RETRACTED: The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia

Pandey, Anand Kumar; Hazari, Puja Panwar; Patnaik, Ranjana; Mishra, Anil K.

doi:10.1016/j.brainres.2011.01.085

Cited by 42 publications

(41 citation statements)

References 46 publications

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“…Studies have investigated Quercetin as an antioxidant3949, anti-angiogenic5051, neuroprotective5253, and anti-apoptotic agent5455. In ocular studies, Quercetin has been found to be efficacious in cataract prevention56, retinal angiogenesis57, and oxidative damage in retinal pigment epithelium cells5859.…”

Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

McKay

Lyon

Sarker-Nag

et al. 2015

Sci Rep

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Keratoconus(KC) is an ecstatic corneal disease leading to corneal-thinning and the formation of a cone-like cornea. Elevated lactate levels, increased oxidative stress, and myofibroblast formation have all been previously reported. In the current study, we assess the role of Quercetin on collagen secretion and myofibroblast formation in KC in vitro. Human corneal fibroblasts(HCFs) and human keratoconus cells(HKCs) were treated with a stable Vitamin C derivative and cultured for 4 weeks, stimulating formation of a self-assembled extracellular matrix. All samples were analyzed using Western blots and targeted tandem mass spectrometry. Our data showed that Quercetin significantly down regulates myofibroblast differentiation and fibrotic markers, such as α-smooth muscle actin (α-SMA) and Collagen III (Col III), in both HCFs and HKCs. Collagen III secretion was reduced 80% in both HCFs and HKCs following Quercetin treatment. Furthermore, Quercetin reduced lactate production by HKCs to normal HCF levels. Quercetin down regulated TGF-βR2 and TGF-β2 expression in HKCs suggesting a significant link to the TGF-β pathway. These results assert that Quercetin is a key regulator of fibrotic markers and ECM assembly by modulating cellular metabolism and TGF-β signaling. Our study suggests that Quercetin is a potential therapeutic for treatment of corneal dystrophies, such as KC.

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Section: Discussionmentioning

confidence: 99%

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

McKay

Lyon

Sarker-Nag

et al. 2015

Sci Rep

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“…The neuroprotective effects of quercetin on the central nervous system have been previously reported, and most of these studies were based on focal cerebral ischemia models (11,23,24). The advantage of the focal ischemia model is that the injury can be evaluated, which cannot be performed in the global brain ischemia model.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Chao

Zhang

et al. 2015

Molecular Medicine Reports

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Abstract. The present study provided experimental evidence for the neuroprotective effects of quercetin using a rat model of global brain ischemic/reperfusion (I/R) injury. Pre-treatment with quercetin (5 or 10 mg/kg orally (p.o.); once daily) induced a dose-dependent reduction in I/R-induced hippocampal neuron cell loss, with 10 mg/kg/day being the lowest dose that achieved maximal neuroprotection. Administration of 10 mg/kg quercetin over at least 3 days prior to I/R was required to improve the survival rate of I/R rats. Fluorescence-assisted cell sorting, hematoxylin and eosin staining and terminal deoxynucleotidyl transferase dUTP nick end labeling indicated neuronal cell loss in the CA1 hippocampus. Rats that had undergone transient global cerebral ischemia for 15 min followed by 1 h of reperfusion exhibited a significant increase in reactive oxygen species (ROS) production in the hippocampus. The I/R-induced ROS overproduction in the hippocampus at 1, 12 and 24 h following I/R was significantly decreased by quercetin pre-treatment. Western blot analysis revealed that the neuroprotective effects of quercetin (5 and 10 mg/kg/day, p.o.) were associated with an upregulation of the I/R-induced suppression of B-cell lymphoma-2 (Bcl-2), Bcl extra large and survivin expression as well as phosphorylation of Bcl-2-associated death promoter. Furthermore, the neuroprotective effects of quercetin (5, 10 mg/kg/day) in the brain were associated with an upregulation of Akt signaling. These findings suggested that the inhibition of I/R-induced brain injury by quercetin likely involves a transcriptional mechanism to enhance anti-apoptotic signaling.

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“…57 Indeed, treatment with quercetin reduced the spectrin breakdown products caused by ischemic activation of calcium-dependent protease cabin and inhibited the acid-mediated intracellular calcium level. 58 Some of the anthocyanins have the ability to cross the Blood-Brain Barrier (BBB) and diffuse through the central nervous system. 59 Anthocyanins have significant neuroprotective benefits in improving cognitive brain function and, defensive mechanism on oxidative stress and lipid peroxidation.…”

Section: Polyphenolsmentioning

confidence: 99%

Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs

Kumar¹,

Anilakumar²,

Naveen³

2015

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Many neuropsychiatric and neurodegenerative disorders, such as Alzheimer's disease, anxiety, cerebrovascular impairment, depression, seizures, Parkinson's disease, etc. are predominantly appearing in the current era due to the stress full lifestyle. Treatment of these disorders with prolonged administration of synthetic drugs will lead to severe side effects. In the recent years, scientists have focused the attention of research towards phytochemicals to cure neurological disorders. Nootropic herb refers to the medicinal role of various plants/parts for their neuroprotective properties by the active phytochemicals including alkaloids, steroids, terpenoids, saponins, phenolics, flavonoids, etc. Phytocompounds from medicinal plants play a major part in maintaining the brain's chemical balance by acting upon the function of receptors for the major inhibitory neurotransmitters. Medicinal plants viz. Valeriana officinalis, Nardostachys jatamansi, Withania somnifera, Bacopa monniera, Ginkgo biloba and Panax ginseng have been used widely in a variety of traditional systems of therapy because of their adaptogenic, psychotropic and neuroprotective properties. This review highlights the importance of phytochemicals on neuroprotective function and other related disorders, in particular their mechanism of action and therapeutic potential.

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RETRACTED: The role of ASIC1a in neuroprotection elicited by quercetin in focal cerebral ischemia

Cited by 42 publications

References 46 publications

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

Quercetin Attenuates Lactate Production and Extracellular Matrix Secretion in Keratoconus

Neuroprotective effects of quercetin in a mouse model of brain ischemic/reperfusion injury via anti-apoptotic mechanisms based on the Akt pathway

Phytochemicals Having Neuroprotective Properties from Dietary Sources and Medicinal Herbs

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