Retraction Note to: Randomized controlled trial testing weight loss and abdominal obesity outcomes of moxibustion

Hsieh, Ching-Hsiu; Tseng, Chia-Yi; Shen, Ju-Yu; Chuang, Pei-Ying

doi:10.1186/s12938-020-0749-8

Cited by 5 publications

(6 citation statements)

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“…The severity of the error, ranging from invalidating the conclusions [152] to simply requiring clarification, means that different considerations exist for each type of error. For example, some invalidating errors are consequent to the design and cannot be fixed, and retractions have been issued [29,153,154]. For other examples such as PREDIMED, for which errors in randomization required a reanalysis as a quasi-experimental design, the reanalysis, retraction, and republication serve as an important example of scientific questioning and transparency of research methods [155].…”

Section: Discussionmentioning

confidence: 99%

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Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance

et al. 2021

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Randomization is an important tool used to establish causal inferences in studies designed to further our understanding of questions related to obesity and nutrition. To take advantage of the inferences afforded by randomization, scientific standards must be upheld during the planning, execution, analysis, and reporting of such studies. We discuss ten errors in randomized experiments from real-world examples from the literature and outline best practices for their avoidance. These ten errors include: representing nonrandom allocation as random, failing to adequately conceal allocation, not accounting for changing allocation ratios, replacing subjects in nonrandom ways, failing to account for non-independence, drawing inferences by comparing statistical significance from within-group comparisons instead of between-groups, pooling data and breaking the randomized design, failing to account for missing data, failing to report sufficient information to understand study methods, and failing to frame the causal question as testing the randomized assignment per se. We hope that these examples will aid researchers, reviewers, journal editors, and other readers to endeavor to a high standard of scientific rigor in randomized experiments within obesity and nutrition research.

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Section: Discussionmentioning

confidence: 99%

“…Use of statistical principles to examine the likelihood that randomization was properly implemented has flagged other studies related to nutrition and obesity, too [25][26][27][28]. In at least four cases, publications were retracted [22,26,29,30].…”

Section: Introductionmentioning

confidence: 99%

Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance

et al. 2021

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“…Moxibustion, as a green therapy for weight loss because of its safe operation, outstanding curative effect, low cost, and good patient compliance, has become a popular treatment option for obese patients in recent years. Numerous studies indicate that moxibustion is efficient in relieving menopausal symptoms by enhancing the immune system and altering the amounts of neurotransmitters in the central nervous system through repeatedly stimulating acupoints [18,19]. As far as we know, by applying moxa to warm acupoints and body areas, moxibustion can promote a smoother flow of qi and blood in the human body [20].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Moxibustion for Menopausal Obesity: A Multicentre, Randomized, Controlled Trial Protocol

Huang

Zhang

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. In the past, moxibustion has been widely used to treat endocrine system disorders, but evidence of its effectiveness is scarce at this point. The aim of this multicenter, randomized, controlled trial is to evaluate the efficacy and safety of treating menopausal obesity with moxibustion. Methods/Design. There are six centers taking part in this randomized, controlled, parallel trial. A total of 216 patients with menopausal obesity will be randomly divided into two equal groups: the “moxibustion for harmonization of Yin and Yang” group and the gentle moxibustion group. A 12-week study period with moxibustion will be preceded by a 1-week baseline, followed by a 12-week follow-up. We will conduct an interim analysis to determine whether or not the treatment is efficacious and safe after 216 participants have completed a 12-week treatment period. Evaluations will be conducted at weeks 0, 4, 8, 12, 18, and 24. The main outcome is waist circumference (WC), and the rate of WC reduction will be compared to the baseline. An intention-to-treat analysis will be performed with a two-sided P value of <0.05 considered significant. Participants who withdraw from the trial will be analyzed according to the intention-to-treat formula (ITT). Discussion. These results will be used to support selecting the right moxibustion prescription and guiding the improvement of clinical efficacy. This trial will provide convincing evidence of moxibustion’s effectiveness and safety in the treatment of obesity by “moxibustion for harmonization of Yin and Yang,” which will be conducive to the promotion and clinical application of the theory of “moxibustion for harmonization of Yin and Yang.” Trial Registration. This trial is registered with Clinical Trials.gov: NCT04943705 (registered on June 27, 2021).

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“…A number of studies have demonstrated that moxibustion is effective in enhancing the immune system, and modifying neurotransmitter levels of central nervous system through repeated acupoint stimulation. [ 16 , 17 ] Studies have shown that moxibustion induces a smoother flow of qi and blood in the human body by using moxa to warm acupoints and body regions, accelerates the blood circulation overall, thereby achieving the effects of disease prevention and health care. [ 18 ] Moxibustion can be applied to patients indirectly (placing a medium between the skin and the burning moxa) or directly (placing burn cones directly onto the skin).…”

Section: Introductionmentioning

confidence: 99%

Moxibustion combined with characteristic lifestyle intervention of Traditional Chinese Medicine in the treatment of abdominal obesity

et al. 2020

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Background: Abdominal obesity occurs when excessive visceral and subcutaneous fat is built up around the abdomen and stomach, which negatively impacts human health. Moxibustion, arose from Traditional Chinese Medicine (TCM), has been widely applied in the treatment of abdominal obesity. Several studies have shown the positive effects of moxibustion in prevention and treatment of endocrine issues and excess body weight. In this context, our study aims to examine the safety and efficacy of the combination of moxibustion and characteristic lifestyle intervention of TCM in the treatment of abdominal obesity. Methods/design: This study will be a multicenter, randomized, controlled trial conducted from September 2020 to January 2022 that includes 150 participants who have abdominal obesity and meet the eligibility criteria. The participants will be randomly divided into 3 groups in a 2:2:1 allocation ratio. The intervention group will receive moxibustion combined with characteristic lifestyle intervention of TCM; the other group will receive moxibustion combined with lifestyle intervention; the control group will receive lifestyle intervention only. Eight-week moxibustion sessions will be provided to participants assigned to the 2 intervention groups. The characteristic lifestyle intervention of TCM will also last 8 weeks, whereas the lifestyle intervention will last 12 weeks including 8-week treatment period, 4-week follow-up period. The primary outcome is the waist circumference measured by a tape measure. The secondary outcomes include obesity-related indicators, serum biochemical indexs, blood pressure, conversion score of physical symptoms, and measurement of the scale. Adverse events will be recorded during the treatment and follow-up period. Discussion: The results are expected to provide clinical evidence for the application of the combination of moxibustion and characteristic lifestyle intervention of TCM in patients with abdominal obesity. Trial registration: ClinicalTrials.gov, NCT04501198, Registered on 9 June 2020.

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Retraction Note to: Randomized controlled trial testing weight loss and abdominal obesity outcomes of moxibustion

Cited by 5 publications

References 1 publication

Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance

Errors in the implementation, analysis, and reporting of randomization within obesity and nutrition research: a guide to their avoidance

Efficacy and Safety of Moxibustion for Menopausal Obesity: A Multicentre, Randomized, Controlled Trial Protocol

Moxibustion combined with characteristic lifestyle intervention of Traditional Chinese Medicine in the treatment of abdominal obesity

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