In order to improve the accuracy of trajectory tracking of in-wheel motor electric vehicles, a preview time adaptive trajectory tracking method based on iterative algorithm and fuzzy control is proposed. Firstly, based on the vehicle’s three-degree-of-freedom model, the vehicle is controlled to track trajectory based on model predictive control (MPC). The preview step size and sampling period of MPC are adjusted by iterative function and fuzzy controller, respectively. Then, In order to optimize MPC active steering control, a differential torque controller is established to realize the trajectory tracking control of differential torque steering. Finally, Carsim/Simulink co-simulation analysis and real vehicle verification are done. The simulation results show that the controller can complete the trajectory tracking control of the in-wheel motor intelligent vehicle, and the stability and steering performance are good. The controller has good robustness and adaptability according to road adhesion conditions and vehicle speed changes. At the same time, the trajectory tracking accuracy of the MPC controller is better than sliding mode variable structure control (SMC). The real vehicle verification results show that when the real vehicle tracking under different speeds, the adaptive preview time controller designed in this paper has good trajectory tracking performance and stability.