC@DOX was tested under different pH at 37 °C. The DOX accumulative release could reach 78% under the pH of 5. A lower pH was more favorable for DOX release due to the CMC shrinking and higher DOX solubility in an acidic environment. The cytotoxicity study indicated that, under the DOX concentration of 4 μg ml−1, the A549 cell (Lung Carcinoma Cell Line) viability of UiO-66/CMC was 28%, which was lower than that from free DOX solution (47%). UiO-66 MOFs were demonstrated to be an efficient drug delivery carrier for chemotherapeutic drug and release.

Design of a Zr-based metal–organic framework as an efficient fosfomycin carrier: a combined experimental and DFT study

“…43 The pH-sensitive character of UiO-66 has been fortified by adding pH sensing molecules like carboxymethyl cellulose as linkers for the effective delivery of chemotherapeutic agents at lower pH values of ∼5.5. 12 Meanwhile, Nasrabandi et al suggested pH 7.4 to be more suitable for ciprofloxacin delivery from UiO-66 and obtained favorable results in the antibacterial activity studies by disc diffusion tests. 9 Here, the bactericidal activity showed similar patterns in both pH 5.5 and pH 7.4 growth media suggesting that the UiO-66/FOS-2 nanocrystals are effective against bacteria in the pH range of 5.5–7.4.…”

“…8,9 Various types of drugs, including antibiotics, anti-inflammatory drugs, corticosteroids and chemotherapeutic drugs were loaded on the UiO-66 MOF structure by a postsynthesis route in which adsorption/impregnation takes place by suspending UiO-66 in drug solutions. [9][10][11][12][13][14] In addition to the purely experimental studies, several combined experimental and DFT studies have recently been reported regarding revealing the interaction mechanisms between UiO-66 and various drug molecules, such as carbamazepine, ciprofloxacin, and mefenamic acid, 15 metronidazole, 16 ibuprofen and naproxen, 17 and ketoprofen. 18 Fosfomycin (C 3 H 7 O 4 P) is a re-emerging natural bactericidal antibiotic for the treatment of serious infections caused by several Gram-positive and Gram-negative bacteria, including vancomycinresistant enterococci, methicillin-resistant Staphylococcus aureus, and carbapenem-resistant Enterobacteriaceae.…”

“…8,9 Various types of drugs, including antibiotics, anti-inflammatory drugs, corticosteroids and chemotherapeutic drugs were loaded on the UiO-66 MOF structure by a post-synthesis route in which adsorption/impregnation takes place by suspending UiO-66 in drug solutions. 9–14 In addition to the purely experimental studies, several combined experimental and DFT studies have recently been reported regarding revealing the interaction mechanisms between UiO-66 and various drug molecules, such as carbamazepine, ciprofloxacin, and mefenamic acid, 15 metronidazole, 16 ibuprofen and naproxen, 17 and ketoprofen. 18…”

Application of metal-organic frameworks-based drug delivery for different diseases treatment

“…Carboxymethylcellulose (CMC) was loaded into the synthesised mesoporous structured UiO-66 MOFs for sensitive pH response as well as to serve as a connector to encompass the DOX chemotherapy drug [9]. The loading capacity for the prepared MOFs-based functional materials was used to evaluate the experimental effect.…”

Doxorubicin-Loaded Core–Shell UiO-66@SiO2 Metal–Organic Frameworks for Targeted Cellular Uptake and Cancer Treatment

“…None of the UiO MOFs exhibited substantial cytotoxicity at either incubation time, except for UiO-66-NH 2 ; at a 200 µM dose and 24 h of incubation, this material showed moderate cytotoxicity to HepG2 cells. The good biocompatibility of UiO MOFs has been stated in [ 19 , 20 , 21 ].…”