Retraction Note: Genetic alterations of the NRP/B gene are associated with human brain tumors

Liang, Xing-Qun; Avraham, Hava; Jiang, Shuxian; Avraham, Shalom

doi:10.1038/s41388-023-02741-3

Cited by 1 publication

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“…According to the literature, other members of the KLHL family have been reported to promote cell growth, prevent apoptosis, and alter the cytoskeletal structure. [54] The functional enrichment of related genes in our study also revealed that KLHL38 may be involved in actin cytoskeleton reorganization, macromolecule complex assembly, cell shape regulation, etc. In the future, it is undeniable that more detailed studies on the function and molecular mechanism of KLHL38 will need to be conducted.…”

Section: Discussionsupporting

confidence: 61%

A Pan-cancer Analysis of Kelch Like Family Member 38 (KLHL38) Alterations in Human Cancers

Hai,

Liu,

Meng

et al. 2024

Preprint

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Background: Growing evidence suggests that the KLHL family may be involved in the occurrence and development of cancer. KLHL38, a member of the KLHL protein family, contains BTB/POZ, BACK domains, and five to six Kelch motifs. However, no pan-cancer analyses have been conducted on KLHL38. In this study, we aimed to explore the potential biological functions of KLHL38 that may provide potential tumor-related therapeutic targets. Methods: The potential roles of KLHL38 in different tumor types were explored based on The Cancer Genome Atlas (TCGA), Genotype-tissue expression (GTEx), Tumor Immune Estimation Resource (TIMER), and Gene Set Enrichment Analysis (GSEA) datasets. Several factors related to KLHL38 were analyzed, including expression differences, survival, pathological stage, DNA methylation, tumor mutation burden (TMB), tumor microenvironment (TME), stemness score, and immune cell infiltration. Results: There were significant differences in KLHL38 expression among different cancer types and between cancer tissue and normal tissue, which was closely correlated with survival prognosis. Furthermore, KLHL38 expression was found to be correlated with DNA methylation, tumor mutations, and stemness scores in major cancer types, suggesting its involvement in cancer development. To some extent, KLHL38 expression levels were significantly correlated with immune cell infiltration, immune checkpoint genes, and immune regulatory genes. These results indicated that KLHL38 can be used as a tumor prognostic indicator. Conclusion: In our study, we analyzed the role of KLHL38 role in tumor development and immunotherapy, which may provide a potential new target for tumor treatment.

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Section: Discussionsupporting

confidence: 61%