RETRACTED: Temporal features of gamma activity in STN mediated by dopamine receptors in dyskinetic rat

Abstract

Background Levodopa-induced dyskinesia (LID) is a challenging complication in the advanced stages of Parkinson's disease (PD). Excessive beta and gamma oscillations of PD and LID have been frequently reported in recent cross-sectional studies. Objective We investigate the temporal features of beta and gamma activity during the development of PD and LID, as well as the regulatory role of dopamine I receptors (D1R) and dopamine III receptor (D3R). Methods We collected motor behavior and electrophysiological data during the development of PD and LID, after interventions with D1R and D3R antagonists and agonists. Results We demonstrated exaggerated beta-band activity in PD state and excessive gamma-band activity during on-state dyskinesia. Subsequently, process-dependent increased beta activity correlated with bradykinesia during PD modeling, while a process-dependent increased gamma activity correlated with dyskinesia under the cumulative effects of L-dopa during on-state dyskinesia. Finally, both D1R and D3R were found to be involved in regulating dyskinesia and gamma activity. Conclusion Dynamic oscillations is closely associated with motor behavior, and mapping dynamic oscillations should be related to optimizing DBS parameters and developing personalized neurotherapeutic targeting.