Retraction Note: Early use of high-dose vitamin C is beneficial in treatment of sepsis

Lv, Shijin; Zhang, Guohu; Xia, Jinjun; Yu, Huan; Zhao, Fang

doi:10.1007/s11845-022-03180-x

Cited by 1 publication

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“…Overall, 14 studies were at low risk of bias; eight studies were considered to be at low risk of bias for mortality had some concerns related to other outcomes (primarily due to lack of blinding); 16 had some concerns regarding risk of bias for all outcomes, including mortality, and eight were at high risk of bias. Of note, one study included in the earlier systematic review was subsequently retracted and was thus excluded 33 (Table S1).…”

Section: Resultsmentioning

confidence: 99%

Intravenous vitamin C therapy in adult patients with sepsis: A rapid practice guideline

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Alhazzani

Belley‐Côté

et al. 2023

Acta Anaesthesiol Scand

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BackgroundThis Rapid Practice Guideline provides an evidence‐based recommendation to address the question: in adults with sepsis or septic shock, should we recommend using or not using intravenous vitamin C therapy?MethodsThe panel included 21 experts from 16 countries and used a strict policy for potential financial and intellectual conflicts of interest. Methodological support was provided by the Guidelines in Intensive Care, Development, and Evaluation (GUIDE) group. Based on an updated systematic review, and the grading of recommendations, assessment, development, and evaluation approach, we evaluated the certainty of evidence and developed recommendations using the evidence‐to‐decision framework. We conducted an electronic vote, requiring >80% agreement among the panel for a recommendation to be adopted.ResultsAt longest follow‐up, 90 days, intravenous vitamin C probably does not substantially impact (relative risk 1.05, 95% confidence interval [CI] 0.94 to 1.17; absolute risk difference 1.8%, 95% CI −2.2 to 6.2; 6 trials, n = 2148, moderate certainty). Effects of vitamin C on mortality at earlier timepoints was of low or very low certainty due to risk of bias of the included studies and significant heterogeneity between study results. Few adverse events were reported with the use of vitamin C. The panel did not identify any major differences in other outcomes, including duration of mechanical ventilation, ventilator free days, hospital or intensive care unit length of stay, acute kidney injury, need for renal replacement therapy. Vitamin C may result in a slight reduction in duration of vasopressor support (MD −18.9 h, 95% CI −26.5 to −11.4; 21 trials, n = 2661, low certainty); but may not reduce sequential organ failure assessment scores (MD −0.69, 95% CI −1.55 to 0.71; 24 trials, n = 4002, low certainty). The panel judged the undesirable consequences of using IV vitamin C to probably outweigh the desirable consequences, and therefore issued a conditional recommendation against using IV vitamin C therapy in sepsis.ConclusionsThe panel suggests against use of intravenous vitamin C in adult patients with sepsis, beyond that of standard nutritional supplementation. Small and single center trials on this topic should be discouraged.

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Section: Resultsmentioning

confidence: 99%