Retraction note: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation

Alimohammadi, Samad; Hobbenaghi, Rahim; Javanbakht, Javad; Kheradmand, Danial; Mortezaee, Reza; Tavakoli, Mitra; Khadivar, Farshid; Akbarī, Ḥamīd

doi:10.1186/s13000-016-0571-6

Cited by 14 publications

(14 citation statements)

References 4 publications

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“…Alimohammadi et al [146] reported the hypoglycaemic effect of hydroalcholic extract of Nigella sativa seeds (5, 10, and 20 mg/kg BW) in streptozotocin-induced diabetic rats (STZ). Nigella sativa at 5 mg/kg reduced blood glucose concentration level from (565.4 ± 30.9 mg/dl) to (323.2 ± 32.2 mg/dl), at 10 mg/kg it reduced blood glucose concentration level from (565.4 ± 30.9 mg/dl) to (513.2 ± 42.7 mg/dl), whereas at 20 mg/kg it reduced it from (565.4 ± 30.9 mg/dl) to (517.6 ± 27.3 mg/dl).…”

Section: Nigella Sativa Lmentioning

confidence: 99%

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

2020

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Diabetes is a chronic metabolic disorder which affects millions of people every year. If diabetes is not controlled, it can cause serious damage and a number of health complications. The aim of this paper was to review published ethnobotanical and ethnopharmacological evidences of Moroccan plants with antidiabetic potentials. Publications describing the medicinal plants used for the treatment of diabetes in Morocco were searched from the databases, including Google Scholar, Elsevier, Medline, Web of Science, SCOPUS and Pubmed. Other literature source was also used including books and theses available in library. About 750 literature references were studied, and only 240 research publications based on data from different Moroccan provinces published until June 2019 were included in this review. In total, 255 plants species belonging to 70 families were reported. Compositae and Lamiaceae were mentioned as the most represented families. The frequently used plant species in the dwellers of most regions of Morocco are Trigonella foenum-graecum, Artemesia herba-alba, Nigella sativa, Olea europaea, Allium cepa and Marrubium vulgare. This review provides useful information and current scientific knowledge on the medicinal plants used to manage diabetes in Morocco. Medicinal plants reported should be submitted to chemical, pharmacological and clinical studies to identify pharmacologically active metabolites and to confirm their antidiabetic activity.

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Section: Nigella Sativa Lmentioning

confidence: 99%

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

2020

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“…[ 8 ] The glucose lowering and antidiabetic effects of NS has been reported in different diabetic animal models. [ 9 , 10 ] Benhaddou-Andaloussi et al [ 11 ] have demonstrated that NS ethanol extract exhibits a remarkable ability in vitro to concomitantly increase insulin secretion, induce proliferation of pancreatic β-cells, and stimulate glucose uptake in skeletal muscle and fat cells. In another study, the same investigators reported that treatment with NS ethanol extract, in diabetic ‘ Meriones shawi ’ rats, caused a progressive normalization of glycaemia, albeit slower than that of metformin controls and exerted an insulin-sensitizing action, compared to diabetic controls.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa Improves Glycemic Control and Ameliorates Oxidative Stress in Patients with Type 2 Diabetes Mellitus: Placebo Controlled Participant Blinded Clinical Trial

et al. 2015

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Background and ObjectiveOxidative stress plays an important role in pathogenesis of diabetes mellitus and its complications. Our previous study has shown glucose lowering effect produced by 3 months supplementation of Nigella sativa (NS) in combination with oral hypoglycemic drugs among type 2 diabetics. This study explored the long term glucose lowering effect (over one year) of NS in patients with type 2 diabetes mellitus on oral hypoglycemic drugs and to study its effect on redox status of such patients.Methods114 type 2 diabetic patients on standard oral hypoglycemic drugs were assigned into 2 groups by convenience. The control group (n = 57) received activated charcoal as placebo and NS group (n = 57) received 2g NS, daily, for one year in addition to their standard medications. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), C- peptide, total antioxidant capacity (TAC), superoxide dismutase (SOD), catalase (CAT), glutathione and thiobarbituric acid reactive substances (TBARS) at the baseline, and every 3 months thereafter were determined. Insulin resistance and β-cell activity were calculated using HOMA 2 calculator.ResultsComparison between the two groups showed a significant drop in FBG (from 180±5.75 to 180±5.59 in control Vs from 195±6.57 to 172 ±5.83 in NS group), HbA1c (from 8.2±0.12 to 8.5±0.14 in control VS from 8.6±0.13 to 8.2±0.14 in NS group), and TBARS (from 48.3±6.89 to 52.9 ±5.82 in control VS from 54.1±4.64 to 41.9 ±3.16 in NS group), in addition to a significant elevation in TAC, SOD and glutathione in NS patients compared to controls. In NS group, insulin resistance was significantly lower, while β-cell activity was significantly higher than the baseline values during the whole treatment period.ConclusionLong term supplementation with Nigella sativa improves glucose homeostasis and enhances antioxidant defense system in type 2 diabetic patients treated with oral hypoglycemic drugs.Trial RegistrationClinical Trials Registry-India (CTRI) CTRI/2013/06/003781

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“…The N. sativa seed ethanol extract could also inhibit gluconeogenesis by the liver and muscle activation of adenosine monophosphate-activated protein kinase (AMPK)(Benhaddou-Andaloussi et al, 2011). It was demonstrated that TQ (the main constituent of N. sativa) could reduce the expression of gluconeogenic enzymes (glucose-6-phosphatase and fructose 1, 6 bisphosphatase) and hepatic glucose production(Al-Rasheed et al, 2014;Alimohammadi et al, 2013). TQ could increase the uptake of low-density lipoprotein-cholesterol (LDL-C) by upregulation of hepatic receptors of LDL-C(Ibrahim et al, 2014a).…”

mentioning

confidence: 98%

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review

Gholamnezhad

Havakhah

Boskabady

2016

Journal of Ethnopharmacology

235

150

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Retraction note: Protective and antidiabetic effects of extract from Nigella sativa on blood glucose concentrations against streptozotocin (STZ)-induced diabetic in rats: an experimental study with histopathological evaluation

Cited by 14 publications

References 4 publications

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

Ethnopharmacological review of medicinal plants used to manage diabetes in Morocco

Nigella sativa Improves Glycemic Control and Ameliorates Oxidative Stress in Patients with Type 2 Diabetes Mellitus: Placebo Controlled Participant Blinded Clinical Trial

Preclinical and clinical effects of Nigella sativa and its constituent, thymoquinone: A review

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