Retransplantation for recurrent hepatitis C: Positive aspects

McCashland, Timothy M.

doi:10.1053/jlts.2003.50249

Cited by 27 publications

(21 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…RT for this indication ranges from 3.6% to 44% [15] and has shown an increase during recent years. In Spain, 14,223 patients underwent LT between 1984 and 2008 and 4925 (34.6%) had HCV-infection.…”

Section: Improving Survival In Hcv-infected Patients After Rtmentioning

confidence: 91%

See 1 more Smart Citation

Retransplantation in patients with hepatitis C recurrence after liver transplantation

Carrión

Navasa

Forns

2010

Journal of Hepatology

View full text Add to dashboard Cite

Hepatitis C virus (HCV) infection recurs universally after liver transplantation (LT) and fibrosis progression is accelerated in the graft. Retransplantation (RT) is the only therapeutic option to achieve long-term survival in patients with decompensated cirrhosis after LT. Patient and graft survival rates after RT are inferior to those after primary LT. It is generally accepted that severe hepatitis C recurrence (cholestatic hepatitis) and forms with rapid fibrosis progression have a poor survival after RT. However, it is not clear whether rapid fibrosis progression in the first graft will be followed by the same rate of fibrosis progression in the second graft. The use of prognostic scores as screening tools has shown an improvement in survival in HCV-infected patients after RT, reaching similar survival rates as those obtained in non HCV-infected patients. Moreover, these scores can identify candidates with a high risk of mortality in whom the use of a new organ would be unreasonable. Prevention of severe hepatitis C recurrence could be the first step to avoid RT. Thus, antiviral treatment on the waiting list (if possible) and early identification and treatment of patients with severe hepatitis C recurrence may be a good strategy to avoid RT. In addition, active management of factors which can accelerate fibrosis progression (donor age, post-transplant diabetes, high dose of corticosteroids) might reduce the incidence of severe forms of hepatitis C recurrence.

show abstract

Section: Improving Survival In Hcv-infected Patients After Rtmentioning

confidence: 91%

“…Among patients with multiple RTs, a recent analysis of the Spanish Transplant Organization showed a worse outcome in individuals with more than one RT [14] ( [15]. However, Akpinar et al [16], evaluated 2527 LT between 1987 and 2008.…”

Section: Retransplantation In Hcv-infected Patients: General Considermentioning

confidence: 99%

Retransplantation in patients with hepatitis C recurrence after liver transplantation

Carrión

Navasa

Forns

2010

Journal of Hepatology

View full text Add to dashboard Cite

show abstract

“…A high prevalence is observed in transplanted HIV/HCV co-infected patients (9,10). The prognosis is very poor, with 50 to 90% mortality at two years, and re-transplantation for this specific complication is controversial with frequent pejorative outcomes (7,9,11). Several studies have shown that LT patients who achieved sustained virological response (SVR) had improved survival.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of Sofosbuvir and Daclatasvir in Patients With Fibrosing Cholestatic Hepatitis C After Liver Transplantation

Sebagh

Radenne

Botta

et al. 2015

Clinical Gastroenterology and Hepatology

125

View full text Add to dashboard Cite

show abstract

“…Second transplants remain controversial and require comprehensive discussions in view of the low availability of organs and the use of MELD score as an organ allocation criterion, which implies that second transplants will be given to recurrent patients presenting more severe clinical profiles. In general, a second transplant is recommended if one of the variables related to recurrence, and thus the natural history of HCV recurrence, can be altered [45][46][47].…”

Section: Second Transplants In Cases Of Hepatitis C Recurrencementioning

confidence: 99%